Pharmacology and Toxicology

Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain
Andreza U. Quadros, Alexandre G. M. Maganin, Conceição E. A. Silva, Samara Damasceno, Maria C. M. Cavallini, Marcela Davoli-Ferreira, Alexandre H. P. Lopes, Devi R. Sagar, Laura Brandolini, Sang Hoon Lee, Jose C. Alves-Filho, Fernando Q. Cunha, Temugin Berta, Jörg Köhl, Marcello Allegretti, Victoria Chapman, Thiago M. Cunha

bioRxiv 2022.07.01.498487; doi: https://doi.org/10.1101/2022.07.01.498487 New Results

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Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals
Lijuan Xu, Xinyao Zhang, Yin Zhao, Yang Cao, Yuanbo Liang

bioRxiv 2022.06.30.498232; doi: https://doi.org/10.1101/2022.06.30.498232 New Results

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Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response
Yuki M. Kyunai, Mika Sakamoto, Mayuko Koreishi, Tsujino Yoshio, Ayano Satoh

bioRxiv 2022.06.30.498277; doi: https://doi.org/10.1101/2022.06.30.498277 New Results

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Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents
Erik B. Faber, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Luxin Sun, Nan Wang, Damien Rasmussen, Abir Majumdar, Kristen John, An Yang, Hira Khalid, Jon E. Hawkinson, Nicholas M. Levinson, Ernst Schönbrunn, Vargheese Chennathukuzhi, Daniel A. Harki, Gunda I. Georg

bioRxiv 2022.06.30.497818; doi: https://doi.org/10.1101/2022.06.30.497818 New Results

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Critical analysis of radical scavenging properties of atorvastatin in methanol recently estimated via density functional theory
Ioan Bâldea

bioRxiv 2022.06.28.497928; doi: https://doi.org/10.1101/2022.06.28.497928 New Results

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Phenotypic screening of the ReFrame Drug Repurposing Library to discover new drugs for treating sickle cell disease
Belhu Metaferia, Troy Cellmer, Emily B. Dunkelberger, Quan Li, Eric R. Henry, James Hofrichter, Dwayne Staton, Matthew M. Hsieh, Anna K. Conrey, John F. Tisdale, Arnab K. Chatterjee, Swee Lay Thein, William A. Eaton

bioRxiv 2022.06.23.497377; doi: https://doi.org/10.1101/2022.06.23.497377 New Results

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Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus
Sarah A. Gilmore, Danny Tam, Tara L. Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y. Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M. Brendza, Todd C. Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H. Tay, William E. Delaney IV, Gregory T. Notte, Uli Schmitz, Becket Feierbach

bioRxiv 2022.06.27.497732; doi: https://doi.org/10.1101/2022.06.27.497732 New Results

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Quantification of Receptor Binding from Response Data Obtained at Different Receptor Levels: A Simple Individual Sigmoid Fitting and a Unified SABRE Approach
Peter Buchwald

bioRxiv 2022.06.27.497811; doi: https://doi.org/10.1101/2022.06.27.497811 New Results

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A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer
Chengyao Chiang, Min Zhang, Junrong Huang, Juan Zeng, Chunlan Chen, Dongmei Pan, Heng Yang, Min Yang, Qiangqiang Han, Wang Zou, Tian Xiao, Yongdong Zou, Feng Yin, Zigang Li, Lizhi Zhu, Duo Zheng

bioRxiv 2022.06.27.497627; doi: https://doi.org/10.1101/2022.06.27.497627 New Results

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Safety and uptake of fully oxidized β-carotene
Graham W. Burton, Trevor J. Mogg, Jacek Stupak, Felicity C. Stark, Susan M. Twine, Jianjun Li

bioRxiv 2022.06.27.497750; doi: https://doi.org/10.1101/2022.06.27.497750 New Results

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Pharmacology and Toxicology

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