Pharmacology and Toxicology

Increased Cerebral Blood Flow after single dose of antipsychotics in healthy volunteers depends on dopamine D2 receptor density profiles.
Pierluigi Selvaggi, Peter CT Hawkins, Ottavia Dipasquale, Gaia Rizzo, Alessandro Bertolino, Juergen Dukart, Fabio Sambataro, Giulio Pergola, Steven CR Williams, Federico E Turkheimer, Fernando Zelaya, Mattia Veronese, Mitul A Mehta

bioRxiv 336933; doi: https://doi.org/10.1101/336933 New Results
Evaluation of the cytotoxic potential of extracts from the genus Passiflora cultived in Brazil against cancer cells
Ricardo Guimarães Amaral, Silvana Vieira Floresta Gomes, Ângelo Roberto Antoniolli, Maria Claudia dos Santos Luciano, Cláudia do Ó Pessoa, Luciana Nalone Andrade, Patrícia NALONE Severino, Geraldo Célio Brandão, Larissa Mendes Bomfim, Daniel Pereira Bezerra, Jorge Maurício David, Adriana Andrade Carvalho

bioRxiv 337253; doi: https://doi.org/10.1101/337253 New Results
Xanthine urolithiasis: Inhibitors of xanthine crystallization
Felix Grases, Antonia Costa-Bauza, Joan Roig, Adrian Rodriguez

bioRxiv 335364; doi: https://doi.org/10.1101/335364 New Results
Tox_(R)CNN: Deep Learning-Based Nuclei Profiling tool For Drug Toxicity Screening
Daniel Jimenez-Carretero, Vahid Abrishami, Laura Fernandez-de-Manuel, Irene Palacios, Antonio Quilez-Alvarez, Alberto Diez-Sanchez, Miguel Angel del Pozo, María Concepcion Montoya

bioRxiv 334557; doi: https://doi.org/10.1101/334557 New Results
Potential combined pro-cognitive, anxiolytic and antidepressant properties of novel GABAA receptor positive modulators with preferential efficacy at the α5-subunit
Thomas D. Prevot, Guanguan Li, Aleksandra Vidojevic, Keith A. Misquitta, Corey Fee, Anja Santrac, Daniel E Knutson, Michael R Stephen, Revathi Kodali, Nicolas M Zahn, Leggy Arnold, Petra Scholze, Janet L Fisher, Bojan D. Markovic, Mounira Banasr, James M Cook, Miroslav Savic, Etienne Sibille

bioRxiv 332908; doi: https://doi.org/10.1101/332908 New Results
Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling
Julie A Simpson, James McCaw, Pengxing Cao, Freya J.I. Fowkes, Sophie Zaloumis, Ric N Price, Saber Dini

bioRxiv 331850; doi: https://doi.org/10.1101/331850 New Results
The QNOAEL vs. BMD for Point of Departure
Cynthia Dickerson, Robert A. Lodder

bioRxiv 329763; doi: https://doi.org/10.1101/329763 New Results
Predicting Response to Platin Chemotherapy Agents with Biochemically-inspired Machine Learning
Eliseos J Mucaki, Jonathan Z.L Zhao, Dan Lizotte, Peter K Rogan

bioRxiv 231712; doi: https://doi.org/10.1101/231712 New Results
Piperazine-based HIV-1 entry inhibitors: Massive in silico library design and screening for gp120 attachment inhibitors.
Durbis Javier Castillo-Pazos, Ruben Antonio Romo-Mancillas, Joaquín Barroso-Flores

bioRxiv 330142; doi: https://doi.org/10.1101/330142 New Results
Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models
Stephanie M Kim, Amy Li, Stefano Monti, Jennifer J Schlezinger

bioRxiv 328203; doi: https://doi.org/10.1101/328203 New Results

Pharmacology and Toxicology

Pages