Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite
Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K. Griffin, Kanayo Satoh, David H. Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel A. Burguillos, Roger B. Dodd, Fusheng Chen, Yalun Zhang, Patrick Flagmeier, Lisa-Maria Needham, Masahiro Enomoto, Seema Qamar, James Henderson, Jochen Walter, Paul E. Fraser, David Klenerman, Steven F. Lee, Peter St George-Hyslop, Guy C. Brown
bioRxiv 2020.12.03.409995; doi: https://doi.org/10.1101/2020.12.03.409995