Rhinoviruses and their receptors: implications for allergic disease
YA Bochkov, JE Gern - Current allergy and asthma reports, 2016 - Springer
… We then confirmed that this mutation also mediates enhanced RV-C binding and replication
in vitro and developed a HeLa cell line (HeLa-E8) stably expressing the CDHR3-Y 529 …
in vitro and developed a HeLa cell line (HeLa-E8) stably expressing the CDHR3-Y 529 …
[HTML][HTML] The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development
…, BJ Hales, ML Walker, E Hollams, YA Bochkov… - Cell host & …, 2015 - cell.com
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …
[HTML][HTML] Rhinovirus wheezing illness and genetic risk of childhood-onset asthma
M Çalışkan, YA Bochkov, E Kreiner-Møller… - … England Journal of …, 2013 - Mass Medical Soc
Background Both genetic variation at the 17q21 locus and virus-induced respiratory wheezing
illnesses are associated with the development of asthma. Our aim was to determine the …
illnesses are associated with the development of asthma. Our aim was to determine the …
[HTML][HTML] Clinical and molecular features of human rhinovirus C
YA Bochkov, JE Gern - Microbes and infection, 2012 - Elsevier
… We were able to successfully distinguish and type HRV in nasal samples co-infected with
different strains of the HRV-A, HRV-B and HRV-C in all possible combinations (Bochkov & Gern…
different strains of the HRV-A, HRV-B and HRV-C in all possible combinations (Bochkov & Gern…
Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication
YA Bochkov, K Watters, S Ashraf… - Proceedings of the …, 2015 - National Acad Sciences
… , C 529 Y) was … -Y 529 variant had about 10-fold increases in RV-C binding and progeny
yields. We developed a transduced HeLa cell line (HeLa-E8) stably expressing CDHR3-Y 529 …
yields. We developed a transduced HeLa cell line (HeLa-E8) stably expressing CDHR3-Y 529 …
[HTML][HTML] Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma
YA Bochkov, KM Hanson, S Keles… - Mucosal …, 2010 - Elsevier
Rhinovirus (RV) infections trigger asthma exacerbations. Genome-wide expression analysis
of RV1A-infected primary bronchial epithelial cells from normal and asthmatic donors was …
of RV1A-infected primary bronchial epithelial cells from normal and asthmatic donors was …
Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations
…, RF Vrtis, MD Evans, RE Gangnon, YA Bochkov… - Journal of allergy and …, 2014 - Elsevier
Background Detection of either viral or bacterial pathogens is associated with wheezing in
children; however, the influence of both bacteria and viruses on illness symptoms has not …
children; however, the influence of both bacteria and viruses on illness symptoms has not …
Effects of omalizumab on rhinovirus infections, illnesses, and exacerbations of asthma
…, AG Togias, KG Grindle, YA Bochkov… - American journal of …, 2017 - atsjournals.org
Rationale: Allergic inflammation has been linked to increased susceptibility to viral illnesses,
but it is unclear whether this association is causal. Objectives: To test whether omalizumab …
but it is unclear whether this association is causal. Objectives: To test whether omalizumab …
[HTML][HTML] Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C
YA Bochkov, AC Palmenberg, WM Lee, JA Rathe… - Nature medicine, 2011 - nature.com
A recently recognized human rhinovirus species C (HRV-C) is associated with up to half of
HRV infections in young children. Here we propagated two HRV-C isolates ex vivo in organ …
HRV infections in young children. Here we propagated two HRV-C isolates ex vivo in organ …
Translational efficiency of EMCV IRES in bicistronic vectors is dependent upon IRES sequence and gene location
YA Bochkov, AC Palmenberg - Biotechniques, 2006 - Future Science
The internal ribosomal entry site (IRES) from encephalomyocarditis virus (EMCV) is a popular
RNA element used widely in experimental and pharmaceutical applications to express …
RNA element used widely in experimental and pharmaceutical applications to express …