Pharmacology and Toxicology

Kinetic characteristics of propofol-induced inhibition of electron-transfer chain and fatty acid oxidation in human and rodent skeletal and cardiac muscles
Tomáš Urban, Petr Waldauf, Adéla Krajčová, Kateřina Jiroutková, Milada Halačová, Valér Džupa, Libor Janoušek, Eva Pokorná, František Duška

bioRxiv 633156; doi: https://doi.org/10.1101/633156 New Results
An investigation of PS-b-PEO polymersomes for the oral treatment and diagnosis of hyperammonemia
Simon Matoori, Yinyin Bao, Aaron Schmidt, Eric J. Fischer, Rafael Ochoa-Sanchez, Mélanie Tremblay, Mariana Oliveira, Christopher F. Rose, Jean-Christophe Leroux

bioRxiv 631630; doi: https://doi.org/10.1101/631630 New Results
Development of SGC-GAK-1 as an orally active in vivo probe for cyclin G associated kinase through cytochrome P450 inhibition
Christopher R. M. Asquith, James M. Bennett, Lianyong Su, Tuomo Laitinen, Jonathan M. Elkins, Julie E. Pickett, Carrow I. Wells, Zengbiao Li, Timothy M. Willson, William J. Zuercher

bioRxiv 629220; doi: https://doi.org/10.1101/629220 New Results
Developmental exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) selectively decreases brain dopamine levels in northern leopard frogs
Rachel M. Foguth, R. Wesley Flynn, Chloe de Perre, Michael Iacchetta, Linda S. Lee, Maria S. Sepúlveda, Jason R. Cannon

bioRxiv 623900; doi: https://doi.org/10.1101/623900 New Results
Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo
Stephanie Kim, Nabil Rabhi, Benjamin C. Blum, Ryan Hekman, Kieran Wynne, Andrew Emili, Stephen Farmer, Jennifer J. Schlezinger

bioRxiv 626390; doi: https://doi.org/10.1101/626390 New Results
Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG
Sangeetha Iyer, Kausalya Murthy, Zachary Parton, Hillary Tsang, Feba S. Sam, Nina DiPrimio, Jessica Lao, Ethan O. Perlstein

bioRxiv 626697; doi: https://doi.org/10.1101/626697 New Results
Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Jihong Li, Yoshiyuki Fukase, Yi Shang, Wei Zou, José M. Muñoz-Félix, Lorena Buitrago, Johannes van Agthoven, Yixiao Zhang, Ryoma Hara, Yuta Tanaka, Rei Okamoto, Takeshi Yasui, Takashi Nakahata, Toshihiro Imaeda, Kazuyoshi Aso, Yuchen Zhou, Charles Locuson, Dragana Nesic, Mark Duggan, Junichi Takagi, Roger Vaughan, Thomas Walz, Kairbaan Hodivala-Dilke, Steven Teitelbaum, M. Amin Arnaout, Marta Filizola, Michael Foley, Barry S. Coller

bioRxiv 620765; doi: https://doi.org/10.1101/620765 New Results
Pharmacodynamics of linezolid-plus-fosfomycin against vancomycin-susceptible and -resistant enterococci in vitro and in vivo of a Galleria mellonella larval infection model
Caifen Qi, Shuangli Xu, Maomao Wu, Shuo Zhu, Yanyan Liu, Hong Huang, Guijun Zhang, Jiabin Li, Xiaohui Huang

bioRxiv 624577; doi: https://doi.org/10.1101/624577 New Results
Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance
Doyoung Kwon, Sung-Mi Kim, Peyton Jacob 3rd, Yi Liu, Maria Almira Correia

bioRxiv 623041; doi: https://doi.org/10.1101/623041 New Results
Tetrahydrocannabinolic Acid a (THCA-A) Reduces Adiposity and Prevents Metabolic Disease Caused by Diet-Induced Obesity
Belén Palomares, Francisco Ruiz-Pino, Martin Garrido-Rodriguez, M. Eugenia Prados, Miguel A. Sánchez-Garrido, Inmaculada Velasco, María J. Vazquez, Xavier Nadal, Carlos Ferreiro-Vera, Rosario Morrugares, Giovanni Appendino, Gaetano Morello, Marco A Calzado, Manuel Tena-Sempere, Eduardo Muñoz

bioRxiv 622035; doi: https://doi.org/10.1101/622035 New Results

Pharmacology and Toxicology

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