Immunology

Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip
G. Goyal, P. Prabhala, G. Mahajan, B. Bausk, T. Gilboa, L. Xie, Y. Zhai, R. Lazarovits, A. Mansour, Min Sun Kim, D. Curran, J. M. Long, S. Sharma, L. Cohen, O. Levy, R. Prantil-Baun, D.R. Walt, D.E. Ingber

bioRxiv 806505; doi: https://doi.org/10.1101/806505 New Results

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Fragmentation of macrophages during isolation confounds analysis of single cell preparations from mouse hematopoietic tissues
Susan M Millard, Ostyn Heng, Khatora S Opperman, Anuj Sehgal, Katharine M Irvine, Simranpreet Kaur, Kim M Summers, Cheyenne J Sandrock, Andy C Wu, Graham W Magor, Lena Batoon, Andrew C Perkins, Jacqueline E Noll, Andrew CW Zannettino, David P Sester, Jean-Pierre Levesque, David A Hume, Liza J Raggatt, Allison R Pettit

bioRxiv 2021.04.28.441876; doi: https://doi.org/10.1101/2021.04.28.441876 New Results

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Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent immunogenicity capable of single-dose protection
Kylie M. Konrath, Kevin Liaw, Yuanhan Wu, Xizhou Zhu, Susanne N. Walker, Ziyang Xu, Katherine Schultheis, Neethu Chokkalingam, Jianqiu Du, Nicholas J. Tursi, Alan Moore, Mansi Purwar, Emma L. Reuschel, Drew Frase, Matthew Sullivan, Igor Maricic, Viviane M. Andrade, Christel Iffland, Kate E. Broderick, Laurent M. P. F. Humeau, Trevor R.F. Smith, Jesper Pallesen, David B. Weiner, Daniel W. Kulp

bioRxiv 2021.04.28.441474; doi: https://doi.org/10.1101/2021.04.28.441474 New Results

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Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body
Conde C Domínguez, T Gomes, LB Jarvis, C Xu, SK Howlett, DB Rainbow, O Suchanek, HW King, L Mamanova, K Polanski, N Huang, E Fasouli, KT Mahbubani, M Prete, L Campos, HS Mousa, EJ Needham, S Pritchard, T Li, R Elmentaite, J Park, DK Menon, OA Bayraktar, LK James, KB Meyer, MR Clatworthy, K Saeb-Parsy, JL Jones, SA Teichmann

bioRxiv 2021.04.28.441762; doi: https://doi.org/10.1101/2021.04.28.441762 New Results

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A spike-ferritin nanoparticle vaccine induces robust innate immune activity and drives polyfunctional SARS-CoV-2-specific T cells
Joshua M. Carmen, Shikha Shrivastava, Zhongyan Lu, Alexander Anderson, Elaine B. Morrison, Rajeshwer S. Sankhala, Wei-Hung Chen, William C. Chang, Jessica S. Bolton, Gary R. Matyas, Nelson L. Michael, M. Gordon Joyce, Kayvon Modjarrad, Jeffrey R. Currier, Elke Bergmann-Leitner, Allison M.W. Malloy, Mangala Rao

bioRxiv 2021.04.28.441763; doi: https://doi.org/10.1101/2021.04.28.441763 New Results

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Th17 T cells and immature dendritic cells are the preferential initial targets after rectal challenge with an SIV-based replication-defective dual-reporter vector
Danijela Maric, Wesley A. Grimm, Natalie Greco, Michael D. McRaven, Angela J. Fought, Ronald S. Veazey, Thomas J. Hope

bioRxiv 2021.04.27.441720; doi: https://doi.org/10.1101/2021.04.27.441720 New Results

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Helios is a marker, not a driver, of human Treg stability
Avery J. Lam, Prakruti Uday, Jana K. Gillies, Megan K. Levings

bioRxiv 2021.04.27.441702; doi: https://doi.org/10.1101/2021.04.27.441702 New Results

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Laser facilitated epicutaneous peptide immunization using dry patch technology
Sandra Scheiblhofer, Stephan Drothler, Werner Braun, Reinhard Braun, Maximilian Boesch, Richard Weiss

bioRxiv 2021.04.27.441719; doi: https://doi.org/10.1101/2021.04.27.441719 New Results

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APRANK: computational prioritization of antigenic proteins and peptides from complete pathogen proteomes
Alejandro D. Ricci, Mauricio Brunner, Diego Ramoa, Santiago J. Carmona, Morten Nielsen, Fernán Agüero

bioRxiv 2021.04.27.441630; doi: https://doi.org/10.1101/2021.04.27.441630 New Results

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Identification and Characterization of Human Activation-Induced ChAT⁺CD4⁺ T Cells
L Tarnawski, AL Gallina, EJ Kort, VS Shavva, Z Zhuge, D Martínez-Enguita, M Weiland, AS Caravaca, S Schmidt, FH Wang, A Färnert, E Weitzberg, M Gustafsson, M Eberhardson, H Hult, J Kehr, SG Malin, M Carlström, S Jovinge, PS Olofsson

bioRxiv 2021.04.27.441632; doi: https://doi.org/10.1101/2021.04.27.441632 New Results

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Immunology

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