Pharmacology and Toxicology

Influence of gut microbiota on oral drug absorption and metabolism
Douglas Nelson, Vaishnavi Veerareddy, Purna C Kashyap, Xiaojiao Tang, Krishna R. Kalari, Karunya K. Kandimalla

bioRxiv 2025.02.16.638186; doi: https://doi.org/10.1101/2025.02.16.638186 New Results

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A mixture of endocrine disrupting chemicals linked to lower birth weight induces adipogenesis and transcriptional changes related to birth weight alterations and diabetes
Polina Lizunkova, Nicolò Caporale, Elin Engdahl, Cristina Cheroni, Pierre-Luc Germain, Gábor Borbély, Christian Lindh, Chris Gennings, Carl-Gustaf Bornehag, Giuseppe Testa, Joëlle Rüegg

bioRxiv 2025.02.13.638050; doi: https://doi.org/10.1101/2025.02.13.638050 New Results

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A single domain intrabody as a novel tool to bias the subcellular trafficking of the follicle-stimulating hormone receptor
Pauline Raynaud, Juliette Gourdon, Vinesh Jugnarain, Lucille Berthet, Frédéric Jean-Alphonse, Océane Vaugrente, Camille Gauthier, Amandine Vallet, Priyanka Anujan, Delphine Naquin, Thomas Boulo, Christophe Gauthier, Danièle Klett, Yves Combarnous, Aylin Hanyaloglu, Eric Reiter, Gilles Bruneau, Pascale Crépieux

bioRxiv 2025.02.13.638052; doi: https://doi.org/10.1101/2025.02.13.638052 New Results

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Regioselectively Acetylated Silybin Derivatives and their Cytotoxic Activity in Liver Cancer Cells
Tran Van Chien, Tran Thi Phuong Thao, Nguyen The Anh, Tran Van Loc, Michelle D. Garrett, Nguyen Thi Nga, Do Thi Thao, Christopher J. Serpell, Tran Van Sung

bioRxiv 2025.02.13.638106; doi: https://doi.org/10.1101/2025.02.13.638106 New Results

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Adult killifish exposure to crude oil perturbs embryonic gene expression and larval morphology in first- and second-generation offspring
Jane Park, Chelsea Hess, Charles Brown, David Rocke, Christoph Aeppli, Fernando Galvez, Andrew Whitehead

bioRxiv 2025.02.10.637481; doi: https://doi.org/10.1101/2025.02.10.637481 New Results

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4-Methylpyrazole-mediated inhibition of Cytochrome P450 2E1 protects renal epithelial cells, but not bladder cancer cells, from cisplatin toxicity
Jephte Y. Akakpo, Erika Abbott, Benjamin L. Woolbright, Anup Ramachandran, Rick G. Schnellmann, Darren P. Wallace, John A. Taylor

bioRxiv 2024.11.10.622845; doi: https://doi.org/10.1101/2024.11.10.622845 New Results

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Helix-8 and Carboxyl Terminal Tail Regulation of Proteinase Activated Receptor-4 (PAR4) signalling
Pierre E. Thibeault, Amr A.K. Mousa, Victor M. Mirka, Rithwik Ramachandran

bioRxiv 2025.02.10.637468; doi: https://doi.org/10.1101/2025.02.10.637468 New Results

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An opioid efficacy switch for reversible optical control of peripheral analgesia
Luca Posa, Giovanna Romano, Xiang Ji, Saif Khan, Bruno Matos Paz, Gye Won Han, Antonina L. Nazarova, Saheem A. Zaidi, Mohsen Ranjbar, Kristen Pleil, Vsevolod Katritch, Cornelius Gati, Dirk Trauner, Joshua Levitz

bioRxiv 2024.12.16.628735; doi: https://doi.org/10.1101/2024.12.16.628735 New Results

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CB1 and CB2 receptors differentially modulate the cognitive impact of maternal immune activation and perinatal cannabinoid exposure
Han-Ting Chen, Ken Mackie

bioRxiv 2024.11.16.623455; doi: https://doi.org/10.1101/2024.11.16.623455 New Results

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Combinatorial effects of Zingiber officinale and Citrus limon juices: Hypolipidemic and antioxidant insights from in vivo, in vitro, and in silico investigations
Oussama Bekkouch, Ayoub Bekkouch, Hamza Elbouny, Ilham Touiss, Soufiane El Assri, Mohammed Choukri, Mohammed Bourhia, Kiryang Kim, Sojin Kang, Min Choi, Jinwon Choi, Hyo Jeong Kim, Chi-Hoon Ahn, Moon Nyeo Park, Bonglee Kim, Souliman Amrani

bioRxiv 2025.02.08.637272; doi: https://doi.org/10.1101/2025.02.08.637272 New Results

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Pharmacology and Toxicology

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