Immunology

Immunogenicity and safety in pigs of PHH-1V, a SARS-CoV-2 RBD fusion heterodimer vaccine candidate
Alexandra Moros, Antoni Prenafeta, Antonio Barreiro, Eva Perozo, Alex Fernández, Manuel Cañete, Luis González, Carme Garriga, Edwards Pradenas, Silvia Marfil, Julià Blanco, Paula Cebollada Rica, Marta Sisteré-Oró, Andreas Meyerhans, Teresa Prat Cabañas, Ricard March, Laura Ferrer

bioRxiv 2023.01.19.524684; doi: https://doi.org/10.1101/2023.01.19.524684 New Results

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Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages
Delphine Bonhomme, Ignacio Santecchia, Pedro Escoll, Stylianos Papadopoulos, Frédérique Vernel-Pauillac, Ivo G. Boneca, Catherine Werts

bioRxiv 2022.08.24.505079; doi: https://doi.org/10.1101/2022.08.24.505079 New Results

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Enhancing CAR T cell therapy using Fab-Based Constitutively Heterodimeric Cytokine Receptors
Matteo Righi, Isaac Gannon, Matthew Robson, Saket Srivastava, Evangelia Kokalaki, Thomas Grothier, Francesco Nannini, Christopher Allen, Bai Yuchen, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pule

bioRxiv 2023.04.24.538039; doi: https://doi.org/10.1101/2023.04.24.538039 New Results

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Extracellular release of damaged mitochondria induced by cytotoxic conditioning exacerbates GVHD
Vijith Vijayan, Hao Yan, Juliane K. Lohmeyer, Kaylin A. Prentiss, Rachna V. Patil, Giulia Barbarito, Ivan Lopez, Aly Elezaby, Kolten Peterson, Jeanette Baker, Nicolai P. Ostberg, Alice Bertaina, Robert S. Negrin, Daria Mochly-Rosen, Kenneth Weinberg, Bereketeab Haileselassie

bioRxiv 2023.04.24.538141; doi: https://doi.org/10.1101/2023.04.24.538141 New Results

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Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift
Ge Song, Meng Yuan, Hejun Liu, Tazio Capozzola, Ryan N. Lin, Jonathan L. Torres, Wan-ting He, Rami Musharrafieh, Katharina Dueker, Panpan Zhou, Sean Callaghan, Nitesh Mishra, Peter Yong, Fabio Anzanello, Gabriel Avillion, Anh Lina Vo, Xuduo Li, Muzamil Makhdoomi, Ziqi Feng, Xueyong Zhu, Linghang Peng, David Nemazee, Yana Safonova, Bryan Briney, Andrew B Ward, Dennis R. Burton, Ian A. Wilson, Raiees Andrabi

bioRxiv 2023.04.26.538488; doi: https://doi.org/10.1101/2023.04.26.538488 New Results

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Distinct CD3⁺ CD14⁺ T Cell-Monocytes are dynamic complexes that harbor HIV and are increased with glucose intolerance
Celestine N. Wanjalla, Joshua Simmons, Jared Oakes, Xiuqi Zhang, Cindy Nochowicz, Stephen Priest, Samuel S. Bailin, Christopher M. Warren, Mona Mashayekhi, Heather K. Beasley, Jian Wang, Leslie Meenderink, Quanhu Sheng, Joey Stolze, Rama Gangula, Abha Chopra, Curtis L. Gabriel, Tecla Temu, Suman Pakala, Erin M. Wilfong, Sara Gianella, Elizabeth J. Phillips, David G. Harrison, Antentor Hinton, Spyros A. Kalams, Simon A. Mallal, John R. Koethe

bioRxiv 2023.04.24.538020; doi: https://doi.org/10.1101/2023.04.24.538020 New Results

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Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice
Katherine S Lee, Nathaniel A Rader, Olivia A Miller, Melissa Cooper, Ting Y Wong, Md. Shahrier Amin, Mariette Barbier, Justin R Bevere, Robert K Ernst, F. Heath Damron

bioRxiv 2023.04.25.538294; doi: https://doi.org/10.1101/2023.04.25.538294 New Results

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Duox and Jak/Stat signalling influence disease tolerance in Drosophila during Pseudomonas entomophila infection
Arun Prakash, Katy M. Monteith, Mickael Bonnet, Pedro F. Vale

bioRxiv 2021.09.23.461578; doi: https://doi.org/10.1101/2021.09.23.461578 New Results

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A Quadrivalent mRNA immunization elicits potent immune responses against vaccinia and monkeypox viral antigens – a step closer to a broad orthopoxvirus vaccine
Caixia Su, Yang Wen, Xiya Geng, Chunmei Yang, Quanyi Yin, Yelin Xiong, Zhihua Liu

bioRxiv 2023.04.23.537951; doi: https://doi.org/10.1101/2023.04.23.537951 New Results

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No evidence for trans-generational immune priming in Drosophila melanogaster
R. Radhika, Brian P. Lazzaro

bioRxiv 2023.04.25.538340; doi: https://doi.org/10.1101/2023.04.25.538340 New Results

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Immunology

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