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Cancer Biology

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  • Inhibitors of ROCK kinases induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
    Julieta Martino, Sebastián O. Siri, Natalia S. Paviolo, Cintia Garro, María F. Pansa, Sofía Carbajosa, Aaron C. Brown, José L. Bocco, Israel Gloger, Gerard Drewes, Kevin P. Madauss, Gastón Soria, Vanesa Gottifredi
    bioRxiv 2022.06.24.497514; doi: https://doi.org/10.1101/2022.06.24.497514 New Results
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  • Waiting times in a branching process model of colorectal cancer initiation
    Ruibo Zhang, Obinna A. Ukogu, Ivana Bozic
    bioRxiv 2022.06.22.497226; doi: https://doi.org/10.1101/2022.06.22.497226 New Results
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  • Adrenal cortex size, homeostasis and tumorigenesis is regulated by gonadal hormones via androgen receptor/β-catenin signalling crosstalk
    Rodanthi Lyraki, Anaëlle Grabek, Amélie Tison, Mirko Peitzsch, Nicole Bechman, Sameh A Youssef, Alain de Bruin, Elvira R.M. Bakker, Frank Claessens, Marie-Christine Chaboissier, Andreas Schedl
    bioRxiv 2022.06.23.497219; doi: https://doi.org/10.1101/2022.06.23.497219 New Results
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  • Assessing Functional Androgen Receptor Pathway Activity in Response to Radiotherapy Using hK2-targeted PET Imaging
    Claire M Storey, Mohamed Altai, Mesude Bicak, Darren R Veach, Katharina Lückerath, Gabriel Adrian, Michael R McDevitt, Teja Kalidindi, Julie E Park, Ken Herrmann, Diane Abou, Wahed Zedan, Norbert Peekhaus, Robert J Klein, Robert Damoiseaux, Steven M Larson, Hans Lilja, Daniel Thorek, David Ulmert
    bioRxiv 2022.06.23.497290; doi: https://doi.org/10.1101/2022.06.23.497290 New Results
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  • Improving Mathematical Models of Cancer through Game-Theoretic Modelling: A Study in Non-Small Cell Lung Cancer
    Virginia Ardévol Martínez, Monica Salvioli, Narmin Ghaffari Laleh, Frank Thuijsman, Joel S. Brown, Rachel Cavill, Jakob Nikolas Kather, Kateřina Staňková
    bioRxiv 2021.10.29.466444; doi: https://doi.org/10.1101/2021.10.29.466444 New Results
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  • Development of 5-FU-modified tumor suppressor microRNAs as a platform for novel microRNA-based cancer therapeutics
    John G. Yuen, Andrew Fesler, Ga-Ram Hwang, Lan-Bo Chen, Jingfang Ju
    bioRxiv 2022.06.23.497408; doi: https://doi.org/10.1101/2022.06.23.497408 New Results
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  • CIGB-300 peptide targets the CK2 phospho-acceptor domain on Human Papillomavirus E7 and disrupts the Retinoblastoma (RB) complex in cervical cancer cells
    Ailyn C. Ramón, Om Basukala, Paola Massimi, Miranda Thomas, Yasser Perera, Lawrence Banks, Silvio E. Perea
    bioRxiv 2022.06.23.497243; doi: https://doi.org/10.1101/2022.06.23.497243 New Results
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  • Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes
    Navonil De Sarkar, Robert D. Patton, Anna-Lisa Doebley, Brian Hanratty, Adam J. Kreitzman, Jay F. Sarthy, Minjeong Ko, Mohamed Adil, Sandipan Brahma, Michael P. Meers, Derek H. Janssens, Lisa A. Ang, Ilsa Coleman, Arnab Bose, Ruth F. Dumpit, Jared M. Lucas, Talina A. Nunez, Holly M. Nguyen, Heather M. McClure, Colin C. Pritchard, Michael T. Schweizer, Colm Morrissey, Atish D. Choudhury, Sylvan C. Baca, Jacob E. Berchuck, Matthew L. Freedman, Kami Ahmad, Michael C. Haffner, Bruce Montgomery, Eva Corey, Steven Henikoff, Peter S. Nelson, Gavin Ha
    bioRxiv 2022.06.21.496879; doi: https://doi.org/10.1101/2022.06.21.496879 New Results
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  • EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry
    Haitao Luan, Timothy A. Bielecki, Bhopal C. Mohapatra, Namista Islam, Insha Mushtaq, Aaqib M. Bhat, Sameer Mirza, Sukanya Chakraborty, Mohsin Raza, Matthew D. Storck, Jane L. Meza, Wallace B. Thoreson, Donald W. Coulter, Emad A. Rakha, Vimla Band, Hamid Band
    bioRxiv 2022.06.21.497035; doi: https://doi.org/10.1101/2022.06.21.497035 New Results
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  • Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress
    Juan J. Apiz-Saab, Lindsey N. Dzierozynski, Patrick B. Jonker, Zhou Zhu, Riona N. Chen, Moses Oh, Colin Sheehan, Kay F. Macleod, Christopher R. Weber, Alexander Muir
    bioRxiv 2022.06.21.497008; doi: https://doi.org/10.1101/2022.06.21.497008 New Results
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