Pharmacology and Toxicology

Identification of differential polypharmacology between the PARP inhibitor rucaparib and its major metabolite
Huabin Hu, Carme Serra, Amadeu Llebaria, Albert A. Antolin

bioRxiv 2022.11.22.517505; doi: https://doi.org/10.1101/2022.11.22.517505 New Results

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Amyloid Beta Peptides Inhibit Glucose Transport at the Blood-brain Barrier by Disrupting Insulin-Akt Pathway in Alzheimer’s Disease
Lushan Wang, Geoffry L. Curran, Paul H. Min, Ling Li, Val J. Lowe, Karunya K. Kandimalla

bioRxiv 2022.11.21.517280; doi: https://doi.org/10.1101/2022.11.21.517280 New Results

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Evaluation of the reliability and applicability of human unbound brain-to-plasma concentration ratios
Urban Fagerholm

bioRxiv 2022.11.14.516429; doi: https://doi.org/10.1101/2022.11.14.516429 New Results

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Differential effects of cobalt ions in vitro on gill (Na⁺, K⁺)-ATPase kinetics in the blue crab Callinectes danae (Decapoda, Brachyura)
Francisco A. Leone, Leonardo M. Fabri, Maria I. C. Costa, Cintya M. Moraes, Daniela P. Garçon, John C. McNamara

bioRxiv 2022.11.18.516930; doi: https://doi.org/10.1101/2022.11.18.516930 New Results

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Fragment Linker Prediction Using Deep Encoder-Decoder Network for PROTAC Drug Design
Chien-Ting Kao, Chieh-Te Lin, Cheng-Li Chou, Chu-Chung Lin

bioRxiv 2022.11.17.516992; doi: https://doi.org/10.1101/2022.11.17.516992 New Results

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Pyruvate-conjugation of PEGylated liposomes effectively enhances their uptake in retinal photoreceptors
Gustav Christensen, Yiyi Chen, Dileep Urimi, Nicolaas Schipper, François Paquet-Durand

bioRxiv 2022.11.18.517040; doi: https://doi.org/10.1101/2022.11.18.517040 New Results

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Deconvolution of plasma pharmacokinetics from dynamic heart imaging data obtained by SPECT/CT imaging
Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe, Karunya K. Kandimalla

bioRxiv 2022.11.17.517003; doi: https://doi.org/10.1101/2022.11.17.517003 New Results

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Adult consequences of repeated nicotine vapor inhalation in adolescent rats
Arnold Gutierrez, Jacques D. Nguyen, Kevin M. Creehan, Yanabel Grant, Michael A. Taffe

bioRxiv 2022.11.17.516984; doi: https://doi.org/10.1101/2022.11.17.516984 New Results

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Elimination of Foxo triplets following glucocorticoid incubation dampened metabolic stress and enhanced anti-viral response targets based on transcriptomic analysis
Prasanth Puthanveetil, Daniel Rafferty, Boyi Gan, Charlotte A. Bolch

bioRxiv 2022.11.17.517006; doi: https://doi.org/10.1101/2022.11.17.517006 New Results

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Holistic profiling of the venom from the lethal spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics
FC Cardoso, AA Walker, GF King, MV Gomez

bioRxiv 2022.11.17.516848; doi: https://doi.org/10.1101/2022.11.17.516848 New Results

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Pharmacology and Toxicology

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