bioRxiv is an online archive and distribution service for preprints in the life sciences. It is operated by Cold Spring Harbor Laboratory, a not-for-profit research and educational institution.
An article may be deposited in bioRxiv in draft or final form, provided that it concerns a relevant scientific field, the content is unpublished at the time of submission, and all its authors have consented to its deposition. Authors wishing to deposit manuscripts must first register on the site. There is no charge for registration or article deposition.
bioRxiv is a source of technical information and should not be used to distribute other kinds of content such as news, product advertisements, or policy statements. All articles uploaded to bioRxiv undergo a basic screening process for offensive and/or non-scientific content and for material that might pose a health or biosecurity risk. Articles are not peer-reviewed before being posted online. No endorsement of their methods, assumptions, conclusions or scientific quality by Cold Spring Harbor Laboratory is implied by their appearance in bioRxiv.
Articles are not typeset before being posted online. The author’s manuscript is either submitted as, or automatically converted into, a PDF file.
Articles appear in bioRxiv in the order in which they were received. They are retrievable via the web interface at no charge.
The simplest way to deposit a manuscript on bioRxiv is to upload a single PDF including the text and any figures/tables. Supplemental data should be created in a separate file or files.
Alternatively, you may upload a Word file containing the main text (plus any tables) and separate figure files, from which a single PDF will be created. An automated PDF-conversion engine is responsible for the conversion and it can process many figure file formats, including JPEG, TIFF, EPS, PowerPoint. These formats are not compatible, however: PICT, Bitmap, Excel, PSD. For these files, you will need to convert them to PDF or an acceptable file format.
LaTeX files should be converted to PDF prior to submission; they may also be uploaded as Supplemental Material.
Supplementary Material and Data Use
Authors are free to include Supplemental Material such as additional tables and MPEG files. Large data sets, however, should instead be deposited in the appropriate community database (e.g., Protein Data Bank [PDB], GenBank). (See "Revisions" guidelines below.)
Authors should abide by all relevant community guidelines for use and acknowledgment of data resources (e.g., the Fort Lauderdale guidelines), obtaining permission where required and citing the appropriate laboratory, website, and accession numbers.
Terms of distribution
After an article is deposited in bioRxiv, it is citable and therefore cannot be removed. The copyright remains with the author, who is asked to select from several distribution/reuse options under which to make the article available (CC-BY, CC-BY-NC, CC-BY-ND, CC-BY-NC-ND, or no reuse). By posting on bioRxiv, authors explicitly consent to text mining of their work (e.g., by search engines or researchers).
bioRxiv reserves the right to identify and remove any articles that contain plagiarized material or describe experimental work that is not performed in accordance with the relevant ethical standards for research using animals or human subjects.
Articles in bioRxiv are categorized as New Results, Confirmatory Results, or Contradictory Results. Please select the category that best describes your findings.
- New Results is most appropriate for articles that describe an advance in a field.
- Confirmatory Results should be selected if the findings largely replicate and confirm previously published work.
- Contradictory Results should be selected if the studies largely replicate experimental approaches used in previously published work but the results contradict and/or do not support it.
Preprints deposited in bioRxiv can be cited using their digital object identifier (doi).
Example: Author AN, Author BT. 2013. My article title. bioRxiv doi: 10.1101/123456
Authors are free to submit a revised version of an article at any time (prior to publication in a journal) by clicking on ‘submit a revision’ within the Author Area. The new version will use the same doi as the original submission, which also will remain accessible on the bioRxiv site. If there are changes to any Supplemental data, resubmit all Supplemental files for the paper. If there are no changes to Supplemental data, there is no need to resubmit Supplemental files.
List of Publishers' Preprint Policies
Most research journals allow posting on preprint servers such as bioRxiv prior to publication. A list of journal policies can be found on Wikipedia and SHERPA/RoMEO. Authors should consult these lists and other sources of information before posting on bioRxiv.
DIRECT TRANSFER FROM BIORXIV TO JOURNALS OR PEER REVIEW SERVICES (B2J)
bioRxiv can save authors time in submitting papers to journals or peer review services by transmitting their manuscript files and metadata directly from bioRxiv. This means authors do not have to spend time re-loading manuscript files and re-entering author information at the journal or peer review service website. Partners currently participating in B2J are listed below (scroll to view full list).
- Acta Crystallographica Section D
- Antimicrobial Agents and Chemotherapy
- Applied and Environmental Microbiology
- Autoimmunity Highlights
- Biology Open
- Biophysical Journal
- BMC Bioinformatics
- BMC Biology
- BMC Cancer
- BMC Evolution
- BMC Evolutionary Biology
- BMC Genetics
- BMC Genomics
- BMC Microbiology
- BMC Neuroscience
- BMC Plant Biology
- BMC Veterinary Research
- BMC Zoology
- Brain Topography
- Bulletin of Mathematical Biology
- Clinical and Vaccine Immunology
- Clinical Interventions in Aging
- Disease Models & Mechanisms
- Drug Design, Development and Therapy
- Drug Metabolism and Disposition
- The EMBO Journal
- EMBO Molecular Medicine
- EMBO Reports
- Experimental Brain Research
- G3: Genes, Genomes, Genetics
- Genome Biology
- Genome Research
- Hormones and Cancer
- Infection and Immunity
- International Journal of Chronic Obstructive Pulmonary Disease
- International Journal of Nanomedicine
- International Journal of Systematic and Evolutionary Microbiology
- Invertebrate Neuroscience
- JMM Case Reports
- Journal of Bacteriology
- Journal of Biological Chemistry
- The Journal of Cell Biology
- Journal of Cell Science
- Journal of Clinical Microbiology
- Journal of Experimental Biology
- Journal of Experimental Botany
- The Journal of Experimental Medicine
- The Journal of General Physiology
- Journal of General Virology
- The Journal of Immunology
- Journal of Lipid Research
- Journal of Mammary Gland Biology and Neoplasia
- Journal of Medical Microbiology
- Journal of Molecular Evolution
- Journal of Neural Transmission
- Journal of Neurophysiology
- The Journal of Neuroscience
- Journal of Pain Research
- Journal of Pharmacology and Experimental Therapeutics
- Journal of Virology
- Medicinal Chemistry Research
- Microbial Genomics
- Molecular and Cellular Biology
- Molecular & Cellular Proteomics
- Molecular Biology of the Cell
- Molecular Pharmacology
- Molecular Systems Biology
- Neuropsychiatric Disease and Treatment
- OncoTargets and Therapy
- Patient Preference and Adherence
- Pharmaceutical Research
- Photosynthesis Research
- The Plant Cell
- Plant Cell, Tissue and Organ Culture
- Plant Direct
- Plant Molecular Biology
- Plant Physiology
- PLOS Computational Biology
- PLOS Genetics
- PLOS Medicine
- PLOS Neglected Tropical Diseases
- PLOS One
- PLOS Pathogens
- Therapeutics and Clinical Risk Management
- Theoretical and Applied Genetics