Immunology

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells
Eliza Mari Kwesi-Maliepaard, Muhammad Assad Aslam, Mir Farshid Alemdehy, Teun van den Brand, Chelsea McLean, Hanneke Vlaming, Tibor van Welsem, Tessy Korthout, Cesare Lancini, Sjoerd Hendriks, Tomasz Ahrends, Dieke van Dinther, Joke M.M. den Haan, Jannie Borst, Elzo de Wit, Fred van Leeuwen, Heinz Jacobs

bioRxiv 826255; doi: https://doi.org/10.1101/826255 New Results

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Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells
J.L. Carvalho, M. Miranda, A.K. Fialho, H. Castro-Faria-Neto, E. Anatriello, A.C. Keller, F. Aimbire

bioRxiv 843433; doi: https://doi.org/10.1101/843433 New Results

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Genome-wide profiling of druggable active tumor defense mechanisms to enhance cancer immunotherapy
Rigel J. Kishton, Shashank J. Patel, Suman K. Vodnala, Amy E. Decker, Yogin Patel, Madhusudhanan Sukumar, Tori N. Yamamoto, Zhiya Yu, Michelle Ji, Amanda N. Henning, Devikala Gurusamy, Douglas C. Palmer, Winifred Lo, Anna Pasetto, Parisa Malekzadeh, Drew C. Deniger, Kris C. Wood, Neville E. Sanjana, Nicholas P. Restifo

bioRxiv 843185; doi: https://doi.org/10.1101/843185 New Results

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Single cell multiomic analysis of T cell exhaustion in vitro
Mirko Corselli, Suraj Saksena, Margaret Nakamoto, Woodrow E. Lomas III, Ian Taylor, Pratip K. Chattopadhyay

bioRxiv 846048; doi: https://doi.org/10.1101/846048 New Results

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RNA sequencing and lipidomic analysis of alveolar macrophages from normal and CD44 deficient mice
Yifei Dong, Arif A. Arif, Jian Guo, Zongyi Ha, Sally S. M. Lee-Sayer, Grace F. T. Poon, Manisha Dosanjh, Calvin D. Roskelley, Tao Huan, Pauline Johnson

bioRxiv 845644; doi: https://doi.org/10.1101/845644 New Results

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Endocrine autoimmune disease as a fragility of immune-surveillance against hypersecreting mutants
Yael Korem Kohanim, Avichai Tendler, Avi Mayo, Nir Friedman, Uri Alon

bioRxiv 845750; doi: https://doi.org/10.1101/845750 New Results

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A Framework of All Discovered Immunological Pathways and Their Roles for Four Specific Types of Pathogens and Hypersensitivities
Wan-Chung Hu

bioRxiv 006965; doi: https://doi.org/10.1101/006965 Confirmatory Results

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Defined microbiota transplant restores Th17/RORγt⁺ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
Graham J. Britton, Eduardo J. Contijoch, Matthew P. Spindler, Varun Aggarwala, Gerold Bongers, Lani San Mateo, Andrew Baltus, Anuk Das, Dirk Gevers, Thomas J. Borody, Nadeem O. Kaakoush, Michael A. Kamm, Hazel Mitchell, Sudarshan Paramsothy, Jose C. Clemente, Jean-Frederic Colombel, Marla C. Dubinsky, Ari Grinspan, Jeremiah J. Faith

bioRxiv 844662; doi: https://doi.org/10.1101/844662 New Results

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Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells
Qingtai Su, Aurélie Bouteau, Jacob Cardenas, Balaji Uthra, Yuanyaun Wang, Cynthia Smitherman, Jinghua Gu, Botond Z. Igyártó

bioRxiv 844530; doi: https://doi.org/10.1101/844530 New Results

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An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans
Nazish Sayed, Tianxiang Gao, Robert Tibshirani, Trevor Hastie, Lu Cui, Tatiana Kuznetsova, Yael Rosenberg-Hasson, Rita Ostan, Daniela Monti, Benoit Lehallier, Shai Shen-Orr, Holden T. Maecker, Cornelia L. Dekker, Tony Wyss-Coray, Claudio Franceschi, Vladimir Jojic, François Haddad, José G. Montoya, Joseph C. Wu, David Furman

bioRxiv 840363; doi: https://doi.org/10.1101/840363 New Results

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Immunology

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