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Extensive Phenotypic Changes Associated with Large-scale Horizontal Gene Transfer

Kevin Dougherty, Brian A. Smith, Autumn F. Moore, Shannon Maitland, Chris Fanger, Rachel Murillo, View ORCID ProfileDavid A. Baltrus
doi: https://doi.org/10.1101/001362
Kevin Dougherty
1School of Plant Sciences, University of Arizona, Tucson AZ, 85721-0036
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Brian A. Smith
1School of Plant Sciences, University of Arizona, Tucson AZ, 85721-0036
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Autumn F. Moore
1School of Plant Sciences, University of Arizona, Tucson AZ, 85721-0036
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Shannon Maitland
1School of Plant Sciences, University of Arizona, Tucson AZ, 85721-0036
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Chris Fanger
1School of Plant Sciences, University of Arizona, Tucson AZ, 85721-0036
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Rachel Murillo
1School of Plant Sciences, University of Arizona, Tucson AZ, 85721-0036
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David A. Baltrus
1School of Plant Sciences, University of Arizona, Tucson AZ, 85721-0036
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  • ORCID record for David A. Baltrus
  • For correspondence: Baltrus@email.arizona.edu
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ABSTRACT

Horizontal gene transfer often leads to phenotypic changes within recipient organisms independent of any immediate evolutionary benefits. While secondary phenotypic effects of horizontal transfer (i.e. changes in growth rates) have been demonstrated and studied across a variety of systems using relatively small plasmid and phage, little is known about how size of the acquired region affects the magnitude or number of such costs. Here we describe an amazing breadth of phenotypic changes which occur after a large-scale horizontal transfer event (~1Mb megaplasmid) within Pseudomonas stutzeri including sensitization to various stresses as well as changes in bacterial behavior. These results highlight the power of horizontal transfer to shift pleiotropic relationships and cellular networks within bacterial genomes. They also provide an important context for how secondary effects of transfer can bias evolutionary trajectories and interactions between species. Lastly, these results and system provide a foundation to investigate evolutionary consequences in real time as newly acquired regions are ameliorated and integrated into new genomic contexts.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND Unported 3.0 license.
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Posted December 12, 2013.
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Extensive Phenotypic Changes Associated with Large-scale Horizontal Gene Transfer
Kevin Dougherty, Brian A. Smith, Autumn F. Moore, Shannon Maitland, Chris Fanger, Rachel Murillo, David A. Baltrus
bioRxiv 001362; doi: https://doi.org/10.1101/001362
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Extensive Phenotypic Changes Associated with Large-scale Horizontal Gene Transfer
Kevin Dougherty, Brian A. Smith, Autumn F. Moore, Shannon Maitland, Chris Fanger, Rachel Murillo, David A. Baltrus
bioRxiv 001362; doi: https://doi.org/10.1101/001362

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