Cancer Biology

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer
Shunfei Yan, Piyush B. Madhamshettiwar, Kaylene J. Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E. Sheppard, Katherine M. Hannan, Ross D. Hannan, Elaine Sanij, Richard B. Pearson, Keefe T. Chan

bioRxiv 849307; doi: https://doi.org/10.1101/849307 New Results

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Generation of novel diagnostic and therapeutic exosomes to detect and deplete pro-tumorigenic M2-macrophages
Mohammad Harun Rashid, Thaiz F. Borin, Roxan Ara, Ahmet Alptekin, Yutao Liu, Ali S. Arbab

bioRxiv 849448; doi: https://doi.org/10.1101/849448 New Results

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Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis
E. P. Kusnadi, A. S. Trigos, C. Cullinane, D. L. Goode, O. Larsson, J. R. Devlin, K. T. Chan, D. P. De Souza, M. J. McConville, G. A. McArthur, G. Thomas, E. Sanij, G. Poortinga, R. D. Hannan, K. M. Hannan, J. Kang, R. B. Pearson

bioRxiv 847723; doi: https://doi.org/10.1101/847723 New Results

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Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron C. Hann, Marina Sirota, Arun P. Wiita

bioRxiv 847368; doi: https://doi.org/10.1101/847368 New Results

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Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs
Martin Golkowski, Ho-Tak Lau, Marina Chan, Heidi Kenerson, Venkata Narayana Vidadala, Anna Shoemaker, Dustin J. Maly, Raymond S. Yeung, Taranjit S. Gujral, Shao-En Ong

bioRxiv 849281; doi: https://doi.org/10.1101/849281 New Results

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Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz, Andrew Dhawan, Daria Myroshnychenko, Diego Lozano-Peral, Bina Desai, Olena Balynska, Jan Poleszhuk, Liu Kenian, Mohamed Abazeed, Omar Mian, Aik Choon Tan, Eric Haura, Jacob Scott, Andriy Marusyk

bioRxiv 504837; doi: https://doi.org/10.1101/504837 New Results

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A genetic map of the response to DNA damage in human cells
Michele Olivieri, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, Matthew J. Schellenberg, Michal Zimmermann, Nicole Hustedt, Silvia Emma Rossi, Salomé Adam, Henrique Melo, Anne Margriet Heijink, Guillermo Sastre-Moreno, Nathalie Moatti, Rachel Szilard, Andrea McEwan, Alexanda K. Ling, Almudena Serrano-Benitez, Tajinder Ubhi, Irene Delgado-Sainz, Michael W. Ferguson, Grant W. Brown, Felipe Cortés-Ledesma, R. Scott Williams, Alberto Martin, Dongyi Xu, Daniel Durocher

bioRxiv 845446; doi: https://doi.org/10.1101/845446 New Results

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The gut microbiota may drive the radiosensitising effect of a high fibre diet
Chee Kin Then, Salome Paillas, Alix Hampson, Anne E Kiltie

bioRxiv 846436; doi: https://doi.org/10.1101/846436 New Results

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Therapeutic efficacy of an immune stimulatory gene therapy strategy in a mouse model of high grade brainstem glioma
Flor M. Mendez, Padma Kadiyala, Felipe J. Nunez, Stephen Carney, Fernando Nunez, Jessica C. Gauss, Ramya Ravindran, Sheeba Pawar, Marta Edwards, Pedro R. Lowenstein, Maria G. Castro

bioRxiv 846097; doi: https://doi.org/10.1101/846097 New Results

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Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers
Guillaume Vares, Vincent Jallet, Yoshitaka Matsumoto, Cedric Rentier, Kentaro Takayama, Toshio Sasaki, Yoshio Hayashi, Hiroaki Kumada, Hirotaka Sugawara

bioRxiv 471128; doi: https://doi.org/10.1101/471128 New Results

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Cancer Biology

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