Pharmacology and Toxicology

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An integrative model finds comparable contributions to drug resistance from poor drug adherence and adapting bacteria
Roshan P Mathews, Meher K Prakash

bioRxiv 773861; doi: https://doi.org/10.1101/773861 New Results

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Computationally Guided Design of Dipeptidyl Peptidase-4 Inhibitors
Lauren C Reynolds, Morgan P Connolly, Justin B Siegel

bioRxiv 772137; doi: https://doi.org/10.1101/772137 New Results

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Neuroprotective effects of exogenous erythropoietin in Wistar rats by downregulating apoptotic factors to attenuate N-methyl-D-aspartate-mediated retinal ganglion cells death
Wen-Sheng Cheng, I-Hung Lin, Kathy Ming Feng, Zhi-Yang Chang, Yu Chuan Huang, Da-Wen Lu

bioRxiv 773754; doi: https://doi.org/10.1101/773754 New Results

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Discovery of a small molecule having both potent anti-fibrotic and anti-inflammatory capabilities
Han-Soo Kim, Moon Kee Meang, Min-Ju Ham, Baiklin Seong, Ik-Hwan Kim, Byung-Soo Youn

bioRxiv 770404; doi: https://doi.org/10.1101/770404 New Results

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P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib
Paiyun Li, Xuehong Zhang, Liankun Gu, Jing Zhou, Dajun Deng

bioRxiv 771337; doi: https://doi.org/10.1101/771337 New Results

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A new kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework
Sam R.J. Hoare, Paul H. Tewson, Anne Marie Quinn, Thomas E. Hughes

bioRxiv 772293; doi: https://doi.org/10.1101/772293 New Results

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In vitro testing of flash-frozen sublingual membranes for storage and reproducible permeability studies of macromolecular drugs from solution or nanofiber mats
Pavel Berka, Denisa Stránská, Vladimír Semecký, Karel Berka, Pavel Doležal

bioRxiv 690990; doi: https://doi.org/10.1101/690990 New Results

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Peritubular macrophages and spermatogonia are sequentially increased in the testis of rats after mono-(2-ethylhexyl) phthalate exposure
Ross Gillette, Richa Tiwary, Jorine JLP Voss, Shavini N Hewage, John H Richburg

bioRxiv 767707; doi: https://doi.org/10.1101/767707 New Results

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An Aryl Hydrocarbon Receptor from the Caecilian Gymnopis multiplicata Suggests Low Dioxin Affinity in the Ancestor of All Three Amphibian Orders
Sarah A. Kazzaz, Sara Giani Tagliabue, Diana G. Franks, Michael S. Denison, Mark E. Hahn, Laura Bonati, Wade H. Powell

bioRxiv 750653; doi: https://doi.org/10.1101/750653 New Results

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Toxicants Associated with Spontaneous Abortion in the Comparative Toxicogenomics Database (CTD)
Sean M. Harris, Yuan Jin, Rita Loch-Caruso, Ingrid Y. Padilla, John Meeker, Kelly M. Bakulski

bioRxiv 755868; doi: https://doi.org/10.1101/755868 New Results

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