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Pharmacology and Toxicology

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  • In vivo and in silico experiment on Mitragyna speciosa offers new insight of antidiabetic potentials
    Mohammad Uzzal Hossain, Md. Shahadat Hossain, Shajib Dey, A.B.Z. Naimur Rahman, Zeshan Mahmud Chowdhury, Arittra Bhattacharjee, Ishtiaque Ahammad, Md. Nazrul Islam, Md. Moniruzzaman, Md. Billal Hosen, Istiak Ahmed, Keshob Chandra Das, Chaman Ara Keya, Md. Salimullah
    bioRxiv 2023.11.08.566341; doi: https://doi.org/10.1101/2023.11.08.566341 New Results
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  • In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish
    Ethan Bustad, Emma Mudrock, Elizabeth M. Nilles, Andrea McQuate, Monica Bergado, Alden Gu, Louie Galitan, Natalie Gleason, Henry C. Ou, David W. Raible, Rafael E. Hernandez, Shuyi Ma
    bioRxiv 2023.11.08.566159; doi: https://doi.org/10.1101/2023.11.08.566159 New Results
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  • Insights into the early-life chemical exposome of Nigerian infants and potential correlations with the developing gut microbiome
    Ian Oesterle, Kolawole I. Ayeni, Chibundu N. Ezekiel, David Berry, Annette Rompel, Benedikt Warth
    bioRxiv 2023.11.08.566030; doi: https://doi.org/10.1101/2023.11.08.566030 New Results
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  • Use of Multiple Pharmacodynamic Measures to Deconstruct the Nix-TB Regimen in a Short-Course Murine Model of Tuberculosis
    M.A. Lyons, A. Obregon-Henao, M.E. Ramey, A.A. Bauman, S. Pauly, K. Rossmassler, J. Reid, B. Karger, N.D. Walter, G.T. Robertson
    bioRxiv 2023.11.08.566205; doi: https://doi.org/10.1101/2023.11.08.566205 New Results
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  • Characterization of Gαs and Gαolf activation by catechol and non-catechol dopamine D1 receptor agonists
    Anh Minh Nguyen, Ana Semeano, Vianna Quach, Asuka Inoue, David E. Nichols, Hideaki Yano
    bioRxiv 2023.10.03.560682; doi: https://doi.org/10.1101/2023.10.03.560682 New Results
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  • Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out
    Danny Wilbie, Selma Eising, Vicky Amo-Addae, Johanna Walther, Esmeralda Bosman, Olivier G de Jong, Jan J Molenaar, Enrico Mastrobattista
    bioRxiv 2023.11.09.566375; doi: https://doi.org/10.1101/2023.11.09.566375 New Results
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  • Antiproliferative Activity of Cephalotaxus Esters: Overcoming Chemoresistance in Cancer Therapy
    Vladimir Yong-Gonzalez, Constantine Radu, Paul A. Calder, David Shum, David Y. Gin, Mark G. Frattini, Hakim Djaballah
    bioRxiv 2023.11.06.565820; doi: https://doi.org/10.1101/2023.11.06.565820 New Results
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  • Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
    Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J. Bouchonville, Amy S. Etheridge, Remington E. Schmidt, Brianna M. Bembenek, Zoey B. Temesgen, Zhiquan Wang, Federico Innocenti, Deborah Stroka, Robert B. Diasio, Carlo R. Largiadèr, Steven M. Offer
    bioRxiv 2023.11.01.565230; doi: https://doi.org/10.1101/2023.11.01.565230 New Results
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  • Structural Insights into Dopamine Receptor-Ligand Interactions: From Agonists to Antagonists
    Emmanuel Barbosa, Heather Clift, Linda Olson, Lan Zhu, Wei Liu
    bioRxiv 2023.11.03.565579; doi: https://doi.org/10.1101/2023.11.03.565579 New Results
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  • Utilizing gene co-expression networks with the rat kidney TXG-MAPr tool to enhance safety assessment, biomarker identification and human translation
    Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Lukas S. Wijaya, Hugo van Kessel, Git Chung, Keith Pye, Colin Brown, Keith M. Goldstein, Claire R. Teague, Ciarán Fisher, James S. Harvey, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water
    bioRxiv 2023.11.03.565444; doi: https://doi.org/10.1101/2023.11.03.565444 New Results
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