Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Epigenetic Modifications are Associated with Inter-species Gene Expression Variation in Primates

Xiang Zhou, Carolyn E. Cain, Marsha Myrthil, Noah Lewellen, Katelyn Michelini, Emily R. Davenport, Matthew Stephens, Jonathan K. Pritchard, Yoav Gilad
doi: https://doi.org/10.1101/003467
Xiang Zhou
1Department of Human Genetics, University of Chicago, Chicago, IL
2Department of Statistics, University of Chicago, Chicago, IL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carolyn E. Cain
1Department of Human Genetics, University of Chicago, Chicago, IL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marsha Myrthil
1Department of Human Genetics, University of Chicago, Chicago, IL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Noah Lewellen
1Department of Human Genetics, University of Chicago, Chicago, IL
3Howard Hughes Medical Institute, Chevy Chase, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katelyn Michelini
1Department of Human Genetics, University of Chicago, Chicago, IL
3Howard Hughes Medical Institute, Chevy Chase, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emily R. Davenport
1Department of Human Genetics, University of Chicago, Chicago, IL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew Stephens
1Department of Human Genetics, University of Chicago, Chicago, IL
2Department of Statistics, University of Chicago, Chicago, IL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan K. Pritchard
1Department of Human Genetics, University of Chicago, Chicago, IL
3Howard Hughes Medical Institute, Chevy Chase, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pritch@uchicago.edu gilad@uchicago.edu
Yoav Gilad
1Department of Human Genetics, University of Chicago, Chicago, IL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pritch@uchicago.edu gilad@uchicago.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Changes in gene regulation level have long been thought to play an important role in evolution and speciation, especially in primates. Over the past decade, comparative genomic studies have revealed extensive inter-species differences in gene expression levels yet we know much less about the extent to which regulatory mechanisms differ between species. To begin addressing this gap, we performed a comparative epigenetic study in primate lymphoblastoid cell lines (LCLs), to query the contribution of RNA polymerase II (Pol II) and four histone modifications (H3K4me1, H3K4me3, H3K27ac, and H3K27me3) to inter-species variation in gene expression levels. We found that inter-species differences in mark enrichment near transcription start sites are significantly more often associated with inter-species differences in the corresponding gene expression level than expected by chance alone. Interestingly, we also found that first-order interactions among the histone marks and Pol II do not markedly contribute to the degree of association between the marks and inter-species variation in gene expression levels, suggesting that the marginal effects of the five marks dominate this contribution.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted March 19, 2014.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Epigenetic Modifications are Associated with Inter-species Gene Expression Variation in Primates
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Epigenetic Modifications are Associated with Inter-species Gene Expression Variation in Primates
Xiang Zhou, Carolyn E. Cain, Marsha Myrthil, Noah Lewellen, Katelyn Michelini, Emily R. Davenport, Matthew Stephens, Jonathan K. Pritchard, Yoav Gilad
bioRxiv 003467; doi: https://doi.org/10.1101/003467
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Epigenetic Modifications are Associated with Inter-species Gene Expression Variation in Primates
Xiang Zhou, Carolyn E. Cain, Marsha Myrthil, Noah Lewellen, Katelyn Michelini, Emily R. Davenport, Matthew Stephens, Jonathan K. Pritchard, Yoav Gilad
bioRxiv 003467; doi: https://doi.org/10.1101/003467

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genomics
Subject Areas
All Articles
  • Animal Behavior and Cognition (3505)
  • Biochemistry (7348)
  • Bioengineering (5324)
  • Bioinformatics (20266)
  • Biophysics (10019)
  • Cancer Biology (7744)
  • Cell Biology (11305)
  • Clinical Trials (138)
  • Developmental Biology (6437)
  • Ecology (9953)
  • Epidemiology (2065)
  • Evolutionary Biology (13325)
  • Genetics (9361)
  • Genomics (12586)
  • Immunology (7702)
  • Microbiology (19024)
  • Molecular Biology (7443)
  • Neuroscience (41041)
  • Paleontology (300)
  • Pathology (1229)
  • Pharmacology and Toxicology (2138)
  • Physiology (3161)
  • Plant Biology (6861)
  • Scientific Communication and Education (1273)
  • Synthetic Biology (1896)
  • Systems Biology (5313)
  • Zoology (1089)