Rationale: Independent replication of genetic associations in complex diseases, particularly
in whole-genome association studies, is critical to confirm the association. Objectives: A …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide
variation from this region remain largely uncharacterized. We studied genomic …

Background Asthma is a complex disease with both genetic and environmental causes.
Genome-wide association studies of asthma have mostly involved European populations, and …

… Chapela, and W. Rodriguez-Cintron recruited and characterized subjects whose data
were analyzed as part of this study. S. Choudhry performed all analyses related to ancestry. …

Existing methods to ascertain small sets of markers for the identification of human population
structure require prior knowledge of individual ancestry. Based on Principal Components …

Background The primary rescue medication to treat acute asthma exacerbation is the short-acting
β 2 -adrenergic receptor agonist; however, there is variation in how well a patient …

Most individuals throughout the Americas are admixed descendants of Native American,
European, and African ancestors. Complex historical factors have resulted in varying …

Rationale: Air pollution is a known asthma trigger and has been associated with short-term
asthma symptoms, airway inflammation, decreased lung function, and reduced response to …

Background Self-identified race or ethnic group is used to determine normal reference standards
in the prediction of pulmonary function. We conducted a study to determine whether the …