Cancer Biology

Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensates
Nazanin Farahi, Tamas Lazar, Peter Tompa, Bálint Mészáros, Rita Pancsa

bioRxiv 2023.09.20.558425; doi: https://doi.org/10.1101/2023.09.20.558425 New Results

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A resource-based mechanistic framework for castration-resistant prostate cancer (CRPC)
B. Vibishan, B.V. Harshavardhan, Sutirth Dey

bioRxiv 2023.09.19.558379; doi: https://doi.org/10.1101/2023.09.19.558379 New Results

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T_reg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma
Xiaodan Qin, Andrew Lam, Xu Zhang, Satyaki Sengupta, J. Bryan Iorgulescu, Tao Zuo, Alexander E. Floru, Grace Meara, Liang Lin, Kenneth Lloyd, Lauren Kwok, Kaylee Smith, Raghavendar T. Nagaraju, Rob Meijers, Craig Ceol, Ching-Ti Liu, Sanda Alexandrescu, Catherine J. Wu, Derin B. Keskin, Rani E. George, Hui Feng

bioRxiv 2022.10.03.510561; doi: https://doi.org/10.1101/2022.10.03.510561 New Results

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Alternate splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer
Zaineb Javed, Dong Hui Shin, Weihua Pan, Sierra R. White, Yeon Soo Kim, Amal Taher Elhaw, Shriya Kamlapurkar, Ya-Yun Cheng, J Cory Benson, Ahmed Emam Abdelnaby, Rebecca Phaeton, Hong-Gang Wang, Shengyu Yang, Mara L.G. Sullivan, Simon C. Watkins, Steven J. Mullett, Stacy L. Gelhaus, Nam Lee, Lan G. Coffman, Katherine M. Aird, Mohamed Trebak, Karthikeyan Mythreye, Vonn Walter, Nadine Hempel

bioRxiv 2023.09.20.558501; doi: https://doi.org/10.1101/2023.09.20.558501 New Results

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Patient-Derived Medullary Thyroid Cancer Organoids; a Model for Patient-tailored Drug and PET-Tracer Screening
Luc H.J. Sondorp, Eline C. Jager, Inês F. Antunes, Rufina Maturi, Liesbeth Jansen, Wouter T. Zandee, Adrienne H. Brouwers, Thera P. Links, Robert P. Coppes, Schelto Kruijff

bioRxiv 2023.09.18.558266; doi: https://doi.org/10.1101/2023.09.18.558266 New Results

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Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation
Jeffrey West, Frederika Rentzeperis, Casey Adam, Rafael Bravo, Kimberly A. Luddy, Mark Robertson-Tessi, Alexander R. A. Anderson

bioRxiv 2022.06.03.493752; doi: https://doi.org/10.1101/2022.06.03.493752 New Results

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Single-cell analysis characterizes PLK1 as a catalyst of an immunosuppressive tumor microenvironment in LUAD
Yifan Kong, Chaohao Li, Jinpeng Liu, Min Zhang, Derek B. Allison, Faisal Hassan, Daheng He, Xinyi Wang, Fengyi Mao, Qiongsi Zhang, Yanquan Zhang, Zhiguo Li, Sai Wu, Chi Wang, Xiaoqi Liu

bioRxiv 2023.08.02.551692; doi: https://doi.org/10.1101/2023.08.02.551692 New Results

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Leveraging the p53 signaling pathway as a radio-sensitization strategy in endometrial cancer
Roberto Vargas, Aaron Petty, Brian Yard, Arda Durmaz, Kristi Lin-Rahardja, Ofer Reizes, Robert Debernardo, Jacob Scott

bioRxiv 2022.09.06.505009; doi: https://doi.org/10.1101/2022.09.06.505009 New Results

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Evolutionary fingerprints of EMT in pancreatic cancers
Luigi Perelli, Li Zhang, Sarah Mangiameli, Andrew J. C. Russell, Francesca Giannese, Fuduan Peng, Federica Carbone, Courtney Le, Hania Khan, Francesca Citron, Melinda Soeung, Truong Nguyen Anh Lam, Sebastian Lundgren, Cihui Zhu, Desiree Catania, Ningping Feng, Enrico Gurreri, Alessandro Sgambato, Giampaolo Tortora, Giulio F. Draetta, Giovanni Tonon, Andrew Futreal, Virginia Giuliani, Alessandro Carugo, Andrea Viale, Timothy P. Heffernan, Linghua Wang, Davide Cittaro, Fei Chen, Giannicola Genovese

bioRxiv 2023.09.18.558231; doi: https://doi.org/10.1101/2023.09.18.558231 New Results

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Estradiol propionate reduction of nuclear size in prostate cancer lines lacking DHRS7 suggests DHRS7 absence as a biomarker for the effectiveness of estrogen therapy
Andrea Rizzotto, Sylvain Tollis, Nhan T. Pham, Yijing Zheng, Maria Alba Abad, Jan Wildenhain, A. Arockia Jeyaprakash, Manfred Auer, Mike Tyers, Eric C. Schirmer

bioRxiv 2023.09.18.558190; doi: https://doi.org/10.1101/2023.09.18.558190 New Results

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Cancer Biology

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