Clinical Trials

Targeting regulatory T cells with Interleukin-2 treatment in type 1 diabetes: a response-adaptive, non-randomised, open-label trial of repeat doses of Aldesleukin (DILfrequency)
Eleonora Seelig, James Howlett, Linsey Porter, Lucy Truman, James Heywood, Jane Kennet, Emma L Arbon, Katerina Anselmiova, Neil M. Walker, Ravinder Atkar, Marcin L Pekaiski, Ed Rytina, Mark Evans, Linda S. Wicker, John A. Todd, Adrian P. Mander, Simon Bond, Frank Waldron-Lynch

bioRxiv 223958; doi: https://doi.org/10.1101/223958

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Effect of vitamin D supplementation on biomarkers of inflammation and immune function: functional genomics analysis of the BEST-D trial
Antonio J. Berlanga-Taylor, Katherine Plant, Andrew Dahl, Evelyn Lau, Michael Hill, David Sims, Andreas Heger, Jonathan Emberson, Jane Armitage, Robert Clarke, Julian C. Knight

bioRxiv 217612; doi: https://doi.org/10.1101/217612

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Influence of APOA5 locus on the treatment efficacy of three statins: evidence from a randomized pilot study in Chinese subjects
Sha Hua, Chuanxiang Ma, Jun Zhang, Jing Li, Weiwei Wu, Ning Xu, Guanghua Luo, Jianrong Zhao

bioRxiv 213629; doi: https://doi.org/10.1101/213629

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The NSIGHT1 Randomized Controlled Trial: Rapid Whole Genome Sequencing for Accelerated Etiologic Diagnosis in Critically Ill Infants
Josh E. Petrikin, Julie A. Cakici, Michelle M. Clark, Laurel K. Willig, Nathaly M. Sweeney, Emily G. Farrow, Carol J. Saunders, Isabelle Thiffault, Neil A. Miller, Lee Zellmer, Suzanne M. Herd, Anne M. Holmes, Serge Batalov, Narayanana Veeraraghavan, Laurie D. Smith, David P. Dimmock, Steven J. Leeder, Stephen F. Kingsmore

bioRxiv 218255; doi: https://doi.org/10.1101/218255

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A Pilot Randomized Trial of Oral Magnesium Supplementation on Supraventricular Arrhythmias
Pamela L. Lutsey, Lin Y. Chen, Anne Eaton, Melanie Jaeb, Kyle D. Rudser, James D. Neaton, Alvaro Alonso

bioRxiv 215319; doi: https://doi.org/10.1101/215319

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An interventional Soylent diet increases the Bacteroidetes to Firmicutes ratio in human gut microbiome communities: a randomized controlled trial
Ryan H. Hsu, Dylan M. McCormick, Mitchell J. Seitz Jr., Lauren M. Lui, Harneet S. Rishi, Adam P. Arkin

bioRxiv 200881; doi: https://doi.org/10.1101/200881

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A randomized placebo-controlled trial on the antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression
Fernanda Palhano-Fontes, Dayanna Barreto, Heloisa Onias, Katia C Andrade, Morgana Novaes, Jessica A Pessoa, Sergio A Mota-Rolim, Flavia Osório, Rafael Sanches, Rafael G dos Santos, Luís F Tófoli, Gabriela de Oliveira Silveira, Mauricio Yonamine, Jordi Riba, Francisco RR Santos, Antonio A Silva-Junior, João Alchieri, Nicole L Galvão-Coelho, Bruno Lobão-Soares, Jaime Hallak, Emerson Arcoverde, João P Maia-de-Oliveira, Draulio B Araújo

bioRxiv 103531; doi: https://doi.org/10.1101/103531

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Protection of the human gut microbiome from antibiotics
Jean de Gunzburg, Amine Ghozlane, Annie Ducher, Emmanuelle Le Chatelier, Xavier Duval, Etienne Ruppé, Laurence Armand-Lefevre, Frédérique Sablier-Gallis, Charles Burdet, Loubna Alavoine, Elisabeth Chachaty, Violaine Augustin, Marina Varastet, Florence Levenez, Sean Kennedy, Nicolas Pons, France Mentré, Antoine Andremont

bioRxiv 169813; doi: https://doi.org/10.1101/169813

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Topical Silver Diamine Fluoride for Dental Caries Arrest in Preschool Children: A Randomized Controlled Trial
Peter Milgrom, Jeremy A. Horst, Sharity Ludwig, Marilynn Rothen, Benjamin W. Chaffee, Svetlana Lyalina, Katherine S. Pollard, Joseph L. DeRisi, Lloyd Mancl

bioRxiv 131870; doi: https://doi.org/10.1101/131870

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A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML
Lia Gore, Timothy J. Triche Jr., Jason E. Farrar, Daniel Wai, Christophe Legendre, Gerald C Gooden, Winnie S. Liang, John Carpten, David Lee, Frank Alvaro, Margaret E. Macy, Carola Arndt, Philip Barnette, Todd Cooper, Laura Martin, Aru Narendran, Jessica Pollard, Soheil Meshinchi, Jessica Boklan, Robert J Arceci, Bodour Salhia

bioRxiv 124263; doi: https://doi.org/10.1101/124263

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Clinical Trials

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