Cancer Biology

Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R inhibitors
Alison M. Nagle, Kevin M. Levine, Nilgun Tasdemir, Julie A. Scott, Kara Burlbaugh, Justin Kehm, Tiffany A. Katz, David N. Boone, Britta M. Jacobsen, Jennifer M. Atkinson, Steffi Oesterreich, Adrian V. Lee

bioRxiv 253278; doi: https://doi.org/10.1101/253278

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Genome analysis and data sharing informs timing of molecular events in pancreatic neuroendocrine tumour
Rene Quevedo, Anna Spreafico, Jeff Bruce, Arnavaz Danesh, Amanda Giesler, Youstina Hanna, Cherry Have, Tiantian Li, S.Y. Cindy Yang, Tong Zhang, Sylvia L. Asa, Benjamin Haibe-Kains, Suzanne Kamel-Reid, Monika Krzyzanowska, Adam Smith, Simron Singh, Lillian L. Siu, Trevor J. Pugh

bioRxiv 232850; doi: https://doi.org/10.1101/232850

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Phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer
Cun Wang, Haojie Jin, Dongmei Gao, Bastiaan Evers, Guangzhi Jin, Zheng Xue, Liqin Wang, Roderick Beijersbergen, Wenxin Qin, René Bernards

bioRxiv 252452; doi: https://doi.org/10.1101/252452

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HDL-AuNPs-BMS nanoparticle conjugates as molecularly targeted therapy for leukemia
Na Shen, Fei Yan, Jiuxia Pang, Zhe Gao, Aref Al-Kali, Christy L. Haynes, Mark R. Litzow, Shujun Liu

bioRxiv 250985; doi: https://doi.org/10.1101/250985

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Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer
Binod Kumar, Avi Z. Rosenberg, Su Mi Choi, Karen Fox-Talbot, Angelo M. De Marzo, Larisa Nonn, W. Nathaniel Brennen, Luigi Marchionni, Marc K. Halushka, Shawn E. Lupold

bioRxiv 251090; doi: https://doi.org/10.1101/251090

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Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
Jason M. Rohde, Kyle R. Brimacombe, Li Liu, Michael E. Pacold, Adam Yasgar, Dorian M. Cheff, Tobie D. Lee, Ganesha Rai, Bolormaa Baljinnyam, Zhuyin Li, Anton Simeonov, Matthew D. Hall, Min Shen, David M. Sabatini, Matthew B. Boxer

bioRxiv 250340; doi: https://doi.org/10.1101/250340

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5-hydroxy-4′-nitro-7-propionyloxy-genistein inhibited invasion and metastasis via inactivating wnt/β-catenin signal pathway in human endometrial carcinoma JEC cells
Jun Bai, Binjian Yang, Xin Luo

bioRxiv 250605; doi: https://doi.org/10.1101/250605

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Evolution of an intratumoral ecology susceptible to successive treatment in breast cancer xenografts
Hyunsoo Kim, Pooja Kumar, Francesca Menghi, Javad Noorbakhsh, Eliza Cerveira, Mallory Ryan, Qihui Zhu, Guruprasad Ananda, Joshy George, Henry C. Chen, Susan Mockus, Chengsheng Zhang, Yan Yang, James Keck, R. Krishna Murthy Karuturi, Carol J. Bult, Charles Lee, Edison T. Liu, Jeffrey H. Chuang

bioRxiv 249797; doi: https://doi.org/10.1101/249797

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MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence and angiogenic signaling
Cristina Espinosa-Diez, RaeAnna Wilson, Namita Chatterjee, Clayton Hudson, Rebecca Ruhl, Christina Hipfinger, Erin Helms, Omar F. Khan, Daniel G. Anderson, Sudarshan Anand

bioRxiv 132258; doi: https://doi.org/10.1101/132258

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Classifying bladder cancer subtypes
Cihan Kaya, Nicolas Arcenio Pabon

bioRxiv 250258; doi: https://doi.org/10.1101/250258

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Cancer Biology

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