Immunology

Systemic sclerosis is a disease of a prematurely senescent, inflammatory and activated immunome
Bhairav Paleja, Andrea Low Hsiu Ling, Pavanish Kumar, Suzan Saidin, Ahmad Lajam, Sharifah Nur Hazirah, Camillus Chua, Lai Li Yun, Salvatore Albani

bioRxiv 637736; doi: https://doi.org/10.1101/637736 New Results
Integrated Metabolomic and Transcriptomic Profiling Reveals Novel Activation-Induced Metabolic Networks in Human T cells
S. Hiemer, S. Jatav, J. Jussif, J. Alley, S. Lathwal, M. Piotrowski, J. Janiszewski, R. Kibbey, T. Alves, D. Dumlao, A. Jha, H. Bandukwala

bioRxiv 635789; doi: https://doi.org/10.1101/635789 New Results
Immune Profiling Panel: a proof of concept study of a new multiplex molecular tool to assess the immune status of critically-ill patients
Dina M. Tawfik, Laurence Vachot, Adeline Bocquet, Fabienne Venet, Thomas Rimmelé, Guillaume Monneret, Sophie Blein, Jesse L. Montogomery, Andrew C. Hemmert, Alexandre Pachot, Virginie Moucadel, Javier Yugueros Marcos, Karen Brengel-Pesce, François Mallet, Julien Textoris

bioRxiv 636522; doi: https://doi.org/10.1101/636522 New Results
TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions
Tianqi Leng, Hossain Delowar Akther, Carl-Philipp Hackstein, Thomas King, Matthias Friedrich, Zoe Christoforidou, Sarah McCuaig, Mastura Neyazi, Carolina V. Arancibia-Cárcamo, Fiona Powrie, Oxford IBD Investigators, Emanuele Marchi, Raphael Sanches Peres, Val Millar, Danie Ebner, Chris Willberg, Paul Klenerman

bioRxiv 475913; doi: https://doi.org/10.1101/475913 New Results
Cell generation dynamics underlying naïve T cell homeostasis in adult humans
Jeff E. Mold, Pedro Réu, Axel Olin, Samuel Bernard, Jakob Michaëlsson, Sanket Rane, Andrew Yates, Azadeh Khosravi, Mehran Salehpour, Göran Possnert, Petter Brodin, Jonas Frisén

bioRxiv 635995; doi: https://doi.org/10.1101/635995 New Results
Complement- and inflammasome-mediated autoinflammation-paroxysmal nocturnal hemoglobinuria
Britta Hoechsmann, Yoshiko Murakami, Makiko Osato, Alexej Knaus, Michi Kawamoto, Norimitsu Inoue, Tetsuya Hirata, Shogo Murata, Markus Anliker, Thomas Eggerman, Marten Jaeger, Ricarda Floettmann, Alexander Hoellein, Sho Murase, Yasutaka Ueda, Jun-ichi Nishimura, Yuzuru Kanakura, Nobuo Kohara, Hubert Schrezenmeier, Peter M. Krawitz, Taroh Kinoshita

bioRxiv 635573; doi: https://doi.org/10.1101/635573 New Results
MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition
Lieselotte Vande Walle, Irma B. Stowe, Pavel Šácha, Bettina L. Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H. V. Saavedra, Petr Šimon, Vladimír Šubrt, Libor Kostka, Craig E. Stivala, Victoria C. Pham, Steven T. Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi

bioRxiv 634493; doi: https://doi.org/10.1101/634493 New Results
Mouse IgG2a antibodies specific for the commensal Streptococcus mitis show stronger cross-reactivity with Streptococcus pneumoniae than IgG1 antibodies
Sudhanshu Shekhar, Rabia Khan, Ata Ul Razzaq Khan, Fernanda Cristina Petersen

bioRxiv 635235; doi: https://doi.org/10.1101/635235 New Results
Peptides derived of kunitz-type serine protease inhibitor as potential vaccine against experimental schistosomiasis
Juan Hernández-Goenaga, Julio López-Abán, Anna V. Protasio, Belén Vicente Santiago, Esther del Olmo, Magnolia Vanegas, Pedro Fernández-Soto, Manuel Alfonso Patarroyo, Antonio Muro

bioRxiv 634360; doi: https://doi.org/10.1101/634360 New Results
Monocytes from Older Adults Maintain Capacity for Metabolic Compensation during Glucose Deprivation and Lipopolysaccharide Stimulation
Johnathan R. Yarbro, Brandt D. Pence

bioRxiv 633354; doi: https://doi.org/10.1101/633354 New Results

Immunology

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