Cancer Biology

Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1 positive pediatric leukemia identifies drug-targetable transcription factor activities
Juha Mehtonen, Susanna Teppo, Mari Lahnalampi, Aleksi Kokko, Riina Kaukonen, Laura Oksa, Maria Bouvy-Liivrand, Alena Malyukova, Saara Laukkanen, Petri I. Mäkinen, Samuli Rounioja, Pekka Ruusuvuori, Olle Sangfelt, Riikka Lund, Tapio Lönnberg, Olli Lohi, Merja Heinäniemi

bioRxiv 2020.05.27.116293; doi: https://doi.org/10.1101/2020.05.27.116293 New Results

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Androgen signaling connects short isoform production to breakpoint formation at Ewing sarcoma breakpoint region 1 via an R-loop-dependent mechanism
Taylor R. Nicholas, Peter C. Hollenhorst

bioRxiv 2020.03.25.008391; doi: https://doi.org/10.1101/2020.03.25.008391 New Results

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Selective Labeling and Identification of the Tumor Cell Proteome of Pancreatic Cancer In Vivo
Nancy G. Azizian, Litong Nie, Delaney K. Sullivan, Sammy Pardo, Dana Molleur, Junjie Chen, Susan T. Weintraub, Yulin Li

bioRxiv 2020.05.25.113670; doi: https://doi.org/10.1101/2020.05.25.113670 New Results

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Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia
Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Lev M. Kats, Carolyn Shembrey, Thomas C. Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew H. Wei, Gareth P. Gregory, Stephin J. Vervoort, Kristin K. Brown, Ricky W. Johnstone

bioRxiv 2020.05.26.116392; doi: https://doi.org/10.1101/2020.05.26.116392 New Results

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Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities
Jason H. Rogers, Rohit Gupta, Jaime M. Reyes, Michael C. Gundry, Geraldo Medrano, Anna Guzman, Tidie Song, Cade Johnson, Sean Barnes, Carlo D. D. Cristobal, Lorenzo Brunetti, Margaret A. Goodell, Rachel E. Rau

bioRxiv 2020.05.26.109579; doi: https://doi.org/10.1101/2020.05.26.109579 New Results

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“Temporal control of tumor growth in nocturnal mammals: impact of the circadian system”
Paula M. Wagner, César G. Prucca, Fabiola N. Velázquez, Lucas Sosa Alderete, Beatriz L. Caputto, Mario E. Guido

bioRxiv 2020.05.25.114652; doi: https://doi.org/10.1101/2020.05.25.114652 New Results

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A screen of FDA-approved drugs identifies inhibitors of Protein Tyrosine Phosphatase 4A3 (PTP4A3 or PRL-3)
Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn

bioRxiv 2020.05.24.098665; doi: https://doi.org/10.1101/2020.05.24.098665 New Results

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Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation
Chee Kin Then, Salome Paillas, Xuedan Wang, Alix Hampson, Anne E Kiltie

bioRxiv 846436; doi: https://doi.org/10.1101/846436 New Results

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Hypoxia-induced SETX links replication stress with the unfolded protein response
Shaliny Ramachandran, Tiffany Ma, Natalie Ng, Iosifina P. Foskolou, Ming-Shih Hwang, Pedro Victori, Wei-Chen Cheng, Francesca M. Buffa, Katarzyna B. Leszczynska, Natalia Gromak, Ester M. Hammond

bioRxiv 2020.05.24.113548; doi: https://doi.org/10.1101/2020.05.24.113548 New Results

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DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC
Divya Reddy, Saikat Bhattacharya, Sanket Shah, Mudasir Rashid, Sanjay Gupta

bioRxiv 2020.05.23.112516; doi: https://doi.org/10.1101/2020.05.23.112516 New Results

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Cancer Biology

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