Cancer Biology

Comprehensive Genomic Characterization of Breast Tumors with BRCA1 and BRCA2 Mutations
Avantika Lal, Daniele Ramazzotti, Ziming Weng, Keli Liu, James M. Ford, Arend Sidow

bioRxiv 409813; doi: https://doi.org/10.1101/409813 New Results
Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8⁺ T-cell exhaustion in cancer
Kyungsoo Kim, Seyeon Park, Ga Min Kim, Su Myeong Park, Seong Yong Park, Da Hee Kim, Young Min Park, Yoon Woo Koh, Hye Ryun Kim, Sang-Jun Ha, Insuk Lee

bioRxiv 641316; doi: https://doi.org/10.1101/641316 New Results
Landscape of tumor-infiltrating immune cells in human immunogenic cancers:B cells are inversely associated with CD8T cells, but positively correlated with Treg cells
Young Kwang Chae, William Han Bae, Minji Jung, Young Suk Kim, Jonathan Forrest Anker, Keerthi Tamragouri, Maria Matsangou, Francis Joseph Giles

bioRxiv 641712; doi: https://doi.org/10.1101/641712 New Results
PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription
Takahito Ohira, Hirotada Kojima, Yuko Kuroda, Daigo Inaoka, Mitsuhiko Osaki, Hideki Wanibuchi, Futoshi Okada, Mitsuo Oshimura, Hiroyuki Kugoh

bioRxiv 640508; doi: https://doi.org/10.1101/640508 New Results
Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation
Miguel O. Bernabeu, Jakub Köry, James A. Grogan, Bostjan Markelc, Albert Beardo Ricol, Mayeul d’Avezac, Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm Krüger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, Tomás Alarcón, Helen M. Byrne

bioRxiv 640060; doi: https://doi.org/10.1101/640060 New Results
CELF1 is an EIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs
Arindam Chaudhury, Rituraj Pal, Natee Kongchan, Na Zhao, Yingmin Zhu, Emuejevoke Olokpa, Shebna A. Cheema, Sonia del Rincon, Lucas C. Reineke, Sufeng Mao, Richard E. Lloyd, Marco Sardiello, Jeffrey M. Rosen, Joel R. Neilson

bioRxiv 640300; doi: https://doi.org/10.1101/640300 New Results
Myeloid Lineage Enhancers Drive Oncogene Synergy in CEBPA/CSF3R Mutant Acute Myeloid Leukemia
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Sophia Jeng, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson

bioRxiv 639617; doi: https://doi.org/10.1101/639617 New Results
SF3B1 cancer-related mutations cause vulnerability to further perturbations in the U2 snRNP complex in C. elegans
Xènia Serrat, Dmytro Kukhtar, Eric Cornes, Anna Esteve-Codina, Helena Benlloch, Germano Cecere, Julián Cerón

bioRxiv 634634; doi: https://doi.org/10.1101/634634 New Results
Degree and site of chromosomal instability define its oncogenic potential
W.H.M. Hoevenaar, A. Janssen, A.I. Quirindongo, H. Ma, S. Klaasen, A. Teixeira, G.J.A. Offerhaus, R.H. Medema, N. Jelluma, G.J.P.L. Kops

bioRxiv 638460; doi: https://doi.org/10.1101/638460 New Results
Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
Yuetong Wang, Jian Zhang, Shengxiang Ren, Dan Sun, Hsin-Yi Huang, Hua Wang, Yujuan Jin, Fuming Li, Chao Zheng, Liu Yang, Lei Deng, Zhonglin Jiang, Tao Jiang, Xiangkun Han, Shenda Hou, Chenchen Guo, Fei Li, Dong Gao, Jun Qin, Daming Gao, Luonan Chen, Kwok-Kin Wong, Cheng Li, Liang Hu, Caicun Zhou, Hongbin Ji

bioRxiv 638007; doi: https://doi.org/10.1101/638007 New Results

Cancer Biology

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