Genetics

Generation of a Ym1 Deficient Mouse utilising CRISPR-Cas9 in CB6 Embryos
J E Parkinson, G E Baldwin, P H Papotto, N E Humphreys, A D Adamson, J E Allen, T E Sutherland

bioRxiv 2025.03.10.642405; doi: https://doi.org/10.1101/2025.03.10.642405 New Results

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Rapid emergence of hyperparasitic elements may stop P-element invasions in the absence of a piRNA-based host defence
Matthew Beaumont, Divya Selvaraju, Riccardo Pianezza, Robert Kofler

bioRxiv 2025.03.10.642342; doi: https://doi.org/10.1101/2025.03.10.642342 New Results

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A simulation-based deep learning framework for spatially explicit malaria modeling of CRISPR suppression gene drive mosquitoes
Yuan Hu Allegretti, Weitang Sun, Jackson Champer

bioRxiv 2025.03.10.642387; doi: https://doi.org/10.1101/2025.03.10.642387 New Results

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Integrating Natural and Engineered Genetic Variation to Decode Regulatory Influence on Blood Traits
Manuel Tardaguila, Dominique Von Schiller, Michela Colombo, Ilaria Gori, Eve L. Coomber, Thomas Vanderstichele, Paola Benaglio, Chiara Chiereghin, Sebastian Gerety, Dragana Vuckovic, Arianna Landini, Giuditta Clerici, Patrick Albers, Helen Ray-Jones, Katie L. Burnham, Alex Tokolyi, Elodie Persyn, Mikhail Spivakov, Vijay G. Sankaran, Klaudia Walter, Kousik Kundu, Nicola Pirastu, Michael Inouye, Dirk S. Paul, Emma E. Davenport, Pelin Sahlén, Stephen Watt, Nicole Soranzo

bioRxiv 2024.08.05.606572; doi: https://doi.org/10.1101/2024.08.05.606572 New Results

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Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing
Milan Malinsky, Marion Talbi, Chenxi Zhou, Nicholas Maurer, Samuel Sacco, Beth Shapiro, Catherine L. Peichel, Ole Seehausen, Walter Salzburger, Jesse N. Weber, Daniel I. Bolnick, Richard E. Green, Richard Durbin

bioRxiv 2025.03.06.641907; doi: https://doi.org/10.1101/2025.03.06.641907 New Results

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Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation
S. Sarafinovska, S.K. Koester, L.Z. Fang, J.W. Thorpe, S.M. Chaturvedi, J. Ji, E.F. Jones, D. Selmanovic, D.J. Kornbluth, M.R. Barrett, G.M. Rurak, S.E. Maloney, M.C. Creed, R.D. Mitra, J.D. Dougherty

bioRxiv 2025.03.10.642464; doi: https://doi.org/10.1101/2025.03.10.642464 New Results

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Phenotypic analysis of 11,125 trio exomes in neurodevelopmental disorders
Shiva Ganesan, Sarah M. Ruggiero, Shridhar Parthasarathy, Peter D. Galer, David Lewis-Smith, Ian McSalley, Stacey R. Cohen, Laina Lusk, Anna J. Prentice, Jillian L. McKee, Manuela Pendziwiat, Lacey Smith, Yvonne Weber, Heather C. Mefford, Annapurna Poduri, Ingo Helbig

bioRxiv 2025.03.11.642649; doi: https://doi.org/10.1101/2025.03.11.642649 New Results

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Massively parallel reporter assays identify functional enhancer variants at QT interval GWAS loci
Dongwon Lee, Lavanya Gunamalai, Jeerthi Kannan, Kyla Vickery, Or Yaacov, Ana C. Onuchic-Whitford, Aravinda Chakravarti, Ashish Kapoor

bioRxiv 2025.03.11.642686; doi: https://doi.org/10.1101/2025.03.11.642686 New Results

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Combinatorial effects of multiple genes contribute to beneficial aneuploidy phenotypes
M. Sophie Koller, Claudia Himmelbauer, Sarah Fink, Madhwesh C. Ravichandran, Christopher S. Campbell

bioRxiv 2025.03.05.641640; doi: https://doi.org/10.1101/2025.03.05.641640 New Results

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Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue
Yubao Cheng, Shengyuan Dang, Yuan Zhang, Yanbo Chen, Ruihuan Yu, Miao Liu, Shengyan Jin, Ailin Han, Samuel Katz, Siyuan Wang

bioRxiv 2025.03.06.641951; doi: https://doi.org/10.1101/2025.03.06.641951 New Results

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Genetics

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