Genetics

Clonal heterogeneity influences the fate of new adaptive mutations
Ignacio Vázquez-García, Francisco Salinas, Jing Li, Andrej Fischer, Benjamin Barré, Johan Hallin, Anders Bergström, Elisa Alonso-Perez, Jonas Warringer, Ville Mustonen, Gianni Liti

bioRxiv 039859; doi: https://doi.org/10.1101/039859 New Results
Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits
Farhad Hormozdiari, Steven Gazal, Bryce van de Geijn, Hilary Finucane, Chelsea J.-T. Ju, Po-Ru Loh, Armin Schoech, Yakir Reshef, Xuanyao Liu, Luke O'Connor, Alexander Gusev, Eleazar Eskin, Alkes Price

bioRxiv 203380; doi: https://doi.org/10.1101/203380 New Results
Polygenic risk scores applied to a single cohort reveal pleiotropy among hundreds of human phenotypes
Adam Socrates, Tom Bond, Ville Karhunen, Juha Auvinen, Cornelius Rietveld, Juha Veijola, Marjo-Riitta Jarvelin, Paul O'Reilly

bioRxiv 203257; doi: https://doi.org/10.1101/203257 New Results
6-OHDA-induced dopaminergic neurodegeneration in C. elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33
Sarah-Lena Offenburger, Xue Yan Ho, Theresa Tachie-Menson, Sean Coakley, Massimo A. Hilliard, Anton Gartner

bioRxiv 198606; doi: https://doi.org/10.1101/198606 New Results
Modified hCFTR mRNA restores normal lung function in a mouse model of cystic fibrosis
A. K. M. Ashiqul Haque, Alexander Dewerth, Justin S. Antony, Joachim Riethmüller, Ngadhnjim Latifi, Hanzey Yasar, Petra Weinmann, Nicoletta Pedemonte, Elvira Sondo, Julie Laval, Patrick Schlegel, Christian Seitz, Brigitta Loretz, Claus-Michael Lehr, Rupert Handgretinger, Michael S. D. Kormann

bioRxiv 202853; doi: https://doi.org/10.1101/202853 New Results
Mutations in C. elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment
Sarah-Lena Offenburger, Elisabeth Jongsma, Anton Gartner

bioRxiv 203067; doi: https://doi.org/10.1101/203067 New Results
Genomic Locus Modulating IOP in the BXD RI Mouse Strains
Rebecca A King, Ying Li, Jiaxing Wang, Felix Struebing, Eldon Geisert

bioRxiv 202937; doi: https://doi.org/10.1101/202937 New Results
Paleo-Eskimo genetic legacy across North America
Pavel Flegontov, Nefize Ezgi Altinisik, Piya Changmai, Nadin Rohland, Swapan Mallick, Deborah A. Bolnick, Francesca Candilio, Olga Flegontova, Choongwon Jeong, Thomas K. Harper, Denise Keating, Douglas J. Kennett, Alexander M. Kim, Thiseas C. Lamnidis, Inigo Olalde, Jennifer Raff, Robert A. Sattler, Pontus Skoglund, Edward J. Vajda, Sergey Vasilyev, Elizaveta Veselovskaya, M. Geoffrey Hayes, Dennis H. O'Rourke, Ron Pinhasi, Johannes Krause, David Reich, Stephan Schiffels

bioRxiv 203018; doi: https://doi.org/10.1101/203018 New Results
Modernized tools for streamlined genetic manipulation of wild and diverse symbiotic bacteria
Travis J. Wiles, Elena S. Wall, Brandon H. Schlomann, Edouard A. Hay, Raghuveer Parthasarathy, Karen Guillemin

bioRxiv 202861; doi: https://doi.org/10.1101/202861 New Results
Identification of genetic factors controlling domestication-related traits in cowpea (Vigna unguiculata L. Walp)
Sassoum Lo, Maria Munoz-Amatriain, Ousmane Boukar, Ira Herniter, Ndiaga Cisse, Yi-Ning Guo, Philip A. Roberts, Shizhong Xu, Christian Fatokun, Timothy J. Close

bioRxiv 202044; doi: https://doi.org/10.1101/202044 New Results

Genetics

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