Pharmacology and Toxicology

All-optical electrophysiology refines populations of in silico human iPS-CMs for drug evaluation
M Paci, E Passini, A Klimas, S Severi, J Hyttinen, B Rodriguez, E Entcheva

bioRxiv 799478; doi: https://doi.org/10.1101/799478 New Results

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Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3
RE Akhigbe, A.F Ajayi

bioRxiv 796110; doi: https://doi.org/10.1101/796110 New Results

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Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release
Masayuki Akatsuka, Yoshiki Masuda, Hiroomi Tatsumi, Michiaki Yamakage

bioRxiv 780403; doi: https://doi.org/10.1101/780403 New Results

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Widespread dysregulation of long non-coding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed rat liver
Kritika Karri, David J. Waxman

bioRxiv 791772; doi: https://doi.org/10.1101/791772 New Results

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N-Acetyl Cysteine Abrogates Silver-Induced Reactive Oxygen Species in Human Cells Without Altering Silver-based Antimicrobial Activity
Kush N. Shah, Parth N. Shah, Andrew R. Mullen, Qingquan Chen, Ralph J. DeBerardinis, Carolyn L. Cannon

bioRxiv 792150; doi: https://doi.org/10.1101/792150 New Results

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Deposition of Polycyclic Aromatic Hydrocarbons (PAHs) into Northern Ontario Lake Sediments
Graham A. Colby

bioRxiv 786913; doi: https://doi.org/10.1101/786913 New Results

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Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2
Senem Merve Fred, Liina Laukkanen, Cecilia A Brunello, Liisa Vesa, Helka Goos, Iseline Cardon, Rafael Moliner, Tanja Maritzen, Markku Varjosalo, Plinio C Casarotto, Eero Castrén

bioRxiv 591909; doi: https://doi.org/10.1101/591909 New Results

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Development of a simple method for differential delivery of volatile anaesthetics to the spinal cord of the rabbit
Peng Zhang, Yao Li, Ting Xu

bioRxiv 785253; doi: https://doi.org/10.1101/785253 New Results

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Clinical evaluation of postoperative analgesia and serum biochemical changes of paracetamol compared to meloxicam and carprofen in bitches undergoing ovariohysterectomy
Ismael Hernández-Avalos, Alexander Valverde, José Antonio Ibancovichi-Camarillo, Pedro Sánchez-Aparicio, Sergio Recillas-Morales, Jorge Osorio-Avalos, Desiderio Rodríguez-Velázquez, Agatha Elisa Miranda-Cortés

bioRxiv 785246; doi: https://doi.org/10.1101/785246 New Results

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Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology
Robert Ietswaart, Seda Arat, Amanda X. Chen, Saman Farahmand, Bumjun Kim, William DuMouchel, Duncan Armstrong, Alexander Fekete, Jeffrey J. Sutherland, Laszlo Urban

bioRxiv 750950; doi: https://doi.org/10.1101/750950 New Results

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Pharmacology and Toxicology

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