Cross‐presentation involves the uptake and processing of exogenous antigens within the
major histocompatibility complex (MHC) class I pathway. This process is primarily performed …

This review examines the role of cross-presentation in tolerance and immunity. We discuss (a)
the antigenic requirements for cross-presentation, (b) the phenotype of the antigen …

… on dermal fibroblasts in the skin (SN Mueller & WR Heath, unpublished observations). …
Gebhardt, FR Carbone & WR Heath, unpublished observations). These findings are consistent …

We have used organ culture of fetal thymic lobes from T cell receptor (TCR) transgenic j? &f (-I-)
mice to study the role of peptides in positive selection. The TCR used was from a CD8+ …

Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are
presented on target cells by the class I major histocompatibility complex. CTLs are responsible …

We describe the generation of ovalbumin (OVA)‐specific, MHC class II‐restricted αβ T cell
receptor (TCR) transgenic mice. Initial attempts at generating these transgenic mice utilized …

Effective immunity is dependent on long-surviving memory T cells. Various memory subsets
make distinct contributions to immune protection, especially in peripheral infection. It has …

Tissue-resident memory T cells (T RM cells) provide superior protection against infection in
extralymphoid tissues. Here we found that CD103 + CD8 + T RM cells developed in the skin …

Class I–restricted presentation is usually associated with cytoplasmic degradation of cellular
proteins and is often considered inaccessible to exogenous antigens. Nonetheless, certain …

In this report, we show that cross-presentation of self-antigens can lead to the peripheral
deletion of autoreactive CD8 + T cells. We had previously shown that transfer of ovalbumin (OVA…