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Cancer Biology

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  • Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use
    Margs S. Brennan, Catherine Chang, Grant Dewson, Lin Tai, Guillaume Lessene, Andreas Strasser, Gemma L. Kelly, Marco J. Herold
    bioRxiv 335430; doi: https://doi.org/10.1101/335430
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  • Distinct Microbes, Metabolites, and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers
    Vanessa L. Hale, Patricio Jeraldo, Jun Chen, Michael Mundy, Janet Yao, Sambhawa Priya, Gary Keeney, Kelly Lyke, Jason Ridlon, Bryan A. White, Amy J. French, Stephen N. Thibodeau, Christian Diener, Osbaldo Resendis-Antonio, Jaime Gransee, Tumpa Dutta, Xuan-Mai Petterson, Ran Blekhman, Lisa Boardman, David Larson, Heidi Nelson, Nicholas Chia
    bioRxiv 346510; doi: https://doi.org/10.1101/346510
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  • Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia
    Hussain Mubarak Al-Aamri, Heng Ku, Helen R Irving, Joseph Tucci, Terri Meehan-Andrews, Christopher Bradley
    bioRxiv 346031; doi: https://doi.org/10.1101/346031
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  • O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer
    Nikita S Sharma, Vineet K Gupta, Patricia Dauer, Kousik Kesh, Roey Hadad, Bhuwan Giri, Anjali Chandra, Vikas Dudeja, Chad Slawson, Santanu Banerjee, Selwyn M Vickers, Ashok Saluja, Sulagna Banerjee
    bioRxiv 345223; doi: https://doi.org/10.1101/345223
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  • Modelling the nuclear envelope of HeLa cells
    Cefa Karabağ, Martin L. Jones, Christopher J. Peddie, Anne E. Weston, Lucy M. Collinson, Constantino Carlos Reyes-Aldasoro
    bioRxiv 344986; doi: https://doi.org/10.1101/344986
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  • Distinct oncogenes drive distinct genome and epigenome alterations in human mammary epithelial cells
    Claire Fonti, Anne Saumet, Amanda Abi-Khalil, Béatrice Orsetti, William Jacot, Elouan Cleroux, Ambre Bender, Michael Dumas, Emeline Schmitt, Jacques Colinge, Michael Weber, Claude Sardet, Stanislas du Manoir, Charles Theillet
    bioRxiv 344465; doi: https://doi.org/10.1101/344465
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  • The systemic activin response to pancreatic cancer: Implications for effective cancer cachexia therapy
    Xiaoling Zhong, Marianne Pons, Christophe Poirier, Yanlin Jiang, Jianguo Liu, George E. Sandusky, Yunlong Liu, Guanglong Jiang, Marion Couch, Leonidas G. Koniaris, Teresa A. Zimmers
    bioRxiv 343871; doi: https://doi.org/10.1101/343871
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  • Lysyl oxidase inhibition drives the transdifferentiation from lung adenocarcinoma to squamous cell carcinoma in mice
    Shun Yao, Xiangkun Han, Xinyuan Tong, Fuming Li, Zhen Qin, Hsin-Yi Huang, Ji Hongbin
    bioRxiv 314393; doi: https://doi.org/10.1101/314393
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  • Novel Significant Stage-Specific Differentially Expressed Genes in Liver Hepatocellular Carcinoma
    Arjun Sarathi, Ashok Palaniappan
    bioRxiv 342204; doi: https://doi.org/10.1101/342204
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  • Modulation of mutant KrasG12D-driven lung tumorigenesis in vivo by gain or loss of PCDH7 function
    Xiaorong Zhou, Bret M. Evers, Mahesh S. Padanad, James A. Richardson, Emily Stein, Jingfei Zhu, Robert E. Hammer, Kathryn A. O’Donnell
    bioRxiv 343103; doi: https://doi.org/10.1101/343103
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