Pharmacology and Toxicology

Characterization of the Endogenous DAF-12 Ligand and Its Use as an Anthelmintic Agent in Strongyloides stercoralis
Zhu Wang, Mi Cheong Cheong, Jet Tsien, Heping Deng, Tian Qin, Jonathan D. C. Stoltzfus, Tegegn G. Jaleta, Xinshe Li, James B. Lok, Steven A. Kliewer, David J. Mangelsdorf

bioRxiv 2021.09.07.459359; doi: https://doi.org/10.1101/2021.09.07.459359 New Results

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In silico, In vitro Screening of Plant Extracts for Anti-SARS-CoV-2 Activity and Evaluation of Their Acute and Sub-Acute Toxicity
Latha Damle, Hrishikesh Damle, Shiban Ganju, C Chandrashekar, BR Bharath

bioRxiv 2021.09.07.459230; doi: https://doi.org/10.1101/2021.09.07.459230 Confirmatory Results

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Design principles of collateral sensitivity-based dosing strategies
Linda B. S. Aulin, Apostolos Liakopoulos, Piet H. van der Graaf, Daniel E. Rozen, J. G. Coen van Hasselt

bioRxiv 2021.03.31.437927; doi: https://doi.org/10.1101/2021.03.31.437927 New Results

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GPCR-G protein selectivity – a unified meta-analysis
Alexander S. Hauser, Charlotte Avet, Claire Normand, Arturo Mancini, Asuka Inoue, Michel Bouvier, David E. Gloriam

bioRxiv 2021.09.07.459250; doi: https://doi.org/10.1101/2021.09.07.459250 New Results

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Sapogenin based self-assembly structures activating a non-apoptotic cell death via multiple pathways
Göklem Üner, Erdal Bedir, Onur Serçinoğlu, Petek Ballar Kırmızıbayrak

bioRxiv 2021.09.07.459231; doi: https://doi.org/10.1101/2021.09.07.459231 New Results

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Drug targeting to sites of oxidative stress using the Baeyer-Villiger reaction
Thomas D. Avery, Jiahe Li, Dion J. L. Turner, Fisher R. Cherry, Mohd S. Ur Rasheed, Clarissa Aguilar, Andrew J. Shepherd, Jingxian Yu, Peter M. Grace, Andrew D. Abell

bioRxiv 2021.09.03.458872; doi: https://doi.org/10.1101/2021.09.03.458872 New Results

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Actions of camptothecin derivatives on larvae and adults of the arboviral vector Aedes aegypti
Frederick A. Partridge, Beth C. Poulton, Milly A.I. Lake, Rebecca A. Lees, Harry-Jack Mann, Gareth J. Lycett, David B Sattelle

bioRxiv 2021.09.06.458863; doi: https://doi.org/10.1101/2021.09.06.458863 New Results

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A spatially resolved mechanistic growth law for cancer drug development predicting tumour growing fractions
Adam Nasim, James Yates, Gianne Derks, Carina Dunlop

bioRxiv 2021.05.03.442516; doi: https://doi.org/10.1101/2021.05.03.442516 New Results

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The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology Motivates Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Contagious Variants, and Other Respiratory Viral Infections
David Needham

bioRxiv 2021.08.16.456531; doi: https://doi.org/10.1101/2021.08.16.456531 New Results

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A comparison of Remdesivir versus Au₂₂Glutathione₁₈ in COVID-19 golden hamsters: a better therapeutic outcome of gold compound
Zhesheng He, Fei Ye, Chunyu Zhang, Jiadong Fan, Zhongying Du, Wencong Zhao, Qing Yuan, Wenchao Niu, Fuping Gao, Bo He, Peng Cao, Lina Zhao, Xuejiao Gao, Xingfa Gao, Bo Sun, Yuhui Dong, Jincun Zhao, Jianxun Qi, Huaidong Jiang, Yong Gong, Wenjie Tan, Xueyun Gao

bioRxiv 2020.10.16.342097; doi: https://doi.org/10.1101/2020.10.16.342097 New Results

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Pharmacology and Toxicology

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