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Pharmacology and Toxicology

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  • Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus
    Uli Schmitz, Sarah A. Gilmore, Danny Tam, Tara L. Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y. Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M. Brendza, Todd C. Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H. Tay, William E. Delaney, Gregory T. Notte, Becket Feierbach
    bioRxiv 2022.06.27.497732; doi: https://doi.org/10.1101/2022.06.27.497732 New Results
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  • Quantification of Receptor Binding from Response Data Obtained at Different Receptor Levels: A Simple Individual Sigmoid Fitting and a Unified SABRE Approach
    Peter Buchwald
    bioRxiv 2022.06.27.497811; doi: https://doi.org/10.1101/2022.06.27.497811 New Results
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  • A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer
    Chengyao Chiang, Min Zhang, Junrong Huang, Juan Zeng, Chunlan Chen, Dongmei Pan, Heng Yang, Min Yang, Qiangqiang Han, Wang Zou, Tian Xiao, Yongdong Zou, Feng Yin, Zigang Li, Lizhi Zhu, Duo Zheng
    bioRxiv 2022.06.27.497627; doi: https://doi.org/10.1101/2022.06.27.497627 New Results
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  • Safety and uptake of fully oxidized β-carotene
    Graham W. Burton, Trevor J. Mogg, Jacek Stupak, Felicity C. Stark, Susan M. Twine, Jianjun Li
    bioRxiv 2022.06.27.497750; doi: https://doi.org/10.1101/2022.06.27.497750 New Results
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  • Preclinical efficacy of bacosides-lauric acid nano-herbal formulation in comparison to rivastigmine for treatment of Alzheimer’s disease
    Ashish Kumar, Kritika Goyal, Muneesh Pal, Prabhat Upadhyay, Sarika Gupta, Veena Koul, Arpita Konar
    bioRxiv 2022.06.25.497622; doi: https://doi.org/10.1101/2022.06.25.497622 New Results
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  • Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir
    Yanmei Hu, Eric M. Lewandowski, Haozhou Tan, Ryan T. Morgan, Xiujun Zhang, Lian M. C. Jacobs, Shane G. Butler, Maura V. Mongora, John Choy, Yu Chen, Jun Wang
    bioRxiv 2022.06.28.497978; doi: https://doi.org/10.1101/2022.06.28.497978 New Results
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  • Selection Of Theaflavin 2B As a Potential HSP90 Antagonist Semi-rigid Ligand Docking Analysis
    Samuel Akinsehinwa, Oluwatobi Medayedupin
    bioRxiv 2022.06.24.497557; doi: https://doi.org/10.1101/2022.06.24.497557 New Results
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  • Toxicological study on methanol root bark extract of Acacia sieberiana (Fabaceae) in Wistar rats
    Miriam Watafua, Jane I. Ejiofor, Aminu Musa, Mubarak Hussaini Ahmad
    bioRxiv 2022.06.24.497563; doi: https://doi.org/10.1101/2022.06.24.497563 New Results
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  • Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
    Han Gao, Chengwei He, Rongxuan Hua, Chen Liang, Boya Wang, Yixuan Du, Yuexin Guo, Lei Gao, Lucia Zhang, Hongwei Shang, Jingdong Xu
    bioRxiv 2022.06.24.497289; doi: https://doi.org/10.1101/2022.06.24.497289 New Results
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  • Artemisia extracts Differ from Artemisinin Effects on Human Hepatic CYP450s 2B6 and 3A4 in vitro
    Ndeye F. Kane, Bushra H. Kiani, Matthew R. Desrosiers, Melissa J. Towler, Pamela J. Weathers
    bioRxiv 2022.06.24.497548; doi: https://doi.org/10.1101/2022.06.24.497548 New Results
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