Pharmacology and Toxicology

A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis
Patrizia Murer, Louis Plüss, Dario Neri

bioRxiv 748962; doi: https://doi.org/10.1101/748962 New Results

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Drug screens of NGLY1 Deficiency worm and fly models reveal catecholamine, NRF2 and anti-inflammatory pathway activation as potential clinical approaches
Sangeetha Iyer, Joshua D. Mast, Hillary Tsang, Tamy P. Rodriguez, Nina DiPrimio, Madeleine Prangley, Feba S. Sam, Zachary Parton, Ethan O. Perlstein

bioRxiv 563478; doi: https://doi.org/10.1101/563478 New Results

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A machine learning and network framework to discover new indications for small molecules
Coryandar Gilvary, Jamal Elkhader, Neel Madhukar, Claire Henchcliffe, Marcus D. Goncalves, Olivier Elemento

bioRxiv 748244; doi: https://doi.org/10.1101/748244 New Results

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The utility of Saw-scaled viper, Echis pyramidum, and Kenyan sand boa, Eryx colubrinus as bioindicator of heavy metals bioaccumulation in relation to DPTA soil extract and biological consequences
Doha M. M. Sleem, Mohamed A. M. Kadry, Eman M. E. Mohallal, Mohamed A. S. Marie

bioRxiv 311357; doi: https://doi.org/10.1101/311357 New Results

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BiasDB: A Comprehensive Database for Biased GPCR Ligands
Christian Omieczynski, Trung Ngoc Nguyen, Dora Sribar, Lihua Deng, Dmitri Stepanov, David Schaller, Gerhard Wolber, Marcel Bermudez

bioRxiv 742643; doi: https://doi.org/10.1101/742643 New Results

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Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr^−/− mice
Huan Tao, Jiansheng Huang, Patricia G. Yancey, Valery Yermalitsky, John L. Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Venkataraman Amarnath, Olivier Boutaud, John A. Oates, L. Jackson Roberts II, Sean S. Davies, MacRae F. Linton

bioRxiv 524884; doi: https://doi.org/10.1101/524884 New Results

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Dysregulation of Sterol Regulatory Element-Binding Protein 2 Gene in HIV Treatment-Experienced Individuals
Anuoluwapo Sopeyin, Lei Zhou, Min Li, Lydia Barakat, Elijah Paintsil

bioRxiv 742486; doi: https://doi.org/10.1101/742486 New Results

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Prescription Opioid Distribution After the Legalization of Recreational Marijuana in Colorado, 2007-2017
Amalie K. Kropp, Stephanie D. Nichols, Daniel Y. Chung, Kenneth L. McCall, Brian J. Piper

bioRxiv 702811; doi: https://doi.org/10.1101/702811 New Results

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Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance
Grant C. Churchill, Michael Strupp, Antony Galione, Frances M. Platt

bioRxiv 738286; doi: https://doi.org/10.1101/738286 New Results

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Crystal structure of the M₅ muscarinic acetylcholine receptor
Ziva Vuckovic, Patrick R. Gentry, Alice E. Berizzi, Kunio Hirata, Swapna Varghese, Geoff Thompson, Emma T. van der Westhuizen, Wessel A.C. Burger, Raphaёl Rahmani, Celine Valant, Christopher J. Langmead, Craig W. Lindsley, Jonathan Baell, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos, David M. Thal

bioRxiv 730622; doi: https://doi.org/10.1101/730622 New Results

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Pharmacology and Toxicology

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