Pharmacology and Toxicology

The off-target kinase landscape of clinical PARP inhibitors
Albert A. Antolin, Malaka Ameratunga, Udai Banerji, Paul Clarke, Paul Workman, Bissan Al-Lazikani

bioRxiv 520023; doi: https://doi.org/10.1101/520023 New Results
A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify Emerging Metabolic Health Threats
Stephanie Kim, Eric Reed, Stefano Monti, Jennifer Schlezinger

bioRxiv 519629; doi: https://doi.org/10.1101/519629 New Results
Behavioural Evaluation of the Anticonvulsant Properties of the Traditional Medicine Anonna Senegalensis on Parabss Drosophila melanogaster Mutants.
Samuel Dare, Emiliano Merlo, Peter E Ekanem, Jimena Berni

bioRxiv 519322; doi: https://doi.org/10.1101/519322 New Results
Reversible silencing of endogenous receptors in intact brain tissue using two-photon pharmacology
Silvia Pittolo, Hyojung Lee, Anna Lladó, Sébastien Tosi, Miquel Bosch, Lídia Bardia, Xavier Gómez-Santacana, Amadeu Llebaria, Eduardo Soriano, Julien Colombelli, Kira E Poskanzer, Gertrudis Perea, Pau Gorostiza

bioRxiv 515288; doi: https://doi.org/10.1101/515288 New Results
Live applications of norbormide-based fluorescent probes in Drosophila melanogaster
Alessia Forgiarini, Zifei Wang, Claudio D'Amore, Morgan Jay-Smith, Freda Fan Li, Brian Hopkins, Margaret Anne Brimble, Andrea Pagetta, Sara Bersani, Sara De Martin, Barbara Napoli, Sergio Bova, David Rennison, Genny Orso

bioRxiv 517334; doi: https://doi.org/10.1101/517334 New Results
Calcitriol and Non-Calcemic Vitamin D Analogue, 22 Oxacalcitriol, Attenuate Developmental and Pathological Ocular Angiogenesis Ex Vivo and In Vivo
Stephanie Merrigan, Bomina Park, Zaheer Ali, Lasse Jensen, Timothy Corson, Breandan Kennedy

bioRxiv 515387; doi: https://doi.org/10.1101/515387 New Results
A novel rationale for targeting FXI: Insights from the hemostastic miRNA targetome for emerging anticoagulant strategies
Jamie Nourse, Sven Danckwardt

bioRxiv 501676; doi: https://doi.org/10.1101/501676 New Results
Contribution of pretomanid to novel regimens containing bedaquiline with either linezolid or moxifloxacin and pyrazinamide in murine models of tuberculosis
Jian Xu, Si-Yang Li, Deepak Almeida, Rokeya Tasneen, Kala Barnes-Boyle, Paul J Converse, Anna M Upton, Khisimuzi Mdluli, Nader Fotouhi, Eric Nuermberger

bioRxiv 514661; doi: https://doi.org/10.1101/514661 New Results
Evaluation of liver protective activity of Moringa oleifera bark extract in paracetamol induced hepatotoxicity in rats.
Rajibul Islam, Md. Jahir Alam

bioRxiv 513002; doi: https://doi.org/10.1101/513002 New Results
Kinome-wide activity classification of small molecules by deep learning
Bryce K Allen, Nagi G Ayad, Stephan C Schürer

bioRxiv 512459; doi: https://doi.org/10.1101/512459 New Results

Pharmacology and Toxicology

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