Pharmacology and Toxicology

Availability of Medications Used for Puberty Induction and Maintenance in Adolescents with Hypogonadism in the Arab Region A Deeb1*, H AlSaffar2, RT Hamza3, AM Habeb4
Asma Deeb, Hussain Al Saffar, Rasha Hamza, Abdelhadi Habeb

bioRxiv 2020.10.27.356808; doi: https://doi.org/10.1101/2020.10.27.356808 New Results

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Activating mGlu₃ metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus.
Shalini Dogra, Branden J Stansley, Zixiu Xiang, Weilun Qian, Rocco G Gogliotti, Ferdinando Nicoletti, Craig W Lindsley, Colleen M Niswender, Max E Joffe, P Jeffrey Conn

bioRxiv 2020.10.27.356196; doi: https://doi.org/10.1101/2020.10.27.356196 New Results

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Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens
Wei Jiang, Ailing Yang, Jingchuan Ma, Dawei Lv, Mingxian Liu, Liang Xu, Chao Wang, Zhengjin He, Shuo Chen, Jie Zhao, Shishuang Chen, Qi Jiang, Yankai Chu, Lin Shan, Zhaocai Zhou, Yun Zhao, Gang Long, Hai Jiang

bioRxiv 2020.10.26.356279; doi: https://doi.org/10.1101/2020.10.26.356279 New Results

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Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model
Yingjun Li, Liu Cao, Ge Li, Feng Cong, Yunfeng Li, Jing Sun, Yinzhu Luo, Guijiang Chen, Guanguan Li, Ping Wang, Fan Xing, Yanxi Ji, Jincun Zhao, Yu Zhang, Deyin Guo, Xumu Zhang

bioRxiv 2020.10.26.353300; doi: https://doi.org/10.1101/2020.10.26.353300 New Results

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Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning
Alex Fogli Iseppe, Haibo Ni, Sicheng Zhu, Xianwei Zhang, Raffaele Coppini, Pei-Chi Yang, Uma Srivatsa, Colleen E. Clancy, Andrew G. Edwards, Stefano Morotti, Eleonora Grandi

bioRxiv 2020.10.26.352740; doi: https://doi.org/10.1101/2020.10.26.352740 New Results

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Targeting influenza at the topologically conserved substructures
BHUVANESWARI KAKUNURI

bioRxiv 2020.10.25.351643; doi: https://doi.org/10.1101/2020.10.25.351643 New Results

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The anti-mycobacterial activity of Artemisia annua L is based on deoxyartemisinin and artemisinic acid
Sumana Bhowmick, Rafael Baptista, David Fazakerley, Kezia E. Whatley, Karl F. Hoffmann, Jianying Shen, Luis A. J. Mur

bioRxiv 2020.10.23.352500; doi: https://doi.org/10.1101/2020.10.23.352500 New Results

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Ivermectin repurposing for COVID-19 therapy: Safety and pharmacokinetic assessment of a novel nasal spray formulation in a pig model
J. Errecalde, A. Lifschitz, G. Vecchioli, L. Ceballos, F. Errecalde, M. Ballent, G. Marín, M. Daniele, E. Turic, E. Spitzer, F. Toneguzzo, S. Gold, A. Krolewiecki, L. Alvarez, C. Lanusse

bioRxiv 2020.10.23.352831; doi: https://doi.org/10.1101/2020.10.23.352831 New Results

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Cannabis sativa Terpenes are Cannabimimetic and Provide Support for the Entourage Effect Hypothesis
Justin E. LaVigne, Ryan Hecksel, Attila Keresztes, John M. Streicher

bioRxiv 2020.10.22.350868; doi: https://doi.org/10.1101/2020.10.22.350868 New Results

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Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor
Giuseppe Deganutti, Kerry Barkan, Barbara Preti, Michele Leuenberger, Mark Wall, Bruno Frenguelli, Martin Lochner, Graham Ladds, Christopher A Reynolds

bioRxiv 2020.10.22.350827; doi: https://doi.org/10.1101/2020.10.22.350827 New Results

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Pharmacology and Toxicology

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