Pharmacology and Toxicology

Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone receptor 1
Christoph Klenk, Leif Hommers, Martin J. Lohse

bioRxiv 2021.12.16.472984; doi: https://doi.org/10.1101/2021.12.16.472984 New Results

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Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature
Maria-Anna Trapotsi, Elizabeth Mouchet, Guy Williams, Tiziana Monteverde, Karolina Juhani, Riku Turkki, Filip Miljković, Anton Martinsson, Lewis Mervin, Erik Müllers, Ian Barrett, Ola Engkvist, Andreas Bender, Kevin Moreau

bioRxiv 2022.01.17.476610; doi: https://doi.org/10.1101/2022.01.17.476610 New Results

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Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina
Tom Driedonks, Linglei Jiang, Bess Carlson, Zheng Han, Guanshu Liu, Suzanne E. Queen, Erin N. Shirk, Olesia Gololobova, Lyle H. Nyberg, Gabriela Lima, Liliia Paniushkina, Marta Garcia-Contreras, Kayla Schonvisky, Natalie Castell, Mitchel Stover, Selena Guerrero-Martin, Riley Richardson, Barbara Smith, Vasiliki Mahairaki, Charles P. Lai, Jessica M. Izzi, Eric K. Hutchinson, Kelly A.M. Pate, Kenneth W. Witwer

bioRxiv 2021.07.28.454192; doi: https://doi.org/10.1101/2021.07.28.454192 New Results

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Inhibition of the JAK/STAT pathway with baricitinib reduces the multiple organ dysfunction caused by hemorrhagic shock in rats
Nikita Mayur Patel, Debora Collotta, Eleonora Aimaretti, Gustavo Ferreira Alves, Sarah Kröller, Sina Maren Coldewey, Massimo Collino, Christoph Thiemermann

bioRxiv 2022.01.13.476088; doi: https://doi.org/10.1101/2022.01.13.476088 New Results

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An in silico method to assess antibody fragment polyreactivity
Edward P. Harvey, Jung-Eun Shin, Meredith A. Skiba, Genevieve R. Nemeth, Joseph D. Hurley, Alon Wellner, Ada Y. Shaw, Victor G. Miranda, Joseph K. Min, Chang C. Liu, Debora S. Marks, Andrew C. Kruse

bioRxiv 2022.01.12.476085; doi: https://doi.org/10.1101/2022.01.12.476085 New Results

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Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac function
Martina Arici, Mara Ferrandi, Paolo Barassi, Shih-Che Hsu, Eleonora Torre, Andrea Luraghi, Carlotta Ronchi, Gwo-Jyh Chang, Francesco Peri, Patrizia Ferrari, Giuseppe Bianchi, Marcella Rocchetti, Antonio Zaza

bioRxiv 2021.08.17.455204; doi: https://doi.org/10.1101/2021.08.17.455204 New Results

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Potentiation of drug toxicity through virus latency reversal promotes preferential elimination of HIV infected cells
Thanh Tung Truong, Manuel Hayn, Camilla Kaas Frich, Lucy Kate Ladefoged, Morten T. Jarlstad Olesen, Josefine H. Jakobsen, Cherie K. Lunabjerg, Birgit Schiøtt, Jan Münch, Alexander N. Zelikin

bioRxiv 2022.01.12.476003; doi: https://doi.org/10.1101/2022.01.12.476003 New Results

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Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein
Maria Fernanda Fernandes, John Zewen Chan, Chia Chun Joey Hung, Michelle Victoria Tomczewski, Robin Elaine Duncan

bioRxiv 2022.01.11.475901; doi: https://doi.org/10.1101/2022.01.11.475901 New Results

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Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic protection
Jane A. Mitchell, Maria Vinokurova, Maria Elisa Lopes-Pires, Fisnik Shala, Paul C. Armstrong, Blerina Ahmetaj-Shala, Youssef Elghazouli, Bin Liu, Yingbi Zhou, Chuan-ming Hao, Harvey R. Herschman, Nicholas S. Kirkby

bioRxiv 2022.01.11.475814; doi: https://doi.org/10.1101/2022.01.11.475814 New Results

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Favipiravir, umifenovir and camostat mesylate: a comparative study against SARS-CoV-2
Mehnmet Altay Unal, Omur Besbinar, Hasan Nazir, Gokce Yagmur Summak, Fatma Bayrakdar, Lucia Gemma Delogu, Tambay Taskin, Sibel Aysil Ozkan, Kamil Can Akcali, Acelya Yilmazer

bioRxiv 2022.01.11.475889; doi: https://doi.org/10.1101/2022.01.11.475889 New Results

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Pharmacology and Toxicology

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