Immunology

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
Annalisa D’Avola, Nathalie Legrave, Mylène Tajan, Probir Chakravarty, Ryan L. Shearer, Hamish W. King, Eric C. Cheung, Andrew J. Clear, Arief Gunawan, Lingling Zhang, Louisa K. James, James I. MacRae, John G. Gribben, Dinis P. Calado, Karen H. Vousden, John C. Riches

bioRxiv 2021.11.11.468272; doi: https://doi.org/10.1101/2021.11.11.468272 New Results

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STAT1 Gain-of-Function Variants Drive Altered T Cell Prevalence, Metabolism, and Heightened IL-6 Sensitivity
Saara Kaviany, Todd Bartkowiak, Daniel E. Dulek, Yasmin W. Khan, Madeline J. Hayes, Samuel Schaefer, Debolanle O. Dahunsi, James A. Connelly, Jonathan M. Irish, Jeffrey C. Rathmell

bioRxiv 2021.11.10.468135; doi: https://doi.org/10.1101/2021.11.10.468135 New Results

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A Physiometric Investigation of Inflammatory Composites: Comparison of “A Priori” Aggregates, Empirically-identified Factors, and Individual Proteins
Daniel P. Moriarity, Lauren M. Ellman, Christopher L. Coe, Thomas M. Olino, Lauren B. Alloy

bioRxiv 2021.06.21.449259; doi: https://doi.org/10.1101/2021.06.21.449259 New Results

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SARS-CoV-2 Envelope protein (E) binds and activates TLR2: A novel target for COVID-19 interventions
Rémi Planès, Jean-Baptiste Bert, Sofiane Tairi, Lbachir Benmohamed, Elmostafa Bahraoui

bioRxiv 2021.11.10.468173; doi: https://doi.org/10.1101/2021.11.10.468173 New Results

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Newly recruited intraepithelial Ly6A⁺CCR9⁺CD4⁺ T cells protect against enteric viral infection
Roham Parsa, Mariya London, Tiago Bruno Rezende de Castro, Bernardo Reis, Julian Buissant des Amorie, Jason G. Smith, Daniel Mucida

bioRxiv 2021.11.10.468106; doi: https://doi.org/10.1101/2021.11.10.468106 New Results

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A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
Lucie Jelínková, Yevel Flores-Garcia, Sarah Shapiro, Bryce T. Roberts, Nikolai Petrovsky, Fidel Zavala, Bryce Chackerian

bioRxiv 2021.11.10.465032; doi: https://doi.org/10.1101/2021.11.10.465032 New Results

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Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge
Michael D. Claiborne, Srona Sengupta, Liang Zhao, Matthew L. Arwood, Im-Meng Sun, Jiayu Wen, Elizabeth A. Thompson, Marisa Mitchell-Flack, Marikki Laiho, Jonathan D. Powell

bioRxiv 2021.11.10.468070; doi: https://doi.org/10.1101/2021.11.10.468070 New Results

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Increased frequency of CD4⁺ and CD8⁺ follicular helper T cells in human lymph node biopsies during the earliest stages of rheumatoid arthritis
Dornatien C. Anang, Tamara H. Ramwadhdoebe, Janine Hahnlein, Bo van Kuijk, N. Smits, Krijn P. van Lienden, Mario Maas, Danielle M. Gerlag, Paul P. Tak, Niek de Vries, Lisa G. van Baarsen

bioRxiv 2021.11.10.467883; doi: https://doi.org/10.1101/2021.11.10.467883 New Results

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Clinically relevant SMAC mimetics do not enhance human T cell proliferation or cytokine production
Ashley Burton, Brittany Ligman, Claire Kearney, Susan E. Murray

bioRxiv 2021.11.09.466489; doi: https://doi.org/10.1101/2021.11.09.466489 Contradictory Results

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B cell clonal expansion is correlated with antigen-specificity in young but not old mice
Andreas Agrafiotis, Daniel Neumeier, Kai-Lin Hong, Tasnia Chowdhury, Roy Ehling, Raphael Kuhn, Ioana Sandu, Victor Kreiner, Dale Starkie, Daniel J. Lightwood, Annette Oxenius, Sai T. Reddy, Alexander Yermanos

bioRxiv 2021.11.09.467876; doi: https://doi.org/10.1101/2021.11.09.467876 New Results

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Immunology

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