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Regulatory variants explain much more heritability than coding variants across 11 common diseases
Alexander Gusev, S. Hong Lee, Benjamin M. Neale, Gosia Trynka, Bjarni J. Vilhjálmsson, Hilary Finucane, Han Xu, Chongzhi Zang, Stephan Ripke, Eli Stahl, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Anna K. Kähler, Christina M. Hultman, Shaun M. Purcell, Steven A. McCarroll, Mark Daly, Bogdan Pasaniuc, Patrick F. Sullivan, Naomi R. Wray, Soumya Raychaudhuri, Alkes L. Price
doi: https://doi.org/10.1101/004309
Alexander Gusev
1Harvard School of Public Health, Boston, Massachusetts, USA.
S. Hong Lee
2The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia.
Benjamin M. Neale
3Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Gosia Trynka
5Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
6Division of Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
7Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
8Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Bjarni J. Vilhjálmsson
1Harvard School of Public Health, Boston, Massachusetts, USA.
Hilary Finucane
9Department of Mathematics, Massachusetts Institute of Technology, Massachusetts, USA.
Han Xu
10Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, USA.
Chongzhi Zang
10Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, USA.
Stephan Ripke
3Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Eli Stahl
11The Department of Psychiatry at Mount Sinai School of Medicine, New York, New York, USA.
Anna K. Kähler
12Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Christina M. Hultman
12Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Shaun M. Purcell
3Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
11The Department of Psychiatry at Mount Sinai School of Medicine, New York, New York, USA.
Steven A. McCarroll
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Mark Daly
3Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Bogdan Pasaniuc
13Department of Pathology and Laboratory Medicine, Geffen School of Medicine at UCLA, Los Angeles, California, USA
Patrick F. Sullivan
14Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Naomi R. Wray
2The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia.
Soumya Raychaudhuri
5Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
6Division of Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
7Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
8Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
15Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
Alkes L. Price
1Harvard School of Public Health, Boston, Massachusetts, USA.
8Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
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Posted April 21, 2014.
Regulatory variants explain much more heritability than coding variants across 11 common diseases
Alexander Gusev, S. Hong Lee, Benjamin M. Neale, Gosia Trynka, Bjarni J. Vilhjálmsson, Hilary Finucane, Han Xu, Chongzhi Zang, Stephan Ripke, Eli Stahl, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Anna K. Kähler, Christina M. Hultman, Shaun M. Purcell, Steven A. McCarroll, Mark Daly, Bogdan Pasaniuc, Patrick F. Sullivan, Naomi R. Wray, Soumya Raychaudhuri, Alkes L. Price
bioRxiv 004309; doi: https://doi.org/10.1101/004309
Regulatory variants explain much more heritability than coding variants across 11 common diseases
Alexander Gusev, S. Hong Lee, Benjamin M. Neale, Gosia Trynka, Bjarni J. Vilhjálmsson, Hilary Finucane, Han Xu, Chongzhi Zang, Stephan Ripke, Eli Stahl, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Anna K. Kähler, Christina M. Hultman, Shaun M. Purcell, Steven A. McCarroll, Mark Daly, Bogdan Pasaniuc, Patrick F. Sullivan, Naomi R. Wray, Soumya Raychaudhuri, Alkes L. Price
bioRxiv 004309; doi: https://doi.org/10.1101/004309
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