Biochemistry

Mix-and-extrude using 3D printed nozzles for time-resolved membrane protein crystallography
Mohammad Vakili, Huijong Han, Christina Schmidt, Agnieszka Wrona, Marco Kloos, Iñaki de Diego, Katerina Dörner, Joana Valerio, Ekaterina Round, Kristina Lorenzen, Joachim Schulz

bioRxiv 2022.11.23.517685; doi: https://doi.org/10.1101/2022.11.23.517685 New Results

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Structural and biochemical insights into heterotetramer formation between human oncogenic K-Ras4B^G12V and Rgl2, a RalA/B activator
Mishal Tariq, Teppei Ikeya, Naoyuki Togashi, Louise Fairall, Carlos Bueno-Alejo, Syun Kamei, Beatriz Romartinez-Alonso, Miguel Angel Muro Campillo, Andrew J. Hudson, Yutaka Ito, John W.R. Schwabe, Cyril Dominguez, Kayoko Tanaka

bioRxiv 2022.10.10.511529; doi: https://doi.org/10.1101/2022.10.10.511529 New Results

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Mechanism of RanGTP priming the release of H2A-H2B from Kap114 and Importin-9
Jenny Jiou, Joy M. Shaffer, Natalia E. Bernades, Kiran Tripathi, Ho Yee J. Fung, Oladimeji S. Olaluwoye, Juliana Kikumoto Dias, Yuh Min Chook, Sheena D’Arcy

bioRxiv 2022.11.22.517512; doi: https://doi.org/10.1101/2022.11.22.517512 New Results

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Acyl-CoA dehydrogenase substrate promiscuity limits the potential for development of substrate reduction therapy in disorders of valine and isoleucine metabolism
Sander M. Houten, Tetyana Dodatko, William Dwyer, Hongjie Chen, Brandon Stauffer, Robert J. DeVita, Frédéric M. Vaz, Chunli Yu, João Leandro

bioRxiv 2022.11.22.517273; doi: https://doi.org/10.1101/2022.11.22.517273 New Results

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Insights into the biosynthesis of icumazole unveiling a distinctive family of crotonyl-CoA carboxylase/reductase
Feng Xie, Alexander F. Kiefer, Anna K. H. Hirsch, Olga Kalinina, Chengzhang Fu, Rolf Müller

bioRxiv 2022.11.22.517467; doi: https://doi.org/10.1101/2022.11.22.517467 New Results

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Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin
Matthew G. Alteen, Justin C. Deme, Claudia P. Alvarez, Peter Loppnau, Ashley Hutchinson, Alma Seitova, Renu Chandrasekaran, Eduardo Silva Ramos, Christopher Secker, Mona Alqazzaz, Erich E. Wanker, Susan M. Lea, Cheryl H Arrowsmith, Rachel J. Harding

bioRxiv 2022.11.21.516512; doi: https://doi.org/10.1101/2022.11.21.516512 New Results

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AlphaFold predictions: great hypotheses but no match for experiment
Thomas C. Terwilliger, Dorothee Liebschner, Tristan I. Croll, Christopher J. Williams, Airlie J. McCoy, Billy K. Poon, Pavel V. Afonine, Robert D. Oeffner, Jane S. Richardson, Randy J. Read, Paul D. Adams

bioRxiv 2022.11.21.517405; doi: https://doi.org/10.1101/2022.11.21.517405 New Results

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O-GlcNAcylation promotes YTHDF1 cytosolic localization and colorectal cancer tumorigenesis
Jie Li, Muhammad Ahmad, Lei Sang, Yahui Zhan, Yibo Wang, Yonghong Yan, Yue Liu, Weixiao Mi, Mei Lu, Yu Dai, Rou Zhang, Meng-Qiu Dong, Yun-Gui Yang, Xiaohui Wang, Jianwei Sun, Jing Li

bioRxiv 2022.11.21.517456; doi: https://doi.org/10.1101/2022.11.21.517456 New Results

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AlphaFold2-based fusion design deciphers crucial role of the E3 UFL1 N-terminal helix in E2 UFC1 binding and ufmylation
Sayanika Banerjee, Julia K Varga, Manoj Kumar, Guy Zoltsman, Michail N Isupov, Rina Rosenzweig, Ora Schueler-Furman, Reuven Wiener

bioRxiv 2022.09.15.508077; doi: https://doi.org/10.1101/2022.09.15.508077 New Results

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Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits
Daisy J. Grove, Daniel J. Levine, Michael G. Kearse

bioRxiv 2022.11.18.517125; doi: https://doi.org/10.1101/2022.11.18.517125 New Results

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Biochemistry

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