Alternative splicing contributes to muscle development, but a complete set of muscle-splicing
factors and their combinatorial interactions are unknown. Previous work identified ACUAA (“…

A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to
sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli …

Amniotic fluid (AF) provides critical biological and physical support for the developing fetus.
While AF is an excellent source of progenitor cells with regenerative properties, recent …

Quaking protein isoforms arise from a single Quaking gene and bind the same RNA motif to
regulate splicing, translation, decay, and localization of a large set of RNAs. However, the …

Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B),
a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus …

Genes associated with increased susceptibility to multiple sclerosis (MS) have been identified,
but their functions are incompletely understood. One of these genes codes for the RNA …

Quaking (QkI) is a prototypical member of the STAR (signal transducer and activator of RNA)
protein family, which plays key roles in posttranscriptional gene regulation by controlling …

Quaking (QKI) controls RNA metabolism in many biological processes including innate
immunity, where its roles remain incompletely understood. To illuminate these roles, we …

Chronic, non-healing venous ulcers of the lower extremity are often limb-threatening conditions.
Their management is characterized by a prolonged and frequently frustrating clinical …

Alternative splicing is critical for development; however, its role in the specification of the
three embryonic germ layers is poorly understood. By performing RNA-Seq on human …