Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination
- Elhanati - 2018 - Immunological Reviews - … Elhanati and Sethna contributed equally. …

Although mutations in DNA are the best-studied source of neoantigens that determine
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells could …

Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more
immunogenic cancer cells to cause less immunogenic clones to dominate a population. …

We quantify the VDJ recombination and somatic hypermutation processes in human B cells
using probabilistic inference methods on high-throughput DNA sequence repertoires of …

… x is the probability of the VD insertion extending from x + 1 to y; … y x is the same for DJ
insertions; D y x corresponds to weights of the D segment extending from x + 1 to y, conditioned on …

The efficient recognition of pathogens by the adaptive immune system relies on the diversity
of receptors displayed at the surface of immune cells. T-cell receptor diversity results from …

T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-resident
T cells at sites of pathology in human organs remains poorly understood. We examined …

The diversity of T-cell receptors recognizing foreign pathogens is generated through a
highly stochastic recombination process, making the independent production of the same …

T cell discrimination of self and non-self is the foundation of the adaptive immune response,
and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate …

… For example, some of the features of the TRB designated by (CASSGRQGVATQYF,
TRBV06-05, TRBJ02-05) are ‘CDR3 length 14’, ‘S in position 3 from the left’, ‘Y in position -2 from …