Background Accurate CNS tumor diagnosis can be challenging, and methylation profiling
can serve as an adjunct to classify diagnostically difficult cases. Methods An integrated …

We sought to identify factors that are predictive of liver transplantation or death in patients
with primary sclerosing cholangitis (PSC), and to develop and validate a contemporaneous …

We perform an immunogenomics analysis utilizing whole-transcriptome sequencing of 657
pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally …

The hypothalamus contains neurons that integrate hunger and satiety endocrine signals from
the periphery and are implicated in the pathophysiology of obesity. The limited availability …

CD19 chimeric antigen receptor T-cell therapy (CD19-CAR) has changed the treatment
landscape and outcomes for patients with pre–B-cell acute lymphoblastic leukemia (B-ALL). …

Pregnancies resulting from fresh in vitro fertilization (IVF) cycles exposed to supraphysiologic
estrogen levels have been associated with higher rates of low birth weight and small for …

Simple Summary Tumor mutation burden (TMB) has shown promise as a biomarker for immune
checkpoint blockade therapy in some cancers, but not consistently in gliomas. The goal …

Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven
primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 …

Purpose: We analyzed whole transcriptome sequencing in tumors from 23 patients with
stage III or IV melanoma from a pilot trial of the anti-GD2 immunocytokine, hu14.18-IL2, to …

Astroblastomas (ABs) are rare brain tumors of unknown origin. We performed an integrative
genetic and epigenetic analysis of AB-like tumors. Here, we show that tumors traceable to …