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Cancer Biology

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  • ModulOmics: Integrating Multi-Omics Data to Identify Cancer Driver Modules
    Dana Silverbush, Simona Cristea, Gali Yanovich, Tamar Geiger, Niko Beerenwinkel, Roded Sharan
    bioRxiv 288399; doi: https://doi.org/10.1101/288399 New Results
  • Altered function of the glutamate aspartate transporter GLAST in glioblastoma
    Serena Pellegatta, Cristina Corbetta, Natalia Di Ianna, Maria Grazia Bruzzone, Monica Patanè, Bianca Pollo, Gabriele Cantini, Manuela Cominelli, Ileana Zucca, Federica Pisati, Pietro Luigi Poliani, Gaetano Finocchiaro
    bioRxiv 287623; doi: https://doi.org/10.1101/287623 New Results
  • The Origins and Consequences of Localized and Global Somatic Hypermutation
    Fouad Yousif, Stephenie Prokopec, Ren X Sun, Fan Fan, Christopher M Lalansingh, David H Park, Lesia Szyca, PCAWG Network, Paul C Boutros
    bioRxiv 287839; doi: https://doi.org/10.1101/287839 New Results
  • A chemoproteomic portrait of the oncometabolite fumarate
    Rhushikesh A Kulkarni, Daniel W Bak, Darmood Wei, Sarah E Bergholtz, Chloe A Briney, Jonathan H Shrimp, Abigail L Thorpe, Arissa Bavari, Aktan Alpsoy, Michaella Levy, Laurence Florens, Michael P Washburn, Emily C Dykhuizen, Norma Frizzell, Eranthie Weerapana, W. Marston Linehan, Jordan L Meier
    bioRxiv 285759; doi: https://doi.org/10.1101/285759 New Results
  • Preclinical Study: Sunitinib-suppressed MiR-452-5p Facilitates Renal Cancer Cell Invasion and Metastasis Through Modulating SMAD4/SMAD7/EMT Signals
    Wei Zhai, Saiyang Li, Jin Zhang, Yonghui Chen, Junjie Ma, Wen Kong, Dongkui Gong, Junhua Zheng, Wei Xue, Yunfei Xu
    bioRxiv 286898; doi: https://doi.org/10.1101/286898 New Results
  • Dynamics of human protein kinases linked to drug selectivity
    Dorothee Kern, Warintra Pitsawong, Vanessa Buosi, Renee Otten, Roman V Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo AP Pádua, Xavier Meniche
    bioRxiv 286310; doi: https://doi.org/10.1101/286310 New Results
  • Plk1 overexpression suppresses tumor development by inducing chromosomal instability
    Guillermo de Carcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montanes, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres, Rocio Sotillo
    bioRxiv 285635; doi: https://doi.org/10.1101/285635 New Results
  • Recapitulation of human germline coding variation in an ultra-mutated infant leukemia
    Alexander M Gout, Rishi S Kotecha, Parwinder Kaur, Ana Abad, Bree Foley, Kim W Carter, Catherine H Cole, Charles S Bond, Ursula R Kees, Jason Waithman, Mark N Cruickshank
    bioRxiv 248690; doi: https://doi.org/10.1101/248690 New Results
  • HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells
    Hannah Harrison, Henry J Pegg, Jamie Thompson, Christian Bates, Paul Shore
    bioRxiv 266213; doi: https://doi.org/10.1101/266213 New Results
  • YES1 amplification: a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
    Pang-Dian Fan, Giuseppe Narzisi, Anitha D Jayaprakash, Elisa Venturini, Nicolas Robine, Peter Smibert, Soren Germer, Helena A Yu, Emmet J Jordan, Paul K Paik, Yelena Y Janjigian, Jamie E Chaft, Lu Wang, Achim A Jungbluth, Sumit Middha, Lee Spraggon, Huan Qiao, Christine M Lovly, Mark G Kris, Gregory J Riely, Katerina Politi, Harold Varmus, Marc Ladanyi
    bioRxiv 275974; doi: https://doi.org/10.1101/275974 New Results

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