Biochemistry

Multiplexed selectivity screening of anti-GPCR antibodies
Leo Dahl, Ilana B. Kotliar, Annika Bendes, Tea Dodig-Crnković, Samuel Fromm, Arne Elofsson, Mathias Uhlén, Thomas P. Sakmar, Jochen M. Schwenk

bioRxiv 2022.11.24.517810; doi: https://doi.org/10.1101/2022.11.24.517810 New Results

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Optimal clustering for quantum refinement of biomolecular structures: Q|R#4
Yaru Wang, Holger Kruse, Nigel W. Moriarty, Mark P. Waller, Pavel V. Afonine, Malgorzata Biczysko

bioRxiv 2022.11.24.517825; doi: https://doi.org/10.1101/2022.11.24.517825 New Results

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The structural basis of the multi-step allosteric activation of Aurora B kinase
Dario Segura-Peña, Oda Hovet, Hemanga Gogoi, Jennine M. Dawicki-McKenna, Stine Malene Hansen Wøien, Manuel Carrer, Ben E. Black, Michele Cascella, Nikolina Sekulić

bioRxiv 2022.11.23.517677; doi: https://doi.org/10.1101/2022.11.23.517677 New Results

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Structure and function of Plasmodium actin II in the parasite mosquito stages
Andrea J. Lopez, Maria Andreadaki, Juha Vahokoski, Elena Deligianni, Lesley J. Calder, Serena Camerini, Anika Freitag, Ulrich Bergmann, Peter B. Rosenthal, Inga Sidén-Kiamos, Inari Kursula

bioRxiv 2022.11.22.517348; doi: https://doi.org/10.1101/2022.11.22.517348 New Results

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Pretrained language models and weight redistribution achieve precise k_cat prediction
Han Yu, Xiaozhou Luo

bioRxiv 2022.11.23.517595; doi: https://doi.org/10.1101/2022.11.23.517595 New Results

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Mix-and-extrude using 3D printed nozzles for time-resolved membrane protein crystallography
Mohammad Vakili, Huijong Han, Christina Schmidt, Agnieszka Wrona, Marco Kloos, Iñaki de Diego, Katerina Dörner, Joana Valerio, Ekaterina Round, Kristina Lorenzen, Joachim Schulz

bioRxiv 2022.11.23.517685; doi: https://doi.org/10.1101/2022.11.23.517685 New Results

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Structural and biochemical insights into heterotetramer formation between human oncogenic K-Ras4B^G12V and Rgl2, a RalA/B activator
Mishal Tariq, Teppei Ikeya, Naoyuki Togashi, Louise Fairall, Carlos Bueno-Alejo, Syun Kamei, Beatriz Romartinez-Alonso, Miguel Angel Muro Campillo, Andrew J. Hudson, Yutaka Ito, John W.R. Schwabe, Cyril Dominguez, Kayoko Tanaka

bioRxiv 2022.10.10.511529; doi: https://doi.org/10.1101/2022.10.10.511529 New Results

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Structure of LRRK1 and mechanisms of autoinhibition and activation
Janice M. Reimer, Andrea M. Dickey, Yu Xuan Lin, Robert G. Abrisch, Sebastian Mathea, Deep Chatterjee, Elizabeth J. Fay, Stefan Knapp, Matthew D. Daugherty, Samara L. Reck-Peterson, Andres E. Leschziner

bioRxiv 2022.11.22.517582; doi: https://doi.org/10.1101/2022.11.22.517582 New Results

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Mechanism of RanGTP priming the release of H2A-H2B from Kap114 and Importin-9
Jenny Jiou, Joy M. Shaffer, Natalia E. Bernades, Kiran Tripathi, Ho Yee J. Fung, Oladimeji S. Olaluwoye, Juliana Kikumoto Dias, Yuh Min Chook, Sheena D’Arcy

bioRxiv 2022.11.22.517512; doi: https://doi.org/10.1101/2022.11.22.517512 New Results

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Acyl-CoA dehydrogenase substrate promiscuity limits the potential for development of substrate reduction therapy in disorders of valine and isoleucine metabolism
Sander M. Houten, Tetyana Dodatko, William Dwyer, Hongjie Chen, Brandon Stauffer, Robert J. DeVita, Frédéric M. Vaz, Chunli Yu, João Leandro

bioRxiv 2022.11.22.517273; doi: https://doi.org/10.1101/2022.11.22.517273 New Results

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Biochemistry

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