Pharmacology and Toxicology

The sensitivity of transcriptomics BMD modeling to the methods used for microarray data normalization
Roman Mezencev, Scott Auerbach

bioRxiv 781567; doi: https://doi.org/10.1101/781567 New Results

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Applications of the Microphysiology Systems Database for Experimental ADME-Tox and Disease Models
Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert Gough

bioRxiv 776500; doi: https://doi.org/10.1101/776500 New Results

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RNA interference of NADPH-Cytochrome P450 reductase increases susceptibilities to multiple acaricides in Tetranychus urticae
Adekunle W. Adesanya, Antonio Cardenas, Mark D. Lavine, Doug B. Walsh, Laura C. Lavine, Fang Zhu

bioRxiv 780536; doi: https://doi.org/10.1101/780536 New Results

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High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches
Julien Slagboom, Marija Mladić, Chunfang Xie, Freek Vonk, Govert W. Somsen, Nicholas R. Casewell, Jeroen Kool

bioRxiv 780155; doi: https://doi.org/10.1101/780155 New Results

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Δ⁹-Tetrahydrocannabinol (THC) impairs visual working memory performance
Kirsten C. S. Adam, Manoj K. Doss, Elisa Pabon, Edward K. Vogel, Harriet de Wit

bioRxiv 778068; doi: https://doi.org/10.1101/778068 New Results

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Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells
Huan Huan Tan, Noel F. Thomas, Salmaan H. Inayat-Hussain, Kok Meng Chan

bioRxiv 777193; doi: https://doi.org/10.1101/777193 New Results

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Direct detection of circulating microRNA-122 using dynamic chemical labelling with single molecule detection overcomes stability and isomiR challenges for biomarker qualification
Barbara López-Longarela, Emma E. Morrison, John D. Tranter, Lianne Chahman-Vos, Jean-François Léonard, Jean-Charles Gautier, Sébastien Laurent, Aude Lartigau, Eric Boitier, Lucile Sautier, Pedro Carmona-Saez, Jordi Martorell-Marugan, Richard J. Mellanby, Salvatore Pernagallo, Hugh Ilyine, David M. Rissin, David C. Duffy, James W. Dear, Juan J. Díaz-Mochón

bioRxiv 777458; doi: https://doi.org/10.1101/777458 New Results

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Aceclofenac Fast Dispersible Tablet Formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics
Riffat Yasmin, Muhammad Harris Shoaib, Farrukh Rafiq Ahmed, Faaiza Qazi, Huma Ali, Farya Zafar

bioRxiv 773671; doi: https://doi.org/10.1101/773671 New Results

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A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques
Jonathan T. Su, Solange M Simpson, Samuel Sung, Ewa Bryndza Tfaily, Ronald Veazey, Mark Marzinke, Jiang Qiu, David Watrous, Lakmini Widanapathirana, Elizabeth Pearson, M. Melissa Peet, Dipu Karunakaran, Brooke Grasperge, Georgina Dobek, Charlette M. Cain, Thomas Hope, Patrick F. Kiser

bioRxiv 775452; doi: https://doi.org/10.1101/775452 New Results

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Machine learning-assisted neurotoxicity prediction in human midbrain organoids
Anna S. Monzel, Kathrin Hemmer, Tony Kaoma Mukendi, Philippe Lucarelli, Isabel Rosety, Alise Zagare, Silvia Bolognin, Paul Antony, Sarah L. Nickels, Rejko Krueger, Francisco Azuaje, Jens C. Schwamborn

bioRxiv 774240; doi: https://doi.org/10.1101/774240 New Results

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Pharmacology and Toxicology

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