Cancer Biology

DNAJB1-PRKACA fusion kinase interacts with β-catenin and liver regenerative response to drive fibrolamellar hepatocellular carcinoma
Edward R. Kastenhuber, Gadi Lalazar, Darjus F. Tschaharganeh, Shauna L. Houlihan, Timour Baslan, Chi-Chao Chen, David Requena, Sha Tian, Benedikt Bosbach, John E. Wilkinson, Sanford M. Simon, Scott W. Lowe

bioRxiv 192104; doi: https://doi.org/10.1101/192104 New Results
The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1
Euan S. Polson, Verena B. Kuchler, Christopher Abbosh, Edith M. Ross, Ryan K. Mathew, Hester A. Beard, Eulashini Chuntharpursat-Bon, Jennifer Williams, Bárbara Da Silva, Hao Shao, Anjana Patel, Adam J. Davies, Alastair Droop, Hollie B. S. Griffiths, Paul Chumas, Susan C. Short, Mihaela Lorger, Jason Gestwicki, Lee D. Roberts, Robin S. Bon, Simon J. Allison, Shoutian Zhu, Florian Markowetz, Heiko Wurdak

bioRxiv 205203; doi: https://doi.org/10.1101/205203 New Results
Non-invasive detection of bladder cancer through the analysis of driver gene mutations and aneuploidy
Simeon U. Springer, Maria Del Carmen Rodriguez Pena, Lu Li, Christopher Douville, Yuxuan Wang, Josh Cohen, Diana Taheri, Natalie Silliman, Joy Schaeffer, Janine Ptak, Lisa Dobbyn, Maria Papoli, Isaac Kinde, Bahman Afsari, Aline C. Tregnago, Stephania M. Bezerra, Christopher VandenBussche, Kazutoshi Fujita, Dilek Ertoy, Isabela W. Cunha, Lijia Yu, Mark Schoenberg, Trinity J. Bivalacqua, Kathleen G. Dickman, Arthur P. Grollman, Luis A. Diaz Jr., Rachel Karchin, Ralph H. Hruban, Cristian Tomasetti, Nickolas Papadopoulos, Ken W. Kinzler, Bert Vogelstein, George J. Netto

bioRxiv 203976; doi: https://doi.org/10.1101/203976 New Results
Analysis of hierarchical organization in gene expression networks reveals underlying principles of collective tumor cell dissemination and metastatic aggressiveness of inflammatory breast cancer
Shubham Tripathi, Mohit Kumar Jolly, Wendy A. Woodward, Herbert Levine, Michael W. Deem

bioRxiv 204388; doi: https://doi.org/10.1101/204388 New Results
Non-invasive detection of upper tract urothelial carcinomas through the analysis of driver gene mutations and aneuploidy in urine
Simeon U. Springer, Chung-Hsin Chen, Lu Li, Christopher Douville, Yuxuan Wang, Josh Cohen, Bahman Afsari, Ludmila Danilova, Natalie Silliman, Joy Schaeffer, Janine Ptak, Lisa Dobbyn, Maria Papoli, Isaac Kinde, Chao-Yuan Huang, Chia-Tung Shun, Rachel Karchin, George J. Netto, Robert J. Turesky, Byeong Hwa Yun, Thomas A. Rosenquist, Ralph H. Hruban, Yeong-Shiau Pu, Arthur P. Grollman, Cristian Tomasetti, Nickolas Papadopoulos, Ken W. Kinzler, Bert Vogelstein, Kathleen G. Dickman

bioRxiv 203968; doi: https://doi.org/10.1101/203968 New Results
The Complex Ecosystem in Non Small Cell Lung Cancer Invasion
Seth Haney, Jessica Konen, Adam I. Marcus, Maxim Bazhenov

bioRxiv 176446; doi: https://doi.org/10.1101/176446 New Results
Super-Resolution Ultrasound Bubble Tracking for Preclinical and Clinical Multiparametric Tumor Characterization
Tatjana Opacic, Stefanie Dencks, Benjamin Theek, Marion Piepenbrock, Dimitri Ackermann, Anne Rix, Twan Lammers, Elmar Stickeler, Stefan Delorme, Georg Schmitz, Fabian Kiessling

bioRxiv 203935; doi: https://doi.org/10.1101/203935 New Results
Combining CRISPR/Cas9 mutagenesis and a small-molecule inhibitor to probe the function of MELK in cancer
Christopher J. Giuliano, Ann Lin, Joan C. Smith, Ann C. Palladino, Jason M. Sheltzer

bioRxiv 203984; doi: https://doi.org/10.1101/203984 New Results
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Drean, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord

bioRxiv 203224; doi: https://doi.org/10.1101/203224 New Results
Optimal Therapy Scheduling Based on a Pair of Collaterally Sensitive Drugs
Nara Yoon, Robert Vander Velde, Andriy Marusyk, Jacob Scott

bioRxiv 196824; doi: https://doi.org/10.1101/196824 Confirmatory Results

Cancer Biology

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