Pharmacology and Toxicology

Exploiting toxin internalization receptors to enhance delivery of proteins to lysosomes for enzyme replacement therapy
Seiji Sugiman-Marangos, Greg L Beilhartz, Xiaochu Zhao, Dongxia Zhou, Rong Hua, Peter K Kim, James M Rini, Berge A Minassian, Roman A Melnyk

bioRxiv 2020.01.22.915298; doi: https://doi.org/10.1101/2020.01.22.915298 New Results

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Hesperetin inhibits foam cell formation in macrophages via activating LXRα signal in an AMPK dependent manner
Xuanjing Chen, Dezhi Zou, Xiaoling Chen, Huanlin Wu, Danping Xu

bioRxiv 2020.01.22.915819; doi: https://doi.org/10.1101/2020.01.22.915819 New Results

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Toxic effect of 2,2’-bis(bicyclo[2.2.1] heptane) on bacterial cells
A. G. Kessenikh, E. Yu. Gnuchikh, S. V. Bazhenov, M. V. Bermeshev, V. G. Pevgov, V. O. Samoilov, S. V. Shorunov, A. L. Maksimov, L. S. Yaguzhinsky, I. V. Manukhov

bioRxiv 2020.01.21.913699; doi: https://doi.org/10.1101/2020.01.21.913699 New Results

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Functional anatomy of the full length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis
Bryan S. Stephens, Tony Ngo, Irina Kufareva, Tracy M. Handel

bioRxiv 2020.01.21.913772; doi: https://doi.org/10.1101/2020.01.21.913772 New Results

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Effect of Perfluorooctanesulfonic acid (PFOS) on immune cell development and function in mice
Luisa Torres, Amie Redko, Candice Limper, Brian Imbiakha, Sue Chang, Avery August

bioRxiv 2020.01.20.913293; doi: https://doi.org/10.1101/2020.01.20.913293 New Results

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Schisandrin B for treatment of male infertility
Di-Xin Zou, Xue-Dan Meng, Ying Xie, Rui Liu, Jia-Lun Duan, Chun-Jie Bao, Yi-Xuan Liu, Ya-Fei Du, Jia-Rui Xu, Qian Luo, Zhan Zhang, Shuang Ma, Wei-Peng Yang, Rui-Chao Lin, Wan-Liang Lu

bioRxiv 2020.01.20.912147; doi: https://doi.org/10.1101/2020.01.20.912147 New Results

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Analyzing kinetic signaling data for G-protein-coupled receptors
Sam R.J. Hoare, Paul H. Tewson, Anne Marie Quinn, Thomas E. Hughes, Lloyd J. Bridge

bioRxiv 2020.01.20.913319; doi: https://doi.org/10.1101/2020.01.20.913319 New Results

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DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery
NJ Kapolka, GJ Taghon, JB Rowe, WM Morgan, JF Enten, DG Isom

bioRxiv 2020.01.16.909325; doi: https://doi.org/10.1101/2020.01.16.909325 New Results

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Cytotoxic Activity Of A New Isoform L-Amino Acid Oxidase (Balt-LAAO-II) From Bothrops alternatus (Urutu) Snake Venom In Human Leukemic HL60 Cells
Maurício Aurelio Gomes Heleno, João Ernesto de Carvalho, Alexandre Nowill, Luis Alberto Ponce-Soto

bioRxiv 2020.01.15.907758; doi: https://doi.org/10.1101/2020.01.15.907758 New Results

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Statistical analysis of no observed effect concentrations or levels in eco-toxicological assays with overdispersed count endpoints
Ludwig A. Hothorn, Felix M. Kluxen

bioRxiv 2020.01.15.907881; doi: https://doi.org/10.1101/2020.01.15.907881 New Results

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Pharmacology and Toxicology

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