Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties
of polyploid cells are not well understood. During evolution, polyploidy is thought to be an …

… Author links open overlay panel Neil J Ganem 1 , Zuzana Storchova 1 , David Pellman 1 2
… Z Storchova is supported by The Claudia Adams-Barr Foundation. … Storchova, D. Pellman …

… Zuzana Storchova, Christian Kuffer; The consequences of tetraploidy and aneuploidy. J
Cell Sci 1 December 2008; 121 (23): 3859–3866. doi: https://doi.org/10.1242/jcs.039537 …

… Full scan MS spectra (m/z 300–1650) were acquired in the Orbitrap analyzer after
accumulation to a target value of 10 6 in the linear ion trap (resolution of 60 000 at 400 m/z). …

Polyploidy, increased sets of chromosomes, occurs during development, cellular stress,
disease and evolution. Despite its prevalence, little is known about the physiological alterations …

Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe
developmental defects, yet the molecular mechanisms explaining its effects on cellular …

… Images were collected by taking z-stacks with a step size of 0.3 μm covering the entire
volume of the mitotic spindle. Fluorescence signal quantification in the spindle was performed …

Do young and old protein molecules have the same probability to be degraded? We addressed
this question using metabolic pulse-chase labeling and quantitative mass spectrometry …

INTRODUCTION DNA damage encountered during DNA replication represents a major
challenge to the integrity of the genome. Because replicative polymerases are unable to …

Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here,
we investigated the relationship between aneuploidy and cancer development using cells …