Pharmacology and Toxicology

In vitro activity of imipenem/relebactam alone and in combination against cystic fibrosis isolates of Mycobacterium abscessus
Madeline Sanders, Sun Woo Kim, Aditi Shinde, Danielle Fletcher-Williams, Eric Quach, Paul Beringer

bioRxiv 2024.12.10.627836; doi: https://doi.org/10.1101/2024.12.10.627836 New Results

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Effects of the muscarinic M1 agonist VU0364572 and the M1/M4-prefering agonist xanomeline on cocaine choice in male and female rats
Samuel A. Marsh, Nicholas Heslep, S. Stevens Negus, Matthew L. Banks

bioRxiv 2025.03.03.641295; doi: https://doi.org/10.1101/2025.03.03.641295 Confirmatory Results

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Phytochemicals and Antioxidant Activity of Leaf Extract and Callus Cultures of Cinnamomum camphora L
Sajal Rasool, Sheza Ayaz Khilji, Zahoor Ahmad Sajid

bioRxiv 2025.03.04.641517; doi: https://doi.org/10.1101/2025.03.04.641517 New Results

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Multi-Coloured Sequential Resonance Energy Transfer for Simultaneous Ligand Binding at G Protein-Coupled Receptors
Alice Valentini, Bethany Dibnah, Marija Ciba, Elaine M. Duncan, Asmita Manandhar, Bethany Strellis, Luca Vita, Olivia Lucianno, Conor Massey, Sophie Coe, Trond Ulven, Brian D. Hudson, Elisabeth Rexen Ulven

bioRxiv 2024.08.07.606978; doi: https://doi.org/10.1101/2024.08.07.606978 New Results

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Optimization and evaluation of complementary degrader discovery assays for application in screening
Johanna Huchting, Arjen Weller, Moyra Schweizer, Mona Brandt, Jan Heering, Maria Kuzikov, Markus Wolf, Jeanette Reinshagen, Markus A. Queisser, Philip Gribbon, Andrea Zaliani, Ole Pless, Aimo Kannt

bioRxiv 2025.03.06.641606; doi: https://doi.org/10.1101/2025.03.06.641606 New Results

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Assessment of high-efficacy agonism in synthetic cannabinoid receptor agonists containing l-tert-leucinate
Christopher Lucaj, Charlotte Pitha, Jordan Davis, Hideaki Yano

bioRxiv 2024.10.11.617959; doi: https://doi.org/10.1101/2024.10.11.617959 New Results

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On the Comparability of Studies in Predictive Ecotoxicology
Christoph Schür, Kristin Schirmer, Marco Baity-Jesi

bioRxiv 2025.03.04.641385; doi: https://doi.org/10.1101/2025.03.04.641385 New Results

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Identification of Direct-acting nsP2 Helicase Inhibitors with Antialphaviral Activity
Muthu Ramalingam Bose, John D. Sears, Kacey M. Talbot, Yuan-Wei Norman Su, Scott Houliston, Mohammed Anwar Hossain, Zachary W. Davis-Gilbert, Chunqing Zhao, Hans J. Oh, Peter J. Brown, Marcia K. Sanders, Stella R. Moorman, Durbadal Ojha, Jane E. Burdick, Isabella Law, Noah L. Morales, Sabian A. Martinez, Peter Loppnau, Julia Garcia Perez, Adam M. Drobish, Thomas E. Morrison, Zachary J. Streblow, Daniel N. Streblow, Cheryl H. Arrowsmith, Ava Vargason, Rafael M. Couñago, Levon Halabelian, Jamie J. Arnold, Craig E. Cameron, Nathaniel J. Moorman, Mark T. Heise, Timothy M. Willson

bioRxiv 2025.03.04.641060; doi: https://doi.org/10.1101/2025.03.04.641060 New Results

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Aetokthonotoxin, the causative agent of vacuolar myelinopathy, uncouples oxidative phosphorylation due to protonophore activity
Valerie I. C. Rebhahn, Mohamad Saoud, Mathias Winterhalter, Franziska Schanbacher, Maximilian Jobst, Rebeca Ruiz, Alexander Sonntag, Johannes Kollatz, Rieke Sprengel, Stephen F. Donovan, Giorgia Del Favero, Robert Rennert, Timo H. J. Niedermeyer

bioRxiv 2025.03.04.637646; doi: https://doi.org/10.1101/2025.03.04.637646 New Results

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Identification of Rapaglutin E as An Isoform-specific Inhibitor of Glucose Transporter 1
Marnie Kotlyar, Zufeng Guo, A.V. Subba Rao, Hanjing Peng, Jingxin Wang, Zhongnan Ma, Cordelia Schiene-Fischer, Gunter Fischer, Jun O. Liu

bioRxiv 2025.03.02.641094; doi: https://doi.org/10.1101/2025.03.02.641094 New Results

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Pharmacology and Toxicology

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