Pharmacology and Toxicology

In-Vitro Efficacy of Targeted FODMAP Enzymatic Digestion (FODZYME®) in a High-Fidelity Simulated Gastrointestinal Environment
Kenny Castro Ochoa, Shalaka Samant, Anjie Liu, Cindy Duysburgh, Massimo Marzorati, Prashant Singh, David Hachuel, Thomas Wallach

bioRxiv 2022.05.16.492152; doi: https://doi.org/10.1101/2022.05.16.492152 New Results

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Toxic effects of elevated bile acid levels on fetal myocardium in intrahepatic cholestasis of pregnancy, a retrospective study from a neonatal perspective
Junnai Wang, Wei Shi, Weiwei Lun

bioRxiv 2022.05.16.492192; doi: https://doi.org/10.1101/2022.05.16.492192 Confirmatory Results

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Screening of hydrocarbon-stapled peptides for inhibition of calcium-triggered exocytosis
Ying Lai, Michael J. Tuvim, Jeremy Leitz, John Peters, Richard A. Pfuetzner, Luis Esquivies, Qiangjun Zhou, Barbara Czako, Jason B. Cross, Philip Jones, Burton F. Dickey, Axel T. Brunger

bioRxiv 2022.03.21.484632; doi: https://doi.org/10.1101/2022.03.21.484632 New Results

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Effects of anti-fibrotic standard of care drugs on senescent human lung fibroblasts
Stephanie B. Garcia, Miriam S. Hohmann, Ana Lucia Coelho, Waldiceu A. Verri Jr., Cory M. Hogaboam

bioRxiv 2022.05.06.490939; doi: https://doi.org/10.1101/2022.05.06.490939 New Results

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Design and validation of the first family of photo-activatable ligands for melatonin receptors
Gloria Somalo-Barranco, Carme Serra, David Lyons, Hugh D. Piggins, Ralf Jockers, Amadeu Llebaria

bioRxiv 2022.05.05.490738; doi: https://doi.org/10.1101/2022.05.05.490738 New Results

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High-resolution mass spectrometry reveals environmentally relevant uptake, elimination, and metabolic alterations following early embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish
Michelle E. Kossack, Katherine E. Manz, Nathan R. Martin, Kurt D. Pennell, Jessica Plavicki

bioRxiv 2022.05.04.490602; doi: https://doi.org/10.1101/2022.05.04.490602 New Results

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The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration
Peiru Chen, Yuan Li, Feng Xu, Zhenpeng Zhang, Tao Zuo, Jiabin Guo, Kaixuan Li, Shu Liu, Suzhen Li, Jian Yin, Lei Chang, Predrag Kukic, Mark Liddell, Liz Tulum, Paul Carmichael, Shuangqing Peng, Jin Li, Qiang Zhang, Ping Xu

bioRxiv 2022.04.07.487458; doi: https://doi.org/10.1101/2022.04.07.487458 New Results

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Visualizing cell-cell interactions between immune effector and tumor cells induced by antibodies using a proximity-dependent biosensor system
Yu Tang, Yanguang Cao

bioRxiv 2022.05.04.490615; doi: https://doi.org/10.1101/2022.05.04.490615 New Results

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Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac function
Martina Arici, Mara Ferrandi, Paolo Barassi, Shih-Che Hsu, Eleonora Torre, Andrea Luraghi, Carlotta Ronchi, Gwo-Jyh Chang, Francesco Peri, Patrizia Ferrari, Giuseppe Bianchi, Marcella Rocchetti, Antonio Zaza

bioRxiv 2021.08.17.455204; doi: https://doi.org/10.1101/2021.08.17.455204 New Results

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A Novel Chronic in vivo Oral Cadmium Exposure-Washout Mouse Model for Studying Cadmium Toxicity and Complex Diabetogenic Effects
Winifred P.S. Wong, Janice C. Wang, Matthew S. Meyers, Nathan J. Wang, Rebecca A. Sponenburg, Norrina B. Allen, Joshua E. Edwards, Malek El Muayed

bioRxiv 2022.02.21.481351; doi: https://doi.org/10.1101/2022.02.21.481351 New Results

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Pharmacology and Toxicology

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