Pharmacology and Toxicology

In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids
Shivani Sachdev, Kiran Vemuri, Samuel D. Banister, Mitchell Longworth, Michael Kassiou, Marina Santiago, Alexandros Makriyannis, Mark Connor

bioRxiv 385583; doi: https://doi.org/10.1101/385583

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Predicting Response to Platin Chemotherapy Agents with Biochemically-inspired Machine Learning
Eliseos J. Mucaki, Jonathan Z.L. Zhao, Dan Lizotte, Peter K. Rogan

bioRxiv 231712; doi: https://doi.org/10.1101/231712

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A standardised framework to identify optimal animal models for efficacy assessment in drug development
Guilherme S. Ferreira (PhD Candidate), Désirée Veening-Griffioen (PhD Candidate), Wouter Boon (Assistant Professor), Ellen Moors (Professor), Christine Gispen-de Wied (Scientific Staff), Huub Schellekens (Professor), Peter van Meer (Postdoctoral Researcher Non-Clinical Assessor)

bioRxiv 382366; doi: https://doi.org/10.1101/382366

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In silico prioritization of transporter-drug relationships from drug sensitivity screens
A. César-Razquin, E. Girardi, M. Yang, M. Brehme, J. Sáez-Rodríguez, G. Superti-Furga

bioRxiv 381335; doi: https://doi.org/10.1101/381335

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Predicting Negative Control Drugs to Support Research in Drug Safety
Yun Hao, Nicholas P. Tatonetti

bioRxiv 380832; doi: https://doi.org/10.1101/380832

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Development and Application of a High-Content Virion Display Human GPCR Array
Guan-Da Syu, Shih-Chin Wang, Guangzhong Ma, Shuang Liu, Donna Pearce, Atish Prakash, Brandon Henson, Lien-Chun Weng, Devlina Ghosh, Pedro Ramos, Daniel Eichinger, Ignacio Pino, Xinzhong Dong, Jie Xiao, Shaopeng Wang, Nongjian Tao, Kwang Sik Kim, Prashant J. Desai, Heng Zhu

bioRxiv 377754; doi: https://doi.org/10.1101/377754

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Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes in Mice
Anish Engineer, Tana Saiyin, Xiangru Lu, Andrew S. Kucey, Brad L. Urquhart, Thomas A. Drysdale, Kambiz Norozi, Qingping Feng

bioRxiv 304006; doi: https://doi.org/10.1101/304006

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Development of an imaging toolbox to assess the therapeutic potential and biodistribution of macrophages in a mouse model of multiple organ dysfunction
Jack Sharkey, Lorenzo Ressel, Nathalie Brillant, Bettina Wilm, B. Kevin Park, Patricia Murray

bioRxiv 372482; doi: https://doi.org/10.1101/372482

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Apigenin relaxes rat intrarenal arteries: involvement of Cl⁻ channels and K⁺ channels
Yixin Jing, Miaomiao Dong, Yu Liu, Xiaomin Hou, Pengmei Guo, Weiping Li, Mingsheng Zhang, Jiyuan Lv

bioRxiv 371849; doi: https://doi.org/10.1101/371849

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Costing ‘the’ MTD … in 2-D
David C. Norris

bioRxiv 370817; doi: https://doi.org/10.1101/370817

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Pharmacology and Toxicology

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