Pharmacology and Toxicology

The utility of Saw-scaled viper, Echis pyramidum, and Kenyan sand boa, Eryx colubrinus as bioindicator of heavy metals bioaccumulation in relation to DPTA soil extract and biological consequences.
Doha Magdy Mostafa Sleem, Mohamed Adel Mohamed Kadry, Eman Mahmoud Ezzat Mohallal, Mohamed Assem Marie

bioRxiv 311357; doi: https://doi.org/10.1101/311357 New Results
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm
Frederick A Partridge, Ruth Forman, Nicky J Willis, Carole JR Bataille, Emma A Murphy, Anwen E Brown, Narinder Heyer-Chauhan, Bruno Marinič, Daniel JC Sowood, Graham M Wynne, Kathryn J Else, Angela J Russell, David B Sattelle

bioRxiv 254037; doi: https://doi.org/10.1101/254037 New Results
iPSC-derived neurons as a tool for probing molecular pharmacology of antipsychotic action.
Esther S Kim, E. David Leonardo, Alex Dranovsky

bioRxiv 308486; doi: https://doi.org/10.1101/308486 New Results
Identification and Quantification of Paclitaxel and its Metabolites in Human Meconium from Newborns with Gestational Chemotherapeutic Exposure
Elyce Cardonick, Robert Broadrup, Peining Xu, Mary T. Doan, Helen Jiang, Nathaniel Snyder

bioRxiv 306274; doi: https://doi.org/10.1101/306274 New Results
Azithromycin reduces systemic inflammation and provides survival benefit in murine model of polymicrobial sepsis
Anasuya Patel, Jiji Joseph, Hariharan Periasamy, Santosh Mokale

bioRxiv 303610; doi: https://doi.org/10.1101/303610 Confirmatory Results
Early Exposure to Polycyclic Aromatic Hydrocarbons (PAHs) and Cardiac Toxicity in a Species (Xenopus laevis) with Low Aryl Hydrocarbon Receptor (AHR) Responsiveness
Madison C Sestak, Julia A Pinette, Caithlin M Lamoureux, Susan L Whittemore

bioRxiv 301846; doi: https://doi.org/10.1101/301846 New Results
Targeting redox regulatory site of protein kinase B impedes neutrophilic inflammation
Tsong-Long Hwang, Po-Jen Chen, I-Ling Ko, Chia-Lin Lee, Hao-Chun Hu, Fang-Rong Chang, Yang-Chang Wu, Yann-Lii Leu, Chih-Ching Wu, Yung-Fong Tsai, Cheng-Yu Lin, Chang-Yu Pan

bioRxiv 264184; doi: https://doi.org/10.1101/264184 Confirmatory Results
Structure-based drug design and characterization of sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from Mycobacterium tuberculosis
Jérémie Piton, Anthony Vocat, Andréanne Lupien, Caroline Shi-Yan Foo, Olga Riabova, Vadim Makarov, Stewart T Cole

bioRxiv 298539; doi: https://doi.org/10.1101/298539 New Results
Combination of tenofovir and emtricitabine with efavirenz does not moderate inhibitory effect of efavirenz on mitochondrial function and cholesterol biosynthesis in human T lymphoblastoid cell line
Min Li, Anuoluwapo Sopeyin, Elijah Paintsil

bioRxiv 297044; doi: https://doi.org/10.1101/297044 Confirmatory Results
ADS-J1 Disaggregates Semen-derived Amyloid Fibrils
Jinqing Li, Zichao Yang, Han Liu, Yan Lan, Tingting Zhang, Wenjuan Li, Tao Qi, Yurong Qiu, Lin Li, Xuefeng zhou, Shuwen Liu, Suiyi Tan

bioRxiv 292342; doi: https://doi.org/10.1101/292342 New Results

Pharmacology and Toxicology

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