Immunology

The macrophage reprogramming ability of antifolates reveals soluble CD14 as a potential biomarker for methotrexate response in rheumatoid arthritis
Sara Fuentelsaz-Romero, Celia Barrio Alonso, Raquel Garcia Campos, Monica Torres Torresano, Ittai Muller, Ana Triguero-Martinez, Laura Nuňo, Alejandro Villalba, Rosario García-Vicuña, Gerrit Jansen, Maria Eugenia Miranda-Carús, Isidoro González-Álvaro, Amaya Puig-Kröger

bioRxiv 2021.05.11.443581; doi: https://doi.org/10.1101/2021.05.11.443581 New Results

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Spatiotemporal single cell transcriptomic analyzis of human gut macrophages reveals multiple functional and niche-specific subsets
Diana Domanska, Umair Majid, Victoria Therese Karlsen, Marianne Aarstad Merok, Ann-Christin Beitnes, Sheraz Yaqub, Espen Sonderaal Bakkevold, Frode Lars Jahnsen

bioRxiv 2021.05.11.443586; doi: https://doi.org/10.1101/2021.05.11.443586 New Results

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Natural killer cell immunosuppressive function requires CXCR3-dependent redistribution within lymphoid tissues
Ayad Ali, Laura M Canaday, H Alex Feldman, Hilal Cevik, MIchael T Moran, Sanjeeth Rajaram, Nora Lakes, Jasmine A Tuazon, Harsha Seelamneni, Durga Kirshnamurthy, Eryn Blass, Dan H Barouch, Stephen Noel Waggoner

bioRxiv 2021.05.11.443590; doi: https://doi.org/10.1101/2021.05.11.443590 New Results

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A Non-redundant Role for T cell-derived IL-22 in Antibacterial Defense of Colonic Crypts
Casey T. Weaver, Carlene L. Zindl, Steven J. Witte, Vincent A. Laufer, Min Gao, Zongliang Yue, Daniel J. Silberger, Stacey N. Harbour, Jeffrey R. Singer, Duy Pham, Carson E. Moseley, Baiyi Cai, Henrietta Turner, Fran E. Lund, Bruce A. Vallance, Alexander F. Rosenberg, Jake Y. Chen, Robin D. Hatton

bioRxiv 2021.05.11.443677; doi: https://doi.org/10.1101/2021.05.11.443677 New Results

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Circulating CD138 (syndecan-1) enhances APRIL-mediated autoreactive B cell survival and differentiation in MRL/Lpr mice
Lunhua Liu, Mustafa Akkoyunlu

bioRxiv 2021.05.11.443667; doi: https://doi.org/10.1101/2021.05.11.443667 New Results

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Classical macrophage polarisation is limited by human β-defensin 3 via an autocrine IL-4 dependent process.
Maria E Candela, David J.P. Allsop, Roderick N Carter, Fiona Semple, Fiona Kilanowski, Sheila Webb, David Taggart, Henry J.W Mullan, Brian J McHugh, David H Dockrell, Donald J Davidson, Judith E Allen, Stephen J Jenkins, Nicholas M Morton, Julia R Dorin

bioRxiv 2021.05.06.442606; doi: https://doi.org/10.1101/2021.05.06.442606 New Results

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Precursor abundance influences divergent antigen specific CD8⁺ T cell responses after Yersinia pseudotuberculosis foodborne infection
Yue Zhang, Zhijuan Qiu, Brian Sheridan, James B. Bliska

bioRxiv 2021.05.10.443536; doi: https://doi.org/10.1101/2021.05.10.443536 New Results

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Design and immunogenicity of a Pan-SARS-CoV-2 synthetic DNA vaccine
Charles C Reed, Katherine Schultheis, Viviane M Andrade, Richa Kalia, Jared Tur, Blake Schouest, Dustin Elwood, Jewell N Walters, Igor Maricic, Arthur Doan, Miguel Vazquez, Zeena Eblimit, Patrick Pezzoli, Dinah Amante, Maria Yang, Joseph Fader, Roi Ferrer, David B Weiner, J Joseph Kim, Laurent M Humeau, Stephanie J Ramos, Trevor RF Smith, Kate E Broderick

bioRxiv 2021.05.11.443592; doi: https://doi.org/10.1101/2021.05.11.443592 New Results

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Concerns regarding vaccination as a management strategy against koala retrovirus
Briony A Joyce, Daniel Watterson, Ariel Isaacs, Keith Chappell

bioRxiv 2021.05.10.443397; doi: https://doi.org/10.1101/2021.05.10.443397 Contradictory Results

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Expanding the Potential Genes of Inborn Errors of Immunity through Protein Interactions
Humza A Khan, Manish J Butte

bioRxiv 2021.05.10.443508; doi: https://doi.org/10.1101/2021.05.10.443508 New Results

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Immunology

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