Cancer Biology

Overcoming Immunological Resistance Enhances the Efficacy of a Novel anti-tMUC1 CAR T Cell Treatment Against Pancreatic Ductal Adenocarcinoma
Mahboubeh Yazdanifar, Ru Zhou, Priyanka Grover, Chandra Williams, Mukulika Bose, Laura Jeffords Moore, Shu-ta Wu, Richard Chi, John Maher, Didier Dreau, Pinku Mukherjee

bioRxiv 642934; doi: https://doi.org/10.1101/642934 New Results
Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumour fate
Sina Jostes, Martin Fellermeyer, Gina Merges, Glen Kristiansen, Daniel Nettersheim, Hubert Schorle

bioRxiv 643114; doi: https://doi.org/10.1101/643114 New Results
Knowledge-guided analysis of 'omics' data using the KnowEnG cloud platform
Charles Blatti III, Amin Emad, Matthew J. Berry, Lisa Gatzke, Milt Epstein, Daniel Lanier, Pramod Rizal, Jing Ge, Xiaoxia Liao, Omar Sobh, Mike Lambert, Corey S. Post, Jinfeng Xiao, Peter Groves, Aidan T. Epstein, Xi Chen, Subhashini Srinivasan, Erik Lehnert, Krishna R. Kalari, Liewei Wang, Richard M. Weinshilboum, Jun S. Song, C. Victor Jongeneel, Jiawei Han, Umberto Ravaioli, Nahil Sobh, Colleen B. Bushell, Saurabh Sinha

bioRxiv 642124; doi: https://doi.org/10.1101/642124 New Results
Thermal cycling-hyperthermia in combination with polyphenols, epigallocatechin gallate and chlorogenic acid, exerts synergistic anticancer effect against human pancreatic cancer PANC-1 cells
Chueh-Hsuan Lu, Wei-Ting Chen, Chih-Hsiung Hsieh, Yu-Yi Kuo, Chih-Yu Chao

bioRxiv 548552; doi: https://doi.org/10.1101/548552 New Results
Comprehensive Genomic Characterization of Breast Tumors with BRCA1 and BRCA2 Mutations
Avantika Lal, Daniele Ramazzotti, Ziming Weng, Keli Liu, James Ford, Arend Sidow

bioRxiv 409813; doi: https://doi.org/10.1101/409813 New Results
Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8⁺ T-cell exhaustion in cancer
Kyungsoo Kim, Seyeon Park, Ga Min Kim, Su Myeong Park, Seong Yong Park, Da Hee Kim, Young Min Park, Yoon Woo Koh, Hye Ryun Kim, Sang-Jun Ha, Insuk Lee

bioRxiv 641316; doi: https://doi.org/10.1101/641316 New Results
Landscape of tumor-infiltrating immune cells in human immunogenic cancers:B cells are inversely associated with CD8T cells, but positively correlated with Treg cells
Young Kwang Chae, William Han Bae, Minji Jung, Young Suk Kim, Jonathan Forrest Anker, Keerthi Tamragouri, Maria Matsangou, Francis Joseph Giles

bioRxiv 641712; doi: https://doi.org/10.1101/641712 New Results
PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription
Takahito Ohira, Hirotada Kojima, Yuko Kuroda, Daigo Inaoka, Mitsuhiko Osaki, Hideki Wanibuchi, Futoshi Okada, Mitsuo Oshimura, Hiroyuki Kugoh

bioRxiv 640508; doi: https://doi.org/10.1101/640508 New Results
Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation
Miguel O. Bernabeu, Jakub Köry, James A. Grogan, Bostjan Markelc, Albert Beardo Ricol, Mayeul d’Avezac, Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm Krüger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, Tomás Alarcón, Helen M. Byrne

bioRxiv 640060; doi: https://doi.org/10.1101/640060 New Results
CELF1 is an EIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs
Arindam Chaudhury, Rituraj Pal, Natee Kongchan, Na Zhao, Yingmin Zhu, Emuejevoke Olokpa, Shebna A. Cheema, Sonia del Rincon, Lucas C. Reineke, Sufeng Mao, Richard E. Lloyd, Marco Sardiello, Jeffrey M. Rosen, Joel R. Neilson

bioRxiv 640300; doi: https://doi.org/10.1101/640300 New Results

Cancer Biology

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