Systems Biology

Active and machine learning-based approaches to rapidly enhance microbial chemical production
Prashant Kumar, Paul A. Adamczyk, Xiaolin Zhang, Ramon Bonela Andrade, Philip A. Romero, Parameswaran Ramanathan, Jennifer L. Reed

bioRxiv 2020.12.01.406439; doi: https://doi.org/10.1101/2020.12.01.406439

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Prediction of Michaelis constants from structural features using deep learning
Alexander Kroll, David Heckmann, Martin J. Lercher

bioRxiv 2020.12.01.405928; doi: https://doi.org/10.1101/2020.12.01.405928

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Methods for analysing lineage tracing datasets
Vasiliki Kostiou, Huairen Zhang, Michael WJ Hall, Philip H Jones, Benjamin A Hall

bioRxiv 2020.01.11.901819; doi: https://doi.org/10.1101/2020.01.11.901819

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Multimodal Single-Cell Omics Analysis of COVID-19 Sex Differences in Human Immune Systems
Yuan Hou, Yadi Zhou, Michaela U. Gack, Justin D. Lathia, Asha Kallianpur, Reena Mehra, Timothy Chan, Jae U. Jung, Lara Jehi, Charis Eng, Feixiong Cheng

bioRxiv 2020.12.01.407007; doi: https://doi.org/10.1101/2020.12.01.407007

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A genome-scale metabolic network model and machine learning predict amino acid concentrations in Chinese Hamster Ovary cell cultures
Song-Min Schinn, Carly Morrison, Wei Wei, Lin Zhang, Nathan E. Lewis

bioRxiv 2020.09.02.279687; doi: https://doi.org/10.1101/2020.09.02.279687

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On testing structural identifiability by a simple scaling method: relying on scaling symmetries can be misleading
Alejandro F. Villaverde, Gemma Massonis Feixas

bioRxiv 2020.11.30.403956; doi: https://doi.org/10.1101/2020.11.30.403956 Contradictory Results

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A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement
Samuel A. Ramirez, Michael Pablo, Sean Burk, Daniel J. Lew, Timothy C. Elston

bioRxiv 2020.11.30.404657; doi: https://doi.org/10.1101/2020.11.30.404657

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Unified AI framework to uncover deep interrelationships between gene expression and Alzheimer’s disease neuropathologies
Nicasia Beebe-Wang, Safiye Celik, Ethan Weinberger, Pascal Sturmfels, Philip L. De Jager, Sara Mostafavi, Su-In Lee

bioRxiv 2020.11.30.404087; doi: https://doi.org/10.1101/2020.11.30.404087

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Dynamic modelling of the PI3K/mTOR signalling network uncovers biphasic dependence of mTORC1 activation on the mTORC2 subunit Sin1
Milad Ghomlaghi, Sungyoung Shin, Guang Yang, David E. James, Lan K. Nguyen

bioRxiv 2020.11.30.403774; doi: https://doi.org/10.1101/2020.11.30.403774

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Modeling the circadian regulation of the immune system: sexually dimorphic effects of shift work
Stéphanie M.C. Abo, Anita T. Layton

bioRxiv 2020.11.30.403733; doi: https://doi.org/10.1101/2020.11.30.403733

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Systems Biology

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