Genetics

Multiplex genetic engineering exploiting pyrimidine salvage pathway-based self-encoded selectable markers
Lukas Birstonas, Alex Dallemulle, Manuel S Lopez-Berges, Ilse D Jacobsen, Martin Offterdinger, Beate Abt, Maria Strassburger, Ingo Bauer, Oliver Schmidt, Bettina Sarg, Herbert Lindner, Hubertus Haas, Fabio Gsaller

bioRxiv 2020.01.16.908764; doi: https://doi.org/10.1101/2020.01.16.908764 New Results

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Amelioration of Brain Histone Methylopathies by Balancing a Writer-Eraser Duo KMT2A-KDM5C
Christina N Vallianatos, Brynne Raines, Robert S Porter, Katherine M Bonefas, Michael C Wu, Patricia M Garay, Katie M Collette, Young Ah Seo, Yali Dou, Catherine E Keegan, Natalie Tronson, Shigeki Iwase

bioRxiv 567917; doi: https://doi.org/10.1101/567917 New Results

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Studies of human twins reveal genetic variation that affects dietary fat perception
Cailu Lin, Lauren Colquitt, Paul Wise, Paul Breslin, Nancy E Rawson, Federica Genovese, Ivy Maina, Paule Joseph, Lydia Fomuso, Louise Slade, Dennis Brooks, Aurelie Miclo, John Hayes, Antonio Sullo, Danielle R. Reed

bioRxiv 2020.01.18.910448; doi: https://doi.org/10.1101/2020.01.18.910448 New Results

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Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations
Ming-Huei Chen, Laura M. Raffield, Abdou Mousas, Blood-Cell Consortium (BCX2), Andrew D Johnson, Alexander P. Reiner, Paul Auer, Guillaume Lettre

bioRxiv 2020.01.17.910497; doi: https://doi.org/10.1101/2020.01.17.910497 New Results

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Non-essential function of KRAB zinc finger gene clusters in retrotransposon suppression
Gernot Wolf, Alberto de Iaco, Ming-An Sun, Melania Bruno, Matthew Tinkham, Don Hoang, Apratim Mitra, Shery Ralls, Didier Trono, Todd Macfarlan

bioRxiv 2020.01.17.910679; doi: https://doi.org/10.1101/2020.01.17.910679 New Results

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Cell signaling coordinates global Polycomb Repressive Complex 2 recruitment and gene expression in murine embryonic stem cells
Mohammad B Aljazi, Yuen Gao, Yan Wu, George I. Mias, Jin He

bioRxiv 597674; doi: https://doi.org/10.1101/597674 New Results

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Characterisation of the genetic architecture of immune-mediated disease through informed dimension reduction
Oliver S Burren, Guillermo Reales, Limy Wong, John Bowes, James C Lee, Anne Barton, Paul A Lyons, Kenneth GC Smith, Wendy Thomson, Paul DW Kirk, Chris Wallace

bioRxiv 2020.01.14.905869; doi: https://doi.org/10.1101/2020.01.14.905869 New Results

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Towards an information theory of quantitative genetics
David J Galas, James M Kunert-Graf, Lisa Uechi, Nikita A Sakhanenko

bioRxiv 811950; doi: https://doi.org/10.1101/811950 New Results

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Resolving mechanisms of immune-mediated disease in primary CD4 T cells
Christophe Bourges, Abigail F Groff, Oliver S Burren, Chiara Gerhardinger, Kaia Mattioli, Anna Hutchinson, Theodore Hu, Tanmay Anand, Madeline W Epping, Chris Wallace, Kenneth G. C. Smith, John Rinn, James C Lee

bioRxiv 2020.01.16.908988; doi: https://doi.org/10.1101/2020.01.16.908988 New Results

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Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposure
Vincent Laville, Timothy Majarian, Yun J Sung, Karen Schwander, Mary F Feitosa, Daniel Chasman, Amy R Bentley, Charles N Rotimi, L Adrienne Cupples, Paul S de Vries, Michael R Brown, Alanna C Morrison, Aldi T Kraja, Mike Province, C. Charles Gu, James Gauderman, DC Rao, Alisa Manning, Hugues Aschard, on behalf of the CHARGE Gene-Lifestyle Interactions Working Group

bioRxiv 562157; doi: https://doi.org/10.1101/562157 New Results

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Genetics

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