Chemical modification of nucleotide bases in DNA provides one mechanism for conveying
information in addition to the genetic code. 5-methylcytosine (5mC) represents the most …

Single nucleotide polymorphism (SNP) discovery and genotyping are essential to genetic
mapping. There remains a need for a simple, inexpensive platform that allows high-density …

A variety of small RNAs, including the Dicer-dependent miRNAs and the Dicer-independent
Piwi-interacting RNAs, associate with Argonaute family proteins to regulate gene expression …

Combatting the ever-increasing threat from invasive fungal pathogens faces numerous
fundamental challenges, including constant human exposure to large reservoirs of species in the …

Trimethylated lysine 27 on histone H3 (H3K27me3) is present in Drosophila, Arabidopsis,
worms, and mammals, but is absent from yeasts that have been examined. We identified and …

… The dim-8 gene was isolated by selecting for mutants that are defective in methylation (ZA
Lewis, KK Adhvaryu, S. Honda, and EU Selker, unpubl.). Since dim-5 strains are female sterile…

High-density microarrays were used to profile circadian gene expression in Neurospora
crassa cultures grown in constant darkness. We identified 145 clock-controlled genes (ccgs). …

Polycomb group (PcG) proteins form multiple complexes that direct assembly of transcriptionally
repressed chromatin, an essential process for multicellular development. Recent …

Methylation of DNA and of Lysine 9 on histone H3 (H3K9) is associated with gene silencing
in many animals, plants, and fungi. In Neurospora crassa, methylation of H3K9 by DIM-5 …

Circadian-regulated gene expression is predominantly controlled by a transcriptional negative
feedback loop, and it is evident that chromatin modifications and chromatin remodeling …