Biochemistry

Biased agonists of the chemokine receptor CXCR3 differentially drive formation of G_αi:β-arrestin complexes
Kevin Zheng, Jeffrey S. Smith, Anmol Warman, Issac Choi, Jaimee N. Gundry, Thomas F. Pack, Asuka Inoue, Marc G. Caron, Sudarshan Rajagopal

bioRxiv 2020.06.11.146605; doi: https://doi.org/10.1101/2020.06.11.146605

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2-amino-1,3-benzothiazole-6-carboxamide Preferentially Binds the Tandem Mismatch Motif r(UY:GA)
Andrew T. Chang, Lu Chen, Luo Song, Shuxing Zhang, Edward P. Nikonowicz

bioRxiv 2020.06.11.146761; doi: https://doi.org/10.1101/2020.06.11.146761

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14-3-3 protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2
Neha Jain, Petra Janning, Heinz Neumann

bioRxiv 2020.06.09.142752; doi: https://doi.org/10.1101/2020.06.09.142752

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Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger Cyclin K degradation
Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yue Cui, Qingcui Wu, Jiaojiao Li, Jian-Hua Wang, Meng-Qiu Dong, Xiangbing Qi, Ting Han

bioRxiv 2020.06.10.144303; doi: https://doi.org/10.1101/2020.06.10.144303

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Combining small-molecule bioconjugation and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to expose allostery: the case of human cytochrome P450 3A4
Julie Ducharme, Christopher J. Thibodeaux, Karine Auclair

bioRxiv 2020.06.09.142851; doi: https://doi.org/10.1101/2020.06.09.142851

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The Ketosynthase Domain Constrains the Design of Polyketide Synthases
Maja Klaus, Lynn Buyachuihan, Martin Grininger

bioRxiv 2020.01.23.916668; doi: https://doi.org/10.1101/2020.01.23.916668

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The low-density lipoprotein receptor-related protein-1 is essential for Dengue virus infection
Vivian Huerta, Alejandro M. Martin, Mónica Sarría, Osmany Guirola, Alexis Yero, Yassel Ramos, Dianne Pupo, Dayron Martin, Alessandro Marcello, Glay Chinea

bioRxiv 2020.06.10.144089; doi: https://doi.org/10.1101/2020.06.10.144089

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Increased glycolysis is an early outcome of palmitate-mediated lipotoxicity
Pâmela Kakimoto, Antonio Zorzano, Alicia J. Kowaltowski

bioRxiv 2020.06.10.144808; doi: https://doi.org/10.1101/2020.06.10.144808

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Translesion Synthesis by MmLV-, AMV-, and HIV-Reverse Transcriptases Using RNA Templates Containing Inosine, Guanosine, and Their 8-oxo-7,8-Dihydropurine Derivatives
Madeline Glennon, Austin Skinner, Mara Krutsinger, Marino J. E. Resendiz

bioRxiv 2020.06.10.144048; doi: https://doi.org/10.1101/2020.06.10.144048

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The linear ubiquitin chain assembly complex LUBAC generates heterotypic ubiquitin chains
Alan Rodriguez Carvajal, Carlos Gomez Diaz, Antonia Vogel, Adar Sonn-Segev, Katrin Schodl, Luiza Deszcz, Zsuzsanna Orban-Nemeth, Shinji Sakamoto, Karl Mechtler, Philipp Kukura, Tim Clausen, David Haselbach, Fumiyo Ikeda

bioRxiv 2020.05.27.117952; doi: https://doi.org/10.1101/2020.05.27.117952

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Biochemistry

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