Cell Biology

Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk
PR Goody, D Christmann, D Goody, D Nehl, K Becker, K Wilhelm-Jüngling, S Uchida, JB Moore IV, S Zimmer, F Bakhtiary, A Pfeifer, E Latz, G Nickenig, F Jansen, MR Hosen

bioRxiv 2022.11.29.518326; doi: https://doi.org/10.1101/2022.11.29.518326 New Results

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The human sperm head spins with a conserved direction during swimming in 3D
G. Corkidi, F. Montoya, A.L. González-Cota, P. Hernández-Herrera, N.C. Bruce, H. Bloomfield-Gadêlha, A. Darszon

bioRxiv 2022.11.28.517870; doi: https://doi.org/10.1101/2022.11.28.517870 New Results

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Utilization of an Artery-on-a-chip to unravel novel regulators and therapeutic targets in vascular diseases
Valentina Paloschi, Jessica Pauli, Greg Winski, Zhiyuan Wu, Zhaolong Li, Nadiya Glukha, Nora Hummel, Felix Rogowitz, Sandro Meucci, Lorenzo Botti, Albert Busch, Ekaterina Chernogubova, Hong Jin, Nadja Sachs, Hans-Henning Eckstein, Reinier A. Boon, Andreas R. Bausch, Lars Maegdefessel

bioRxiv 2022.11.29.517312; doi: https://doi.org/10.1101/2022.11.29.517312 New Results

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Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway
Iqbal Dulloo, Michael Tellier, Clémence Levet, Anissa Chikh, Boyan Zhang, Catherine M Webb, David P Kelsell, Matthew Freeman

bioRxiv 2022.11.28.518246; doi: https://doi.org/10.1101/2022.11.28.518246 New Results

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Human Gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signaling in budding yeast
Marta Valenti, María Molina, Víctor J Cid

bioRxiv 2022.11.29.518328; doi: https://doi.org/10.1101/2022.11.29.518328 New Results

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Characterisation of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
Caroline Frørup, Rebekka Gerwig, Cecilie Amalie Søndergaard Svane, Joana Mendes Lopes de Melo, Tina Fløyel, Flemming Pociot, Simranjeet Kaur, Joachim Størling

bioRxiv 2022.11.29.518315; doi: https://doi.org/10.1101/2022.11.29.518315 New Results

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The direct interaction with transcriptional factor TEAD4 implied a straightforward regulation mechanism of tumor suppressor NF2
Liqiao Hu, Mengying Wu, Lingli He, Liang Yuan, Lingling Yang, Bin Zhao, Lei Zhang, Xiaojing He

bioRxiv 2022.11.28.518166; doi: https://doi.org/10.1101/2022.11.28.518166 New Results

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PTPN1 deficiency modulates BMPR2 signaling and induces endothelial dysfunction in Pulmonary Arterial Hypertension
Md Khadem Ali, Xuefei Tian, Lan Zhao, Katharina Schimmel, Christopher J. Rhodes, Martin R. Wilkins, Mark R. Nicolls, Edda F. Spiekerkoetter

bioRxiv 2022.11.27.518092; doi: https://doi.org/10.1101/2022.11.27.518092 New Results

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Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
Sevim Kahraman, Kimitaka Shibue, Dario F. De Jesus, Jiang Hu, Debasish Manna, Bridget K. Wagner, Amit Choudhary, Rohit N. Kulkarni

bioRxiv 2022.11.27.518097; doi: https://doi.org/10.1101/2022.11.27.518097 New Results

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A lysosomal lipid transport pathway that enables cell survival under choline limitation
Samantha G. Scharenberg, Wentao Dong, Kwamina Nyame, Roni Levin-Konigsberg, Aswini R. Krishnan, Eshaan S. Rawat, Kaitlyn Spees, Michael C. Bassik, Monther Abu-Remaileh

bioRxiv 2022.11.27.517422; doi: https://doi.org/10.1101/2022.11.27.517422 New Results

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Cell Biology

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