Cancer Biology

Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by sequential intermittent anti-PI3Kα/β/δ and anti-PD-1 treatment
Zhi Qi, Zihan Xu, Liuzhen Zhang, Yongkang Zou, Wenyu Yan, Cheng Li, Ningshu Liu, Hong Wu

bioRxiv 2020.10.17.343608; doi: https://doi.org/10.1101/2020.10.17.343608 New Results

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Loss of MGA mediated Polycomb repression promotes tumor progression and invasiveness
Haritha Mathsyaraja, Jonathen Catchpole, Emily Eastwood, Ekaterina Babaeva, Michael Geuenich, Pei Feng Cheng, Brian Freie, Jessica Ayers, Ming Yu, Nan Wu, Kumud R Poudel, Amanda Koehne, William Grady, A McGarry Houghton, Yuzuru Shiio, David P MacPherson, Robert N Eisenman

bioRxiv 2020.10.16.334714; doi: https://doi.org/10.1101/2020.10.16.334714 New Results

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Understanding the potential benefits of adaptive therapy for metastatic melanoma
Eunjung Kim, Joel S. Brown, Zeynep Eroglu, Alexander R.A. Anderson

bioRxiv 2020.10.16.343269; doi: https://doi.org/10.1101/2020.10.16.343269 New Results

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Run for your life – an integrated virtual tissue platform for incorporating exercise oncology into immunotherapy
Josua Aponte Serrano, Amit Hagar

bioRxiv 2020.09.04.283416; doi: https://doi.org/10.1101/2020.09.04.283416 New Results

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The Oncogenic Function of PLAGL2 is Mediated via Specific Target Genes Through a Wnt-independent Mechanism in Colorectal Cancer
Anthony D. Fischer, Daniel A. Veronese-Paniagua, Shriya Swaminathan, Hajime Kashima, Deborah C. Rubin, Blair B. Madison

bioRxiv 2020.10.14.339531; doi: https://doi.org/10.1101/2020.10.14.339531 New Results

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Quantifying the Influence of Mutation Detection on Tumour Subclonal Reconstruction
Lydia Y. Liu, Vinayak Bhandari, Adriana Salcedo, Shadrielle M. G. Espiritu, Quaid D. Morris, Thomas Kislinger, Paul C. Boutros

bioRxiv 418780; doi: https://doi.org/10.1101/418780 New Results

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A pan-cancer metabolic atlas of the tumor microenvironment
Neha Rohatgi, Umesh Ghoshdastider, Probhonjon Baruah, Anders Jacobsen Skanderup

bioRxiv 2020.10.16.342519; doi: https://doi.org/10.1101/2020.10.16.342519 New Results

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High dimensional immunotyping of the obese tumor microenvironment reveals model specific adaptation
Cara E Wogsland, Hilde E Lien, Line Pedersen, Pahul Hanjra, Sturla M Grondal, Rolf A Brekken, James B Lorens, Nils Halberg

bioRxiv 2020.10.14.338806; doi: https://doi.org/10.1101/2020.10.14.338806 New Results

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Microbiome signatures in a fast and slow progressing gastric cancer murine model and their contribution to gastric carcinogenesis
Prerna Bali, Joanna Coker, Ivonne Lozano-Pope, Karsten Zengler, Marygorret Obonyo

bioRxiv 2020.10.15.341701; doi: https://doi.org/10.1101/2020.10.15.341701 New Results

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Sequential Measurements of Catalytic Activities of Multi-Drug-Resistance Transporters and Cytochrome P450 Enzymes by Cytometry of Reaction Rate Constant
Vasilij Koshkin, Mariana Bleker de Oliveira, Sven Kochmann, Chun Peng, Sergey N. Krylov

bioRxiv 2020.10.15.340976; doi: https://doi.org/10.1101/2020.10.15.340976 New Results

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Cancer Biology

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