Pharmacology and Toxicology

microRNA-544a as a new modulator of the Wnt-signalling network in the articular cartilage and osteoarthritis
Cintia Scucuglia Heluany, Nicholas James Day, Keemo DeLos Santos, Anna De Palma, Tracey E Swingler, David Sochart, Ian Clark, Mohit Kapoor, Giovanna Nalesso

bioRxiv 2024.11.28.625937; doi: https://doi.org/10.1101/2024.11.28.625937 New Results

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SS-31 protects against bleomycin-induced lung injury and fibrosis
Quankuan Gu, Yunlong Wang, Haichao Zhang, Wei Yang, Xianglin Meng, Mingyan Zhao

bioRxiv 2024.11.28.625848; doi: https://doi.org/10.1101/2024.11.28.625848 Confirmatory Results

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Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism
Madeline E Kavanagh, Kirsty J McLean, Sophie H Gilbert, Cecilia Amadi, Matthew Snee, Richard B Tunnicliffe, Kriti Arora, Helena Boshoff, Alexander Fanourakis, Maria Jose Rebello-Lopez, Fatima Ortega-Muro, Colin Levy, Andrew W Munro, David Leys, Chris Abell, Anthony G Coyne

bioRxiv 2024.10.28.620643; doi: https://doi.org/10.1101/2024.10.28.620643 New Results

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A novel RyR2-selective stabilizer prevents and ameliorates severe arrhythmias in stress-induced ventricular tachycardia
Nagomi Kurebayashi, Masami Kodama, Takashi Murayama, Masato Konishi, Masami Sugihara, Hana Inoue, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai

bioRxiv 2024.11.26.625386; doi: https://doi.org/10.1101/2024.11.26.625386 New Results

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Therapeutic effects of a purified chitin-binding protein from Moringa oleifera seeds on irinotecan-induced intestinal mucositis in mice
Kayanny Queiroz Ferreira, Luana David do Carmo, Liviane Maria Alves Rabelo, Tiago Deivison Perreira Lopes, Deysi Viviana Tenazoa Wong, Aurilene Gomes Cajado, Renata Ferreira de Carvalho Leitão, Daniele Oliveira Bezerra Sousa, Nylane Maria Nunes de Alencar

bioRxiv 2024.11.27.625542; doi: https://doi.org/10.1101/2024.11.27.625542 New Results

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A QbD strategy to develop curcumin and siRNA co-loaded lipoplexes to combat osteoarthritis-related inflammation and oxidative stress
Saketh Reddy Ranamalla, Alina Porfire, Emilia Licarete, Lucia Tefas, Rohith Pavan Parvathaneni, Oommen. P. Varghese, Alina Sesarman, Monica Focsan, Lucian Barbu Tudoran, Ioan Tomuta, Manuela Banciu

bioRxiv 2024.11.25.625050; doi: https://doi.org/10.1101/2024.11.25.625050 New Results

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Repeated administration of pharmaceutical-grade medium chain triglycerides, a common pharmacologic excipient, confers dose-dependent toxicity by the intraperitoneal but not oral route in mice*
Mitzi Adler-Wachter, Julia Y. Tsai, Brendan N. Schweitzer, Ashley McDonough, Jessica M. Snyder, Melissa Barker-Haliski, Jonathan R. Weinstein

bioRxiv 2024.11.24.625115; doi: https://doi.org/10.1101/2024.11.24.625115 New Results

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Identification of novel drug-drug interactions: towards precision medicine in women’s reproductive health
Pablo Garcia-Acero, Ismael Henarejos-Castillo, Patricia Sebastian-Leon, Antonio Parraga-Leo, Juan Antonio Garcia-Velasco, Patricia Diaz-Gimeno

bioRxiv 2024.11.25.624843; doi: https://doi.org/10.1101/2024.11.25.624843 New Results

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Suppression of cyclooxygenase-2 predisposes to heart failure with preserved ejection fraction
Emanuela Ricciotti, Philip G. Haines, Manu Beerens, Uri Kartoun, Cecilia Castro, Soon Yew Tang, Soumita Ghosh, Ujjalkumar S. Das, Nicholas F. Lahens, Tao Wang, Jules L. Griffin, Stanley Y. Shaw, Calum A. MacRae, Garret A. FitzGerald

bioRxiv 2024.09.28.615616; doi: https://doi.org/10.1101/2024.09.28.615616 New Results

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Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use
Kayla Barekat, Emanuela Ricciotti, Soumita Ghosh, Christin Herrmann, Karl Keat, Charles-Antoine Assenmacher, Ceylan Tanes, Naomi Wilson, Arjun Sengupta, Ujjalkumar Das, Robin Joshi, Marylyn Ritchie, Kyle Bittinger, Aalim Weljie, Ken Cadwell, Frederic D. Bushman, Gary Wu, Garret A. FitzGerald

bioRxiv 2024.11.22.624882; doi: https://doi.org/10.1101/2024.11.22.624882 New Results

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Pharmacology and Toxicology

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