Pharmacology and Toxicology

In vitro efficacy of Artemisinin-based treatments against SARS-CoV-2
Kerry Gilmore, Yuyong Zhou, Santseharay Ramirez, Long V. Pham, Ulrik Fahnøe, Shan Feng, Anna Offersgaard, Jakob Trimpert, Jens Bukh, Klaus Osterrieder, Judith M. Gottwein, Peter H. Seeberger

bioRxiv 2020.10.05.326637; doi: https://doi.org/10.1101/2020.10.05.326637

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A vapor exposure method for delivering heroin alters nociception, body temperature and spontaneous activity in female and male rats
Arnold Gutierrez, Kevin M. Creehan, Michael A. Taffe

bioRxiv 2020.09.03.281857; doi: https://doi.org/10.1101/2020.09.03.281857

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Negative controls of chemical probes can be misleading
Jinyoung Lee, Matthieu Schapira

bioRxiv 2020.09.30.320465; doi: https://doi.org/10.1101/2020.09.30.320465

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Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway
Laura Marroqui, Juan Martinez-Pinna, Manuel Castellano-Muñoz, Reinaldo S. dos Santos, Regla M. Medina-Gali, Sergi Soriano, Ivan Quesada, Jan-Ake Gustafsson, José A. Encinar, Angel Nadal

bioRxiv 2020.09.30.319988; doi: https://doi.org/10.1101/2020.09.30.319988

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Silencing NADPH-Cytochrome P450 reductase affects imidacloprid susceptibility, fecundity, and embryonic development in Leptinotarsa decemlineata
Timothy W. Moural, Liping Ban, Jonathan A. Hernandez, Meixiang Wu, Chaoyang Zhao, Subba R. Palli, Andrei Alyokhin, Fang Zhu

bioRxiv 2020.09.29.318634; doi: https://doi.org/10.1101/2020.09.29.318634

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A small-molecule oral agonist of the human glucagon-like peptide-1 receptor
David A. Griffith, David J. Edmonds, Jean-Phillipe Fortin, Amit S. Kalgutkar, J. Brent Kuzmiski, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Clare Buckeridge, John M. Curto, David R. Derksen, João M. Dias, Matthew C. Griffor, Seungil Han, V. Margaret Jackson, Margaret S. Landis, Daniel J. Lettiere, Chris Limberakis, Yuhang Liu, Alan M. Mathiowetz, David W. Piotrowski, David A. Price, Roger B. Ruggeri, David A. Tess

bioRxiv 2020.09.29.319483; doi: https://doi.org/10.1101/2020.09.29.319483

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Active fatty acid oxidation defines the cellular response towards reactive oxygen species
Lars Kaiser, Isabel Quint, René Csuk, Manfred Jung, Hans-Peter Deigner

bioRxiv 2020.07.13.200022; doi: https://doi.org/10.1101/2020.07.13.200022

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Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids
Ezgi Oner, Mustafa Kotmakci, Anne-Marie Baird, Steven G. Gray, Bilge Debelec Butuner, Emir Bozkurt, Ayse Gulten Kantarci, Stephen P. Finn

bioRxiv 2020.09.28.315341; doi: https://doi.org/10.1101/2020.09.28.315341

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Glutamic acid promotes hair growth in mice
Carlos Poblete Jara, Beatriz de Andrade Berti, Natalia Ferreira Mendes, Daiane F. Engel, Ariane Maria Zanesco, Gabriela Freitas Souza, Lício Augusto Velloso, Eliana Pereira de Araujo

bioRxiv 2020.09.27.315523; doi: https://doi.org/10.1101/2020.09.27.315523

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Improving drug safety predictions by reducing poor analytical practices
Stanley E. Lazic, Dominic P. Williams

bioRxiv 2020.09.25.314138; doi: https://doi.org/10.1101/2020.09.25.314138

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Pharmacology and Toxicology

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