Pharmacology and Toxicology

Pore-modulating toxins exploit inherent slow inactivation to block K⁺ channels
Izhar Karbat, Hagit Altman-Gueta, Shachar Fine, Tibor Szanto, Shelly Hamer-Rogotner, Orly Dym, Felix Frolow, Dalia Gordon, Gyorgy Panyi, Michael Gurevitz, Eitan Reuveny

bioRxiv 576132; doi: https://doi.org/10.1101/576132 New Results
Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming
Huan Wang, Robert P. Sheehan, Adam C. Palmer, Robert A. Everley, Sarah A. Boswell, Noga Ron-Harel, Alison E. Ringel, Kristina M. Holton, Connor A. Jacobson, Alison R. Erickson, Laura Maliszewski, Marcia C. Haigis, Peter K. Sorger

bioRxiv 365841; doi: https://doi.org/10.1101/365841 New Results
Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949
Simon Lind, Martina Sundqvist, Rikard Holmdahl, Claes Dahlgren, Huamei Forsman, Peter Olofsson

bioRxiv 571604; doi: https://doi.org/10.1101/571604 New Results
Structure-Unbinding Kinetics Relationship of p38α MAPK Inhibitors
Xiaoxia Ge, Hepan Tan, Lei Xie

bioRxiv 510255; doi: https://doi.org/10.1101/510255 New Results
Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines
Christopher R. M. Asquith, Neil Fleck, Christoph Grundner, William J. Zuercher

bioRxiv 570002; doi: https://doi.org/10.1101/570002 New Results
Saxitoxin and tetrodotoxin bioavailability increases in future oceans
C.C. Roggatz, N. Fletcher, D.M. Benoit, A.C. Algar, A. Doroff, B. Wright, K.C. Wollenberg Valero, J.D. Hardege

bioRxiv 562694; doi: https://doi.org/10.1101/562694 New Results
Urinary biomarker and histopathological evaluation of vancomycin and piperacillin-tazobactam nephrotoxicity in comparison with vancomycin in a rat model and a confirmatory cellular model
Gwendolyn M. Pais, Jiajun Liu, Sean N. Avedissian, Theodoros Xanthos, Athanasios Chalkias, Ernesto d’Aloja, Emanuela Locci, Annette Gilchrist, Walter C. Prozialeck, Nathaniel J. Rhodes, Thomas P. Lodise, Julie C. Fitzgerald, Kevin Downes, Athena F. Zuppa, Marc H. Scheetz

bioRxiv 568907; doi: https://doi.org/10.1101/568907 New Results
Absence of entourage: Terpenoids commonly found in Cannabis sativa do not modulate the functional activity of Δ9-THC at human CB1and CB2 receptors
Marina Santiago, Shivani Sachdev, Jonathon C Arnold, Iain S McGregor, Mark Connor

bioRxiv 569079; doi: https://doi.org/10.1101/569079 New Results
Application of Global Metabolomics to the Identification of Complex Counterfeit Medicinal Products
Conor Jenkins, Ben Orsburn

bioRxiv 567339; doi: https://doi.org/10.1101/567339 New Results
Synthesis, SAR and Docking Studies of Substituted Aryl phenylthiazolyl phenylcarboxamide as potential PTP1B Inhibitors
Kanika Varshney, Amit K. Gupta, Arun Rawat, Rohit Srivastava, Akansha Mishra, Mridula Saxena, Arvind K. Srivastava, Sudha Jain, Anil K. Saxena

bioRxiv 472670; doi: https://doi.org/10.1101/472670 New Results

Pharmacology and Toxicology

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