Pharmacology and Toxicology

Inhibition of PDE4 by Roflumilast ameliorates sleep deprivation-induced cognitive dysfunction in C57BL/6J mice
Abid Bhat, Muhammed Bishir, SR. Pandi-Perumal, Sulie Chang, Saravana B. Chidambaram

bioRxiv 2021.11.28.470251; doi: https://doi.org/10.1101/2021.11.28.470251 New Results

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Dual Effects of Nanoviricides Platform Technology Based NV-CoV-2 Biomimetic Polymer Against COVID-19
Anil Diwan, Ashok Chakraborty, Vijetha Chiniga, Vinod Arora, Preetam Holkar, Yogesh Thakur, Jay Tatake, Randall Barton, Neelam Holkar, Bethany Pond

bioRxiv 2021.11.24.469813; doi: https://doi.org/10.1101/2021.11.24.469813 New Results

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Non-Invasive Skin Sampling Detects Systemically Administered Drugs in Humans
Morgan Panitchpakdi, Kelly C. Weldon, Alan K. Jarmusch, Emily C. Gentry, Arianna Choi, Yadira Sepulveda, Shaden Aguirre, Kunyang Sun, Jeremiah D. Momper, Pieter C. Dorrestein, Shirley M. Tsunoda

bioRxiv 2021.11.22.469638; doi: https://doi.org/10.1101/2021.11.22.469638 New Results

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Atazanavir is a competitive inhibitor of SARS-CoV-2 M^pro, impairing variants replication in vitro and in vivo
Otávio Augusto Chaves, Carolina Q. Sacramento, André C. Ferreira, Mayara Mattos, Natalia Fintelman-Rodrigues, Jairo R. Temerozo, Douglas Pereira Pinto, Gabriel P. E. da Silveira, Laís Bastos da Fonseca, Heliana Martins Pereira, Aluana Santana Carlos, Joana da Costa Pinto d’Ávila, João P.B. Viola, Robson Q. Monteiro, Leonardo Vazquez, Patrícia T. Bozza, Hugo Caire Castro-Faria-Neto, Thiago Moreno L. Souza

bioRxiv 2021.11.24.469775; doi: https://doi.org/10.1101/2021.11.24.469775 New Results

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F₁F₀ ATP Hydrolysis is a Determinant of Metabolic Rate, a Correlate of Lifespan, and a Weakness of Cancer
Michael David Forrest

bioRxiv 2021.10.28.466310; doi: https://doi.org/10.1101/2021.10.28.466310 New Results

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Contractile force of transplanted cardiomyocytes contributes to heart function after injury
Tim Stüdemann, Judith Rössinger, Christoph Manthey, Birgit Geertz, Rajiven Srikantharajah, Constantin von Bibra, Aya Shibamiya, Maria Köhne, Antonius Wiehler, J. Simon Wiegert, Thomas Eschenhagen, Florian Weinberger

bioRxiv 2021.11.23.469715; doi: https://doi.org/10.1101/2021.11.23.469715 New Results

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Isolation and characterisation of quercitrin as a potent anti-sickle cell anaemia agent from Alchornea cordifolia
Olayemi Adeniyi, Rafael Baptista, Sumana Bhowmick, Alan Cookson, Robert Nash, Ana Winters, Luis A. J. Mur

bioRxiv 2021.11.11.468287; doi: https://doi.org/10.1101/2021.11.11.468287 New Results

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Hypertonic saline and aprotinin based blockage of SARS-CoV-2 specific furin site cleavage by inhibition of nasal protease activity
Clarissa Li, Adam W. Li

bioRxiv 2021.11.19.469276; doi: https://doi.org/10.1101/2021.11.19.469276 New Results

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Characterization of Reactive Oxygen Species Signaling changes in a cell culture model of skeletal muscle ageing, and its application to screening pharmacokinetically-relevant exposures of dietary polyphenols for bioactivity
N. Hayes, M. Fogarty, L. Sadofsky, H.S. Jones

bioRxiv 2021.11.20.469396; doi: https://doi.org/10.1101/2021.11.20.469396 New Results

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Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation
Shouhao Zhou, Xinyi Liu, Xinying Fang, Vernon M. Chinchilli, Michael Wang, Hong-Gang Wang, Nikolay V Dokholyan, Chan Shen, J Jack Lee

bioRxiv 2021.11.20.469388; doi: https://doi.org/10.1101/2021.11.20.469388 New Results

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Pharmacology and Toxicology

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