Cancer Biology

Super-enhancer driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability
Pietro Berico, Maguelone Nogaret, Giovanni Gambi, Guillaume Davidson, Max Cigrang, Bujamin H Vokshi, Stephanie Le Gras, Gabrielle Mengus, Tao Ye, Mélanie Dalmasso, Emmanuel Compe, Corine Bertolotto, Irwin Davidson, Frédéric Coin

bioRxiv 2023.01.18.524519; doi: https://doi.org/10.1101/2023.01.18.524519 New Results

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Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model
Roxana M. Pfefferkorn, Benedikt M. Mortzfeld, Christine Fink, Jakob von Frieling, Judith Bossen, Daniela Esser, Christoph Kaleta, Philip Rosenstiel, Holger Heine, Thomas Roeder

bioRxiv 2023.01.18.524563; doi: https://doi.org/10.1101/2023.01.18.524563 New Results

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Targeting PPT1 with ezurpimtrostat sensitives liver tumor to immunotherapy by switching cold into hot microenvironments
Eloïne Bestion, Madani Rachid, Annemilaï Tijeras-Raballand, Gael Roth, Thomas Decaens, Christelle Ansaldi, Soraya Mezouar, Eric Raymond, Philippe Halfon

bioRxiv 2023.01.18.524541; doi: https://doi.org/10.1101/2023.01.18.524541 New Results

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“Tumor Treating Fields” delivered via electromagnetic induction have varied effects across glioma cell lines and electric field amplitudes
Rea Ravin, Teddy X. Cai, Aiguo Li, Nicole Briceno, Randall H. Pursley, Marcial Garmendia-Cedillos, Tom Pohida, Herui Wang, Zhengping Zhuang, Jing Cui, Nicole Y. Morgan, Nathan H. Williamson, Mark R. Gilbert, Peter J. Basser

bioRxiv 2023.01.18.524504; doi: https://doi.org/10.1101/2023.01.18.524504 New Results

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p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs
Jamie L. Grit, Lauren E. McGee, Elizabeth A. Tovar, Curt J. Essenburg, Emily Wolfrum, Ian Beddows, Kaitlin Williams, Rachael Sheridan, Josh Schipper, Marie Adams, Menusha Arumugam, Thomas Vander Woude, Sharavana Gurunathan, Jeffrey M. Field, Julia Wulfkuhle, Emanuel F. Petricoin III, Carrie R. Graveel, Matthew R. Steensma

bioRxiv 2023.01.18.523629; doi: https://doi.org/10.1101/2023.01.18.523629 New Results

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Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
Yuewei Xu, Sarah Spear, Yurui Ma, Marc P. Lorentzen, Michael Gruet, Flora McKinney, Yitao Xu, Chiharu Wickremesinghe, Madelen R Shepherd, Iain McNeish, Hector C. Keun, Anke Nijhuis

bioRxiv 2023.01.18.524417; doi: https://doi.org/10.1101/2023.01.18.524417 New Results

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MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma
Elina Fredlund, Stina Andersson, Elien Hilgert, Guadalupe Álvarez-Hernán, Ezequiel Monferrer, Sinan Karakaya, Tomas Gregor, Siebe Loontiens, Jan Willem Bek, Estelle Lecomte, Emma Magnusson, Enrika Miltenyte, Marie Cabirol, Michail Kyknas, Niklas Engström, Marie Arsenian Henriksson, Emma Hammarlund, Rosa Noguera, Frank Speleman, Johan van Nes, Sofie Mohlin

bioRxiv 2023.01.17.524367; doi: https://doi.org/10.1101/2023.01.17.524367 New Results

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MCB-613 exploits a collateral sensitivity in drug resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1
Christopher F. Bassil, Gray R. Anderson, Benjamin Mayro, Kayleigh N. Askin, Peter S. Winter, Samuel Gruber, Tierney M. Hall, Jacob P. Hoj, Christian Cerda-Smith, Haley M. Hutchinson, Shane T. Killarney, Katherine R. Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Anthony R. Martin, Guillaume Robert, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, David M. Lonard, Alexandre Puissant, Kris C. Wood

bioRxiv 2023.01.17.524094; doi: https://doi.org/10.1101/2023.01.17.524094 New Results

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Deprivation of arginine and lysine interferes with growth of patient-derived tumor xenografts
A.M. Wolkersdorfer, B. Bergmann, J. Adelmann, M. Ebbinghaus, E. Günther, M. Gutmann, L. Hahn, R. Hurwitz, T. Lühmann, J. Schueler, L. Schmidt, M. Teifel, L. Meinel, T. Rudel

bioRxiv 2023.01.17.524398; doi: https://doi.org/10.1101/2023.01.17.524398 New Results

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Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs
Jana Samarin, Piotr Fabrowski, Roman Kurilov, Hana Nuskova, Johanna Hummel-Eisenbeiss, Hannelore Pink, Nan Li, Vivienn Weru, Hamed Alborzinia, Umut Yildiz, Laura Grob, Minerva Taubert, Marie Czech, Michael Morgen, Christina Brandstädter, Katja Becker, Lianghao Mao, Ashok Kumar Jayavelu, Angela Goncalves, Ulrike Uhrig, Jeanette Seiler, Yanhong Lyu, Sven Diederichs, Ursula Klingmüller, Martina Muckenthaler, Annette Kopp-Schneider, Aurelio Teleman, Aubry K Miller, Nikolas Gunkel

bioRxiv 2023.01.17.524372; doi: https://doi.org/10.1101/2023.01.17.524372 New Results

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Cancer Biology

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