BACKGROUND The success of human societies depends intimately on the living components
of natural and managed systems. Although the geographical range limits of species are …

Hantaviruses are enveloped RNA viruses each carried by a specific rodent species. Three
hantaviruses, Puumala, Dobrava, and Saaremaa viruses, are known to cause haemorrhagic …

EVELOPMENTAL growth, the remodeling and regeneration of adult tissues as well as solid
tumor growth, can only occur accompanied by blood vessel formation. Angioblasts and …

Somatic mutations in cancer genomes are caused by multiple mutational processes, each
of which generates a characteristic mutational signature 1 . Here, as part of the Pan-Cancer …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

We have recently cloned the human fms-like tyrosine kinase 4 gene FLT4, whose protein
product is related to two vascular endothelial growth factor receptors FLT1 and KDR/FLK1. …

Background & Aims: Identification of the hereditary nonpolyposis colorectal cancer (HNPCC)
syndrome enables prevention of colorectal cancer (CRC) by means of colonoscopy and …

Background Myelodysplastic syndromes are a diverse and common group of chronic
hematologic cancers. The identification of new genetic lesions could facilitate new diagnostic and …

The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale …

Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in
embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGF-C stimulates the …