Pharmacology and Toxicology

ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease
Xiaowen Wu, Guanxing Pan, Lin Chang, Yulong Zhang, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi, Jianjun Zhang, Ruyi Xue, She Chen, Hu Hu, Jianzeng Dong, Si Zhang, Zhongren Ding

bioRxiv 2024.08.20.608887; doi: https://doi.org/10.1101/2024.08.20.608887

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Optimising experimental designs for model selection of ion channel drug binding mechanisms
Frankie Patten-Elliott, Chon Lok Lei, Simon P. Preston, Richard D. Wilkinson, Gary R. Mirams

bioRxiv 2024.08.20.608856; doi: https://doi.org/10.1101/2024.08.20.608856

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Enabling Transparent Toxicokinetic Modeling for Public Health Risk Assessment
Sarah E. Davidson-Fritz, Caroline L. Ring, Marina V. Evans, Celia M. Schacht, Xiaoqing Chang, Miyuki Breen, Gregory S. Honda, Elaina Kenyon, Matthew W. Linakis, Annabel Meade, Robert G. Pearce, Mark A. Sfeir, James P. Sluka, Michael J. Devito, John F. Wambaugh

bioRxiv 2024.08.19.608571; doi: https://doi.org/10.1101/2024.08.19.608571

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Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoid in lipopolysaccharide-treated HEI-OC1 cells through modulation of Foxp3/Nrf2 signaling pathway
Jie Li, Xiaoyan Zhu, Shiming Ye, Qi Dong, Jie Hou, Jing Liu, Wandong She

bioRxiv 2024.08.19.608552; doi: https://doi.org/10.1101/2024.08.19.608552

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4-week GLP immunotoxicity assessment of lactoferrin alpha produced by Komagataella phaffii in Sprague Dawley rats
Ross Peterson, Robert B. Crawford, Lance K. Blevins, Norbert E. Kaminski, Anthony J. Clark, Carrie-Anne Malinczak

bioRxiv 2024.08.16.608335; doi: https://doi.org/10.1101/2024.08.16.608335

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Xylazine Exacerbates Fentanyl-Induced Respiratory Depression and Bradycardia
Catherine Demery-Poulos, Sierra C. Moore, Erica S. Levitt, Jessica P. Anand, John R. Traynor

bioRxiv 2024.08.16.608310; doi: https://doi.org/10.1101/2024.08.16.608310

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The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21
Suowen Xu, Zhenghong Liu, Tian Tian, Wenqi Zhao, Zhihua Wang, Monan Liu, Mengyun Xu, Fanshun Zhang, Zhidan Zhang, Meijie Chen, Yanjun Yin, Meiming Su, Wenhao Pan, Shiyong Liu, Min-dian Li, Peter J. Little, Danielle Kamato, Songyang Zhang, Dongdong Wang, Stefan Offermanns, John R. Speakman, Jianping Weng

bioRxiv 2024.08.18.608423; doi: https://doi.org/10.1101/2024.08.18.608423

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Sulfoglycodendron Antivirals with Scalable Architectures and Activities
Francesco Coppola, Roya Jafari, Katherine D. McReynolds, Petr Kŕal

bioRxiv 2024.08.01.606251; doi: https://doi.org/10.1101/2024.08.01.606251

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Endoplasmic reticulum stress inhibition preserves mitochondrial function and cell survival during early onset of isoniazid-induced oxidative stress
Truong Thi My Nhung, Nguyen Ky Phat, Trinh Tam Anh, Tran Diem Nghi, Nguyen Quang Thu, Ara Lee, Nguyen Tran Nam Tien, Nguyen Ky Anh, Kimoon Kim, Duc Ninh Nguyen, Dong-Hyun Kim, Sang Ki Park, Nguyen Phuoc Long

bioRxiv 2024.08.12.607527; doi: https://doi.org/10.1101/2024.08.12.607527

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A Novel Computational Machine Learning Pipeline to Quantify Similarities in Three-Dimensional Protein Structures
Shreyas U. Hirway, Xiao Xu, Fan Fan

bioRxiv 2024.08.14.607969; doi: https://doi.org/10.1101/2024.08.14.607969

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Pharmacology and Toxicology

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