Cancer Biology

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated non-degradative ubiquitination of eIF4A1
Huiru Sun, Dongyue Jiao, Xiaying Zhao, Yingji Chen, Qing Shi, Zeheng Lv, Yao Li, Kun Gao, Chenji Wang

bioRxiv 2023.09.27.559872; doi: https://doi.org/10.1101/2023.09.27.559872 New Results

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Tracking genome evolution in single cell clones reveals the rates and features of copy number alterations generated by ongoing chromosomal instability in cancer.
Sarah E McClelland, Molly A Guscott, David Gomez-Peregrina, Alexander Andersen, Tanya Soliman, Caterina Vidal-Horrach, Bjorn Bakker, Diana C.J. Spierings, Rene Wardenaar, Floris Foijer, Cesar Serrano, Roland Schwarz

bioRxiv 2023.09.27.559836; doi: https://doi.org/10.1101/2023.09.27.559836 New Results

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Clonal fitness decline in somatic differentiation hierarchies
Iftikhar Ahmed, David Dingli, Weini Huang, Benjamin Werner

bioRxiv 2023.09.27.559763; doi: https://doi.org/10.1101/2023.09.27.559763 New Results

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The expression of PKM1 and PKM2 in developing, benign, and cancerous prostatic tissues
Lin Li, Siyuan Cheng, Yunshin Yeh, Yingli Shi, Nikayla Henderson, David Price, Xin Gu, Xiuping Yu

bioRxiv 2023.09.27.559832; doi: https://doi.org/10.1101/2023.09.27.559832 New Results

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Lymphoma B cells remodel bone marrow stromal cell organization and function to induce a supportive cancer-associated fibroblast network
Elise Dessauge, Baptiste Brauge, Simon Leonard, David Roulois, Celine Monvoisin, Thomas Lejeune, Jerome Destin, Florence Jouan, Francisco Llamas-Gutierrez, Frederic Mourcin, Karin TARTE

bioRxiv 2023.09.26.559605; doi: https://doi.org/10.1101/2023.09.26.559605 New Results

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The invasive lobular cancer cell line encyclopedia (ICLE) for studying potential biomarkers and exploring therapeutic opportunities
Osama Shiraz Shah, Fangyuan Chen, Abdalla Webn, Anokhi Kashiparekh, Laura Savariau, Benjamin Clifford, Jagmohan Hooda, Jennifer M Atkinson, Steffi Oesterreich, Adrian V Lee

bioRxiv 2023.09.26.559548; doi: https://doi.org/10.1101/2023.09.26.559548 New Results

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Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models
Peter G Hendrickson, Kristianne M Oristian, MaKenna R Browne, Lixia Lou, Yan Ma, Dianna M Cardona, Corinne M Linardic, David G Kirsch

bioRxiv 2023.09.26.559519; doi: https://doi.org/10.1101/2023.09.26.559519 New Results

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Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer
Na Zhao, Elena Kabotyanski, Alexander Saltzman, Anna Malovannaya, Xueying Yuan, Lucas Reineke, Nadia Lieu, Yang Gao, Diego Pedroza, Sebastian Calderon, Alex Smith, Clark Hamor, Kazem Safari, Sara Savage, Bing Zhang, Jianling Zhou, Luisa Soto, Susan Hilsenbeck, Cheng Fan, Charles Perou, Jeffrey Rosen

bioRxiv 2023.09.28.559973; doi: https://doi.org/10.1101/2023.09.28.559973 New Results

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Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer associated fibroblasts
Richard J Burt, Aditi Dey, Ayse Akarca, Hermione Allen, Rodothea Amerikanou, Samantha Atkinson, David Auty, Jenny Chatzigerou, Emily Cutler, Jose Afonso Guerra-Assuncao, Kristina Kirschner, Ruchi Kumari, JIten Manji, Teresa Marafioti, Adele K. Fielding

bioRxiv 2023.09.26.559490; doi: https://doi.org/10.1101/2023.09.26.559490 New Results

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Cancer associated fibroblasts mitigate the efficacy of the combination treatment of chemotherapy and BCL-xL targeting in triple negative breast cancer cells
Lisa Nocquet, Julie Roul, Laurine Duarte, Mario Campone, Philippe P Juin, Frédérique Souazé

bioRxiv 2023.09.26.559287; doi: https://doi.org/10.1101/2023.09.26.559287 New Results

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Cancer Biology

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