Biochemistry

Conformational stability and dynamics in crystals recapitulate protein behaviour in solution
BM Sala, T Le Marchand, G Pintacuda, C Camilloni, A Natalello, S Ricagno

bioRxiv 2020.04.27.063909; doi: https://doi.org/10.1101/2020.04.27.063909

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Tetramerisation of the CRISPR ring nuclease Csx3 facilitates cyclic oligoadenylate cleavage
Januka S. Athukoralage, Stuart McQuarrie, Sabine Grüschow, Shirley Graham, Tracey M. Gloster, Malcolm F. White

bioRxiv 2020.04.28.066118; doi: https://doi.org/10.1101/2020.04.28.066118

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The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
Courtney Mycroft-West, Dunhao Su, Stefano Elli, Yong Li, Scott Guimond, Gavin Miller, Jeremy Turnbull, Edwin Yates, Marco Guerrini, David Fernig, Marcelo Lima, Mark Skidmore

bioRxiv 2020.02.29.971093; doi: https://doi.org/10.1101/2020.02.29.971093

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Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug Carmofur
Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W. Guddat, Gengfu Xiao, Leike Zhang, Haitao Yang, Zihe Rao

bioRxiv 2020.04.09.033233; doi: https://doi.org/10.1101/2020.04.09.033233

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A multiplexed work-flow for absolute quantification of Klebsiella oxytoca Nif proteins
Christoph James Waite, Anya Lindstrom Battle, Mark Bennett, Martin Buck, Jörg Schumacher

bioRxiv 2020.04.27.064014; doi: https://doi.org/10.1101/2020.04.27.064014

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Perturbed structural dynamics underlie inhibition and altered specificity of the multidrug efflux pump AcrB
Eamonn Reading, Zainab Ahdash, Chiara Fais, Vito Ricci, Xuan Wang Kan, Elizabeth Grimsey, Jack Stone, Giuliano Malloci, Andy M. Lau, Heather Findlay, Albert Konijnenberg, Paula J. Booth, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock, Argyris Politis

bioRxiv 2020.04.27.063511; doi: https://doi.org/10.1101/2020.04.27.063511

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Biochemical Basis for the Regulation of Biosynthesis of Antiparasitics by Bacterial Hormones
Iti Kapoor, Philip Olivares, Satish K. Nair

bioRxiv 2020.04.27.064931; doi: https://doi.org/10.1101/2020.04.27.064931

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In vitro Evolution of Antibody Affinity via Insertional Mutagenesis Scanning of an Entire Antibody Variable Region
Kalliopi Skamaki, Stephane Emond, Matthieu Chodorge, John Andrews, D. Gareth Rees, Daniel Cannon, Bojana Popovic, Andrew Buchanan, Ralph Minter, Florian Hollfelder

bioRxiv 2020.04.26.062786; doi: https://doi.org/10.1101/2020.04.26.062786

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Dissecting the structural and functional roles of a vicinal iron-binding site in encapsulated ferritins
Cecilia Piergentili, Jennifer Ross, Didi He, Kelly J. Gallagher, Will A. Stanley, Laurène Adam, C. Logan Mackay, Kevin J. Waldron, David J. Clarke, Jon Marles-Wright

bioRxiv 785121; doi: https://doi.org/10.1101/785121

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Biomarker model for cancer: Development of fast LC-MS/MS method for reduced and oxidized glutathione
Ray F. Nassar, Praneeth Chitralia, Roger Rushworth, Charles O’Donnell, Iswarya Gagrin

bioRxiv 2020.04.26.058412; doi: https://doi.org/10.1101/2020.04.26.058412

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Biochemistry

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