Pharmacology and Toxicology

Drug repurposing: omeprazole increases the efficacy of acyclovir against herpes simplex virus type 1 and 2
Martin Michaelis, Malte C Kleinschmidt, Mark N Wass, Jindrich Cinatl Jr.

bioRxiv 313072; doi: https://doi.org/10.1101/313072 New Results
Population Pharmacokinetics Study of Morinidazole in Patients with Moderate Hepatic Impairment
Yue Kang, Fengyan Xu, Kun Wang, Jing Zhang, Xiao-jie Wu, Jufang Wu, Guo-ying Cao, Jicheng Yu, Bei-ning Guo, Yuan-cheng Chen, Ying-yuan Zhang

bioRxiv 312728; doi: https://doi.org/10.1101/312728 New Results
The Biological Evaluation of Fusidic Acid and Its Hydrogenation Derivative as Antimicrobial and Anti-inflammatory Agents
Panpan Wu, Hao He, W. David Hong, Tongrong Wu, Suqing Zhao, Xiping Cui, Yingying Zhong, Dongli Li, Xuetao Xu, Zhaojun Sheng, Borong Tu, Min Gao, Jun Zhou, Stephen Ward, Paul M. O'Neill, Kun Zhang

bioRxiv 311951; doi: https://doi.org/10.1101/311951 New Results
The utility of Saw-scaled viper, Echis pyramidum, and Kenyan sand boa, Eryx colubrinus as bioindicator of heavy metals bioaccumulation in relation to DPTA soil extract and biological consequences.
Doha Magdy Mostafa Sleem, Mohamed Adel Mohamed Kadry, Eman Mahmoud Ezzat Mohallal, Mohamed Assem Marie

bioRxiv 311357; doi: https://doi.org/10.1101/311357 New Results
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm
Frederick A Partridge, Ruth Forman, Nicky J Willis, Carole JR Bataille, Emma A Murphy, Anwen E Brown, Narinder Heyer-Chauhan, Bruno Marinič, Daniel JC Sowood, Graham M Wynne, Kathryn J Else, Angela J Russell, David B Sattelle

bioRxiv 254037; doi: https://doi.org/10.1101/254037 New Results
iPSC-derived neurons as a tool for probing molecular pharmacology of antipsychotic action.
Esther S Kim, E. David Leonardo, Alex Dranovsky

bioRxiv 308486; doi: https://doi.org/10.1101/308486 New Results
Identification and Quantification of Paclitaxel and its Metabolites in Human Meconium from Newborns with Gestational Chemotherapeutic Exposure
Elyce Cardonick, Robert Broadrup, Peining Xu, Mary T. Doan, Helen Jiang, Nathaniel Snyder

bioRxiv 306274; doi: https://doi.org/10.1101/306274 New Results
Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes in Mice
Anish Engineer, Tana Saiyin, Xiangru Lu, Andrew S. Kucey, Brad L. Urquhart, Thomas A. Drysdale, Kambiz Norozi, Qingping Feng

bioRxiv 304006; doi: https://doi.org/10.1101/304006 New Results
Azithromycin reduces systemic inflammation and provides survival benefit in murine model of polymicrobial sepsis
Anasuya Patel, Jiji Joseph, Hariharan Periasamy, Santosh Mokale

bioRxiv 303610; doi: https://doi.org/10.1101/303610 Confirmatory Results
Early Exposure to Polycyclic Aromatic Hydrocarbons (PAHs) and Cardiac Toxicity in a Species (Xenopus laevis) with Low Aryl Hydrocarbon Receptor (AHR) Responsiveness
Madison C Sestak, Julia A Pinette, Caithlin M Lamoureux, Susan L Whittemore

bioRxiv 301846; doi: https://doi.org/10.1101/301846 New Results

Pharmacology and Toxicology

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