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Cancer Biology

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  • Motif Disruption Domains Lead To Cancer Gene Expression Rewiring
    Fabien C. Lamaze, Aurelien Chateigner, Hilary A. Edgington, Marie-Julie Fave, Armande Ang Houle, PCAWG3, Philip Awadalla
    bioRxiv 126359; doi: https://doi.org/10.1101/126359
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  • Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays
    Daniel J. Urban, Natalia J. Martinez, Mindy I. Davis, Kyle R. Brimacombe, Dorian M. Cheff, Tobie D. Lee, Mark J. Henderson, Steven A. Titus, Rajan Pragani, Jason M. Rohde, Yuhong Wang, Surendra Karavadhi, Pranav Shah, Olivia W. Lee, Amy Wang, Andrew McIver, Hongchao Zheng, Xiaodong Wang, Xin Xu, Ajit Jadhav, Anton Simeonov, Min Shen, Matthew B. Boxer, Matthew D. Hall
    bioRxiv 124024; doi: https://doi.org/10.1101/124024
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  • Resolving drug effects in patient-derived cancer cells links organoid responses to genome alterations
    Julia Neugebauer, Franziska M. Zickgraf, Jeongbin Park, Steve Wagner, Xiaoqi Jiang, Katharina Jechow, Kortine Kleinheinz, Umut H. Toprak, Marc A. Schneider, Michael Meister, Saskia Spaich, Marc Sütterlin, Matthias Schlesner, Andreas Trumpp, Martin Sprick, Roland Eils, Christian Conrad
    bioRxiv 124446; doi: https://doi.org/10.1101/124446
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  • APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response
    Alexander P. Glaser, Damiano Fantini, Kalen J. Rimar, Joshua J. Meeks
    bioRxiv 123802; doi: https://doi.org/10.1101/123802
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  • LncRNA-TUG1/EZH2 axis promotes cell proliferation, migration and the EMT phenotype formation through sponging miR-382
    Liang Zhao, Hongwei Sun, Hongru Kong, Zongjing Chen, Bicheng Chen, Mengtao Zhou
    bioRxiv 123141; doi: https://doi.org/10.1101/123141
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  • EMT and MET: necessary or permissive for metastasis?
    Mohit Kumar Jolly, Kathryn E Ware, Shivee Gilja, Jason A Somarelli, Herbert Levine
    bioRxiv 122051; doi: https://doi.org/10.1101/122051
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  • Epithelial-mesenchymal plasticity: How have quantitative mathematical models helped improve our understanding?
    Mohit Kumar Jolly, Satyendra C Tripathi, Jason A Somarelli, Samir M Hanash, Herbert Levine
    bioRxiv 122036; doi: https://doi.org/10.1101/122036
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  • DNA-dependent protein synthesis exhibited by cancer shed particulates
    Vijay K. Ulaganathan, Axel Ullrich
    bioRxiv 121186; doi: https://doi.org/10.1101/121186
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  • Exome-capture RNA-sequencing of decade-old breast cancers and matched decalcified bone metastases identifies clinically actionable targets
    Nolan Priedigkeit, Rebecca J. Watters, Peter C. Lucas, Ahmed Basudan, Rohit Bhargava, William Horne, Jay K. Kolls, Zhou Fang, Margaret Q. Rosenzweig, Adam M. Brufsky, Kurt R. Weiss, Steffi Oesterreich, Adrian V. Lee
    bioRxiv 120709; doi: https://doi.org/10.1101/120709
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  • Selectivity profile of the poly(ADP-ribose) polymerase (PARP) inhibitor, A-966492
    Ann-Gerd Thorsell, Herwig Schüler
    bioRxiv 119818; doi: https://doi.org/10.1101/119818
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