The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a
major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc …

Parkinson disease is characterized cytopathologically by the deposition in the midbrain of
aggregates composed primarily of the presynaptic neuronal protein α-synuclein (AS). …

In this work, we developed a water‐soluble caging group based on a π‐extended BODIPY
scaffold able to release carboxylate‐containing cargo upon red light illumination (λ irr =633 …

Introduction of the dialkylaminophenyl group in position 7 of 3-hydroxychromone changes
the orientation of the excited-state dipole moment and leads to superior solvatochromic …

Parkinson's disease is a yet incurable, age‐related neurodegenerative disorder characterized
by the aggregation of small neuronal protein α‐synuclein into amyloid fibrils. Inhibition of …

Herein, the efficient interaction of an environment-sensitive fluorophore that undergoes
excited-state intramolecular proton transfer (ESIPT) with DNA has been realized by conjugation …

Interactions of the presynaptic protein α-synuclein with membranes are involved in its
physiological action as well as in the pathological misfolding and aggregation related to …

Aggregation of neuronal protein α-synuclein leads to the formation of amyloid fibrils, which
are associated with the development of Parkinson's disease. The mechanism of α-synuclein …

The synthesis of a novel class of fluorescent nucleosides featuring 2-aryl-3-hydroxychromones
(3-HC) as base analogues is described. Nucleoside 1a bearing the 2-thienyl-3-HC …

Background Aggregation of the neuronal protein α-synuclein into amyloid fibrils is a hallmark
of Parkinson's disease. The propensity of α-synuclein to aggregate increases with the …