Immunology

T cell-instructed inflammation drives immune checkpoint inhibitor therapy resistance
Nam Woo Cho, Sophia M. Guldberg, Eun Ji Kim, Kamir J. Hiam-Galvez, Katherine Wai, Lauren S. Levine, Barzin Y. Nabet, Rachel DeBarge, Jacqueline L. Yee, Naa Asheley Ashitey, Iliana Tenvooren, Matthew H. Spitzer

bioRxiv 2022.09.20.508732; doi: https://doi.org/10.1101/2022.09.20.508732 New Results

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Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans
Veronica Locher, Sara Park, Daniel Bunis, Stephanie Makredes, Trevor D. Burt, Gabriela K. Fragiadakis, Joanna Halkias

bioRxiv 2022.09.19.508328; doi: https://doi.org/10.1101/2022.09.19.508328 New Results

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Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice
Alexander Muik, Bonny Gaby Lui, Maren Bacher, Ann-Kathrin Wallisch, Aras Toker, Carla Iris Cadima Couto, Alptekin Güler, Veena Mampilli, Geneva J. Schmitt, Jonathan Mottl, Thomas Ziegenhals, Stephanie Fesser, Jonas Reinholz, Florian Wernig, Karla-Gerlinde Schraut, Hossam Hefesha, Hui Cai, Qi Yang, Kerstin C. Walzer, Jessica Grosser, Stefan Strauss, Andrew Finlayson, Kimberly Krüger, Orkun Ozhelvaci, Katharina Grikscheit, Niko Kohmer, Sandra Ciesek, Kena A. Swanson, Annette B. Vogel, Özlem Türeci, Ugur Sahin

bioRxiv 2022.09.21.508818; doi: https://doi.org/10.1101/2022.09.21.508818 New Results

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A hierarchy of cell death pathways confers layered resistance to shigellosis in mice
Justin L Roncaioli, Janet Peace Babirye, Roberto A Chavez, Fitty L Liu, Elizabeth A Turcotte, Angus Y Lee, Cammie F Lesser, Russell E Vance

bioRxiv 2022.09.21.508939; doi: https://doi.org/10.1101/2022.09.21.508939 New Results

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Transcription coactivator OCA-B/Pou2af1 is necessary and sufficient to promote T cell-intrinsic CD4 memory
Wenxiang Sun, Heejoo Kim, Jelena Perovanovic, Erik Hughes, Junhong Du, Andrea Ibarra, J. Scott Hale, Matthew A. Williams, Dean Tantin

bioRxiv 2022.09.21.508912; doi: https://doi.org/10.1101/2022.09.21.508912 New Results

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Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli
Sharon A. McGrath-Morrow, Jarrett Venezia, Roland Ndeh, Benjamin D. Singer, Raffaello Cimbro, Mark Soloski, Alan L. Scott

bioRxiv 2022.09.21.508849; doi: https://doi.org/10.1101/2022.09.21.508849 New Results

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Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection
Gregory M. Martin, Jonathan L. Torres, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Grace Gibson, Re’em Moskovitz, Nathan Beutler, Diana D. Jung, Jeffrey Copps, Wen-Hsin Lee, Gonzalo Gonzalez-Paez, Daniel Emerling, Randall S. MacGill, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson, Andrew B. Ward

bioRxiv 2022.09.20.508747; doi: https://doi.org/10.1101/2022.09.20.508747 New Results

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Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans
Amanda JL Ridley, Yaqing Ou, Richard Karlsson, Nabina Pun, Holly L Birchenough, Thomas A Jowitt, Craig Lawless, Rebecca L Miller, Douglas P Dyer

bioRxiv 2022.09.20.508420; doi: https://doi.org/10.1101/2022.09.20.508420 New Results

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Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis
Yao Zihao, Qi Weizhong, Liu Liangliang, Shao Yan, Zhang Hongbo, Yin Jianbin, Pan Haoyan, Guo Xiongtian, Liu Anling, Cai Daozhang, Bai Xiaochun, Zhang Haiyan

bioRxiv 2022.09.20.508661; doi: https://doi.org/10.1101/2022.09.20.508661 New Results

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VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis
Jiaqian Li, Di Huang, Bingxi Lei, Jingying Huang, Qiyi Zhao, Shicheng Su, Ying Wang

bioRxiv 2022.09.20.508709; doi: https://doi.org/10.1101/2022.09.20.508709 New Results

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Immunology

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