Immunology

Reference-based annotation of single cell transcriptomes identifies a profibrotic macrophage niche after tissue injury
Dvir Aran, Agnieszka P. Looney, Leqian Liu, Valerie Fong, Austin Hsu, Paul J. Wolters, Adam Abate, Atul J. Butte, Mallar Bhattacharya

bioRxiv 284604; doi: https://doi.org/10.1101/284604

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Synthetic standards combined with error and bias correction improves the accuracy and quantitative resolution of antibody repertoire sequencing in human naïve and memory B cells
Simon Friedensohn, John M. Lindner, Vanessa Cornacchione, Mariavittoria Iazeolla, Enkelejda Miho, Andreas Zingg, Simon Meng, Elisabetta Traggiai, Sai T. Reddy

bioRxiv 284810; doi: https://doi.org/10.1101/284810

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High dimensional analyses of cells dissociated from cryopreserved synovial tissue
Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure, Shuqiang Li, Edward P. Browne, Adam Chicoine, Danielle Sutherby, Akiko Noma, Accelerating Medicines Partnership: RA/SLE Network, Chad Nusbaum, Stephen Kelly, Alessandra B. Pernis, Lionel B. Ivashkiv, Susan M. Goodman, William H. Robinson, Paul J. Utz, James A. Lederer, Ellen M. Gravallese, Brendan F. Boyce, Nir Hacohen, Costantino Pitzalis, Peter K. Gregersen, Gary S. Firestein, Soumya Raychaudhuri, Larry W. Moreland, V. Michael Holers, Vivian P. Bykerk, Andrew Filer, David L. Boyle, Michael B. Brenner, Jennifer H. Anolik

bioRxiv 284844; doi: https://doi.org/10.1101/284844

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A constitutively expressed antifungal peptide protects Tenebrio molitor during a natural infection by the entomopathogenic fungus Beauveria bassiana
Sevasti Maistrou, Véronique Paris, Annette B. Jensen, Jens Rolff, Nicolai V. Meyling, Caroline Zanchi

bioRxiv 284778; doi: https://doi.org/10.1101/284778

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The expansion in lymphoid organs of IL-4⁺ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo
Takashi Maehara, Hamid Mattoo, Vinay S. Mahajan, Samuel J.H. Murphy, Grace J. Yuen, Noriko Ishiguro, Miho Ohta, Masafumi Moriyama, Takako Saeki, Hidetaka Yamamoto, Masaki Yamauchi, Joe Daccache, Tamotsu Kiyoshima, Seiji Nakamura, John H. Stone, Shiv Pillai

bioRxiv 284737; doi: https://doi.org/10.1101/284737

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Elucidating the activation mechanisms for bifurcation of regulatory and effector T cell fates by multidimensional single cell analysis
Alla Bradley, Tetsuo Hashimoto, Masahiro Ono

bioRxiv 280818; doi: https://doi.org/10.1101/280818

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PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Sriskantharajah, Glyn Bradley, Alex G. Richter, Edward Banham-Hall, Menna R. Clatworthy, Sergey Nejentsev, J. Nicole Hamblin, Edith M. Hessel, Alison M. Condliffe, Klaus Okkenhaug

bioRxiv 280651; doi: https://doi.org/10.1101/280651

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Distinct housing conditions reveal a major impact of adaptive immunity on the course of obesity-induced type 2 diabetes
Julia Sbierski-Kind, Jonas Kath, Sebastian Brachs, Mathias Streitz, Matthias v. Herrath, Anja A. Kühl, Katharina Schmidt-Bleek, Knut Mai, Joachim Spranger, Hans-Dieter Volk

bioRxiv 282921; doi: https://doi.org/10.1101/282921

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Immunostimulatory guide RNAs mediate potent antiviral response
Yujia Cai, Alice Knudsen, Samuel Joseph Windross, Martin K Thomsen, Søren R Paludan

bioRxiv 282558; doi: https://doi.org/10.1101/282558

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Increased susceptibility to intracellular bacteria and necrotic inflammation driven by a dysregulated macrophage response to TNF
Bidisha Bhattacharya, Sujoy Chattrerjee, Robert Berland, Alexander Pichugin, Yuanwei Gao, John Connor, Alexander Ivanov, Bo-Shiun Yan, Lester Kobzik, Igor Kramnik

bioRxiv 238873; doi: https://doi.org/10.1101/238873

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Immunology

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