Abstract
Biallelic somatic mutations in the RNase IIIb domain of DICER1 are recurrent in different cancer types, disrupting the processing of the 5p, but not 3p, strand of the pre-miRNAs. Using data from the Cancer Genome Atlas project, we showed these mutations cause 5p-strand miRNA depletion, which in turn causes up-regulation of targets of particular miRNA families in human tumors. Furthermore, we identified a previously unknown re-current mutation in the RNase IIIa domain that also disrupts 5p-strand processing.
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